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Q4WLY1

- BGLJ_ASPFU

UniProt

Q4WLY1 - BGLJ_ASPFU

Protein

Probable beta-glucosidase J

Gene

bglJ

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei233 – 2331By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-glucosidase J (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase J
    Cellobiase J
    Gentiobiase J
    Gene namesi
    Name:bglJ
    ORF Names:AFUA_6G11910
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 6

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 865865Probable beta-glucosidase JPRO_0000394893Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi447 – 4471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi764 – 7641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00001941.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4WLY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini415 – 548134PA14Add
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated
    Contains 1 PA14 domain.Curated

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    KOiK05349.
    OrthoDBiEOG7H799Q.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 2 hits.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    IPR011658. PA14.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    PF07691. PA14. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SMARTiSM00758. PA14. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q4WLY1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSIDTVGMG QRAIDQIISE LSLNEKVALL SGVDAWHTFA IPRLGIPSIR    50
    TTDGPNGARG TRYFNGVPSA CLPCGTALGA TFDRDLIFSL GQLLAAECRA 100
    KGAHVLLGPT INIQRGPLGG RGFESFSEDP VLSGLAAASY CSGVQDGGVV 150
    PTLKHLVCND QEHERVAVSA LVTPRALREI YLLPFQLAIQ GARPGAVMTS 200
    YNKVNGLHAS ENPGLIRDIL RGEWGYEGAV ISDWFGTYSV ADAVNAGLDL 250
    EMPGPTRFRG PALMHALTSN KVSEKTLNER VRKVLELVQL ASRAGVPEYA 300
    PERKLNRPED RALLRRAAGE SVVLLKNDKN DSTNSPILPL DREKTTLVIG 350
    PNADLAAYCG GGSASLLAYY TVTPRQGIAD KCGAEQVVFS QGCYGHKELP 400
    LLGEHLRTIE TGQPGYTFRV YTEPPPASGS FKGSDSRTPV DELHMTNSSA 450
    FLMDYSHPQI SGDTYYATLE GTFEPPESGV YEFGLTVAGT GLLYIDGVLV 500
    VDNKTVQRAG TSFFGIGTVE ERGERYLEAG KKHHVFVEFG TAPTSNLQHH 550
    HGVVSFGPGG LRLGGCRKLD TDTAIQQAVQ SAAQADQVVV CVGLSGDWES 600
    EGFDRPHMDL PPGTDELVNA VLAVQPNAVI VVQSGTPVTM PWADKAKALL 650
    QAWYGGNEAG NGIADVLFGD VNPSAKLPLT FPRELAQNPS YLSYRSERGR 700
    VLYSEDIYVG YRYYDTTGQP PLFRFGHGLS YSTFHLRDLT VRETAPYAAN 750
    IKESSLRVSV TVSNTSARPG AEVVLVYVRP PAAACSVGRP VRELKGYEKV 800
    MLQPGETREV SITIPLGLAT SFWDEGCDAW LSEKGLYFVE AVGTGEGNTL 850
    VAPLTVQVSR VWNGL 865
    Length:865
    Mass (Da):92,992
    Last modified:June 15, 2010 - v2
    Checksum:i3D9E8E3E09B04762
    GO

    Sequence cautioni

    The sequence EAL89033.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000006 Genomic DNA. Translation: EAL89033.1. Sequence problems.
    RefSeqiXP_751071.1. XM_745978.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00001941; CADAFUAP00001941; CADAFUAG00001941.
    GeneIDi3508376.
    KEGGiafm:AFUA_6G11910.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000006 Genomic DNA. Translation: EAL89033.1 . Sequence problems.
    RefSeqi XP_751071.1. XM_745978.1.

    3D structure databases

    ProteinModelPortali Q4WLY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00001941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00001941 ; CADAFUAP00001941 ; CADAFUAG00001941 .
    GeneIDi 3508376.
    KEGGi afm:AFUA_6G11910.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    KOi K05349.
    OrthoDBi EOG7H799Q.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 2 hits.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    IPR011658. PA14.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    PF07691. PA14. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SMARTi SM00758. PA14. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiBGLJ_ASPFU
    AccessioniPrimary (citable) accession number: Q4WLY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3