SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4WMP0

- EXGD_ASPFU

UniProt

Q4WMP0 - EXGD_ASPFU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable glucan 1,3-beta-glucosidase D
Gene
exgD, AFUA_6G09250
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan By similarity.

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei599 – 5991Proton donor By similarity
Active sitei704 – 7041Nucleophile By similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase D (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase D
Gene namesi
Name:exgD
ORF Names:AFUA_6G09250
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 305305Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei306 – 32621Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini327 – 833507Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Probable glucan 1,3-beta-glucosidase D
PRO_0000395164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi332 – 3321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi378 – 3781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi383 – 3831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi548 – 5481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi560 – 5601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi638 – 6381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi671 – 6711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi691 – 6911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00002365.

Structurei

3D structure databases

ProteinModelPortaliQ4WMP0.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 176171Arg-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2730.
HOGENOMiHOG000114462.
KOiK01210.
OMAiNIITHYG.
OrthoDBiEOG7ZPNTV.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4WMP0-1 [UniParc]FASTAAdd to Basket

« Hide

MPTHSRSRDR YGGRDSDREA RYDYDYARRR YATDDDDDYD DDELEHDLTE    50
RRYRRDGYRP PRESRARGYY ERDAEGAADE ELLGNERDPG PRASRSYGDD 100
YDARRREHSR AREAPRRSER HRDRDREGRS RRRAYEDDGR HRTRDGRRDR 150
GRESDGEARR SRRREAGRET AARKHRSSDS TNSASHLLSA DALAKLGAQY 200
EKEERRKREI AKDAAKAERK RQKKLAVVGE ETRALRDPPG ESHRDRTKAR 250
VASGAYLEEG RSPEMRVRHR GGGGPAMEAR WRKEGSWGGT MDDSGGGRPF 300
WKRKRWIGLG ALIIILVIVI PVAVVVSKKH DNKSDPADSQ GTSPGKSNLD 350
GLSHDSIPAY AQGTYLDPWT WYDTTDFNVT FTNETVGGLS IMGLNSTWDD 400
SARPNDNVPP LNEPFPYGSQ PIRGVNLGGW LSIEPFIVPS LFDSYSSVSG 450
IIDEWTLSKR LGSSAASTLE KHYATFITEQ DFADIRDAGL DHVRIQYSYW 500
AVATYDDDPY VAKISWRYLL RAIEYCRKYG LRVNLDPHGI PGSQNGWNHS 550
GREGVIGWLN GTDGELNRNR SLAVHDSVSK FFAQDRYKNI VTIYGLVNEP 600
LMLSLSIEDV LDWTTEATKL VQKNGITAYV ALHDGFLNLS KWKSMLKNRP 650
DKMLLDTHQY TIFNTGQIGL NHTAKVNLIC NDWYNMIKEI NSTSTGWGPT 700
ICGEWSQADT DCAKYLNNVG RGTRWEGTFS LTDSTQYCPT ADTGPPCSCA 750
NANADVSKYS ADYKKFLQTY AEAQMSAFET GQGWFYWTWR TESAAQWSYR 800
TAWKNGFMPA KAYAPSFRCG DAVPDFGDLP EYY 833
Length:833
Mass (Da):94,775
Last modified:July 5, 2005 - v1
Checksum:i6A08231B6A8A1855
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000006 Genomic DNA. Translation: EAL88774.1.
RefSeqiXP_750812.1. XM_745719.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00002365; CADAFUAP00002365; CADAFUAG00002365.
GeneIDi3508103.
KEGGiafm:AFUA_6G09250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000006 Genomic DNA. Translation: EAL88774.1 .
RefSeqi XP_750812.1. XM_745719.1.

3D structure databases

ProteinModelPortali Q4WMP0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00002365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00002365 ; CADAFUAP00002365 ; CADAFUAG00002365 .
GeneIDi 3508103.
KEGGi afm:AFUA_6G09250.

Phylogenomic databases

eggNOGi COG2730.
HOGENOMi HOG000114462.
KOi K01210.
OMAi NIITHYG.
OrthoDBi EOG7ZPNTV.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiEXGD_ASPFU
AccessioniPrimary (citable) accession number: Q4WMP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi