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Q4WMS9

- MANBA_ASPFU

UniProt

Q4WMS9 - MANBA_ASPFU

Protein

Beta-mannosidase A

Gene

mndA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei474 – 4741Proton donorBy similarity

    GO - Molecular functioni

    1. beta-mannosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00280.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-mannosidase A (EC:3.2.1.25)
    Alternative name(s):
    Mannanase A
    Short name:
    Mannase A
    Gene namesi
    Name:mndA
    ORF Names:AFUA_6G08840
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 6

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 926905Beta-mannosidase APRO_0000394646Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi532 – 5321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi603 – 6031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi626 – 6261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi653 – 6531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi733 – 7331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi756 – 7561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi785 – 7851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi793 – 7931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi905 – 9051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00001844.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4WMS9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000216059.
    KOiK01192.
    OMAiCHATQLF.
    OrthoDBiEOG78D7TH.

    Family and domain databases

    Gene3Di2.60.120.260. 2 hits.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4WMS9-1 [UniParc]FASTAAdd to Basket

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    MHVKAETVLA LLTPAPPSVV GQHVVDLSGD GWTLSSTALN RTVPGHLPSQ    50
    VHLDLFEAGV IDIMASMILT FVGLRMPIGR IPATRLKAYF ESTWLVFDGL 100
    DTFATITFCD QHVGSTDNQF RQHHFDVSQI LKECKQDPVL RINFGSAPNI 150
    ANTIAKSPDA EEWPPGVQIT NEYPNRWYIR KEQSDFGWDW GPAFAPVGPW 200
    KPSYIVQNGH AELYVLNTDI DIYRQGQINY LPPDQSQPWI VNASIDFLGP 250
    VPCKPSMSIE IKDAATGSVL SSGLLQNVTV SGKSITGTTT IDGDAPKLWW 300
    PSGMGKQNLY NVTITVQNDM KKSLAKVTKR TGFRTIFLNQ RNITDDQLAQ 350
    GIAPGANWHF EINGYEFYTK GSNIIPPDAF WPRVTQARMA RLFDAVTAGN 400
    QNMLRVWASG AYLHDFIYDL ADEKGILLWS EFQFSDALYP VNDAFLENVA 450
    AEVVYNVRRV NHHPSLALWA GGNEIESLML PMARRADPTG YSKYIGEYEK 500
    LYISLILPLV YENTRSITYS PSSTTEGYLY VNLSAPVPMA ERYSNTTPGS 550
    YYGDTDYYNY DTSVSFDYNH YPVGRFANEF GFHSMPSLQT WQQAVDPEDL 600
    QFNSSVVVLR NHHYTAGGLF TDNFKNSSKG MGEMTMGVEA YYPIPSKSDS 650
    VANFSAWCHA TQLFQADLYK SQIQFYRRGS GMPERQLGSL YWQLEDIWQA 700
    PTWAGIEYDG RWKVLHYVAR DIYQPIIVSP FWNYTTGRLE VYVTSDLWEP 750
    AQGTVNLTWV DLSGKSIANN AGTPETVSFT VGALNTTNIY TTNISELSLP 800
    DLKDSILILS LSGEGRLPNA SSKKAFVHQN HFTPVFPKDL SLKDPKLEVS 850
    YSPESRKFTV QATGGVSLYT WLDYPAGAVG YFEANAFVLL PGVPKEVSFV 900
    AQEGNVTDDW LQRVTVQSLW DQKVRD 926
    Length:926
    Mass (Da):103,736
    Last modified:July 5, 2005 - v1
    Checksum:i77968D62D87000E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000006 Genomic DNA. Translation: EAL88735.1.
    RefSeqiXP_750773.1. XM_745680.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00001844; CADAFUAP00001844; CADAFUAG00001844.
    GeneIDi3508060.
    KEGGiafm:AFUA_6G08840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000006 Genomic DNA. Translation: EAL88735.1 .
    RefSeqi XP_750773.1. XM_745680.1.

    3D structure databases

    ProteinModelPortali Q4WMS9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00001844.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00001844 ; CADAFUAP00001844 ; CADAFUAG00001844 .
    GeneIDi 3508060.
    KEGGi afm:AFUA_6G08840.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000216059.
    KOi K01192.
    OMAi CHATQLF.
    OrthoDBi EOG78D7TH.

    Enzyme and pathway databases

    UniPathwayi UPA00280 .

    Family and domain databases

    Gene3Di 2.60.120.260. 2 hits.
    2.60.40.320. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR008979. Galactose-bd-like.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiMANBA_ASPFU
    AccessioniPrimary (citable) accession number: Q4WMS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3