Reviewed, UniProtKB/Swiss-Prot Q4WLG9 (CCPR2_ASPFU)

Names and origin

Protein names

Recommended name:
    Putative heme-binding peroxidase
    EC=1.11.1.-

Gene names

ORF Names:

AFUA_6G13570

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.
Sequence similarities	Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Putative heme-binding peroxidase		PRO_0000055583
Sites
	Active site	38	1	Proton acceptor By similarity
	Active site	178	1	Tryptophan radical intermediate By similarity
	Metal binding	162	1	Iron (heme axial ligand) By similarity
	Site	34	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4WLG9-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 92B81CCD13C991AB	FASTA	322	35,032
	10 20 30 40 50 60 MSKPGDYDAV RKDIIAQLKK PGYDDGSAGP VFVRLAWHSA GTYDLETDTG GSNGAGMRYE 70 80 90 100 110 120 AEGGDPANAG LQHGRAFLEP VKEKHPWITY ADLWTLAGVV AIEALGGPKV VWKPGRTDLV 130 140 150 160 170 180 DDSKVPPRGR LPDATQGAEH LRAVFYRMGF NDQEIVALAG GHTLGRCHID RSGFQGPWVN 190 200 210 220 230 240 NPTRFSNQFF KLLLTLDWKP KTLPNGISQF VYVDPDAEEG DEPLMMLPTD IALKTDPAFR 250 260 270 280 290 300 VWVDKYAADK DLFFDHFAKA FAKLMELGIK RDENDRVINA DNVKGGYISA PKKSNHPTGP 310 320 AKGAQGGCPV AASQGGCPRA KL

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AAHF01000006 Genomic DNA. Translation: EAL89195.1.
RefSeq	XP_751233.1.
3D structure databases
ModBase	Search...
Protein family/group databases
PeroxiBase	2339. AfumCcP01.
Genome annotation databases
GeneID	3508547.
KEGG	afm:AFUA_6G13570.
Phylogenomic databases
HOGENOM	Q4WLG9.
OMA	Q4WLG9. PTRFSNQ.
Family and domain databases
InterPro	IPR002207. Asc_perxdse. IPR002016. Haem_peroxidase_pln/fun/bac. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00459. ASPEROXIDASE. PR00458. PEROXIDASE.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCPR2_ASPFU

Accession

Primary (citable) accession number: Q4WLG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2005
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)