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Q4WL79

- BGLH_ASPFU

UniProt

Q4WL79 - BGLH_ASPFU

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Protein
Probable beta-glucosidase H
Gene
bglH, AFUA_6G14490
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei225 – 2251 By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase H (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase H
Cellobiase H
Gentiobiase H
Gene namesi
Name:bglH
ORF Names:AFUA_6G14490
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 6

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Probable beta-glucosidase H
PRO_0000394879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi473 – 4731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi602 – 6021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi627 – 6271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi664 – 6641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4WL79.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini391 – 535145PA14
Add
BLAST

Sequence similaritiesi

Contains 1 PA14 domain.

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK01238.
OMAiGCESTGV.
OrthoDBiEOG7H799Q.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SMARTiSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Q4WL79-1 [UniParc]FASTAAdd to Basket

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MTPKFDIDYV LANITEDDKI ALLSGSDFWH THAIPKFNVP PIRTTDGPNG    50
IRGTKFFAGV PAACLPCGTA LGATWDRDLL HQAGVLLGKE CLAKGAHCWL 100
GPTINMQRSP LGGRGFESFA EDPHLSGIMA KSIILGCEST GVISTVKHYV 150
GNDQEHERRA VDVLVTPRAL REIYLRPFQI VARDAHPGAL MTSYNKINGK 200
HVVENPAMLD IVRKDWHWDP LIMSDWLGTY TTIDSLNAGL DLEMPGPTRY 250
RGKYIESAMQ ARLIKQSTIS KRARKVLEFV ERASRAPVSA DETGRDFPED 300
RALNRTLCAN SIVLLKNDGN LLPIPKTVKK IALIGSHVKT PAISGGGSAS 350
LEPYYAVSLY DAVVEALPDA EILYEAGAYA HRMLPVIDRM LSNAVIHFYN 400
EPPEKERTLL ATEPVVNTAF QLMDYNAPGL NRALFWATLI GEFTPDVSGL 450
WDFGLTVFGT ATLFIDDEMV IDNATRQTRG TAFFGKGTVQ EVGQKQLTAG 500
QTYKIRIEFG SANTSPMKAI GVVHFGGGAA HLGACLHMDP EQMVANAVRV 550
AAEADYTIVC TGLNRDWESE GFDRPDMDLP PGIDALISSV LDVAADRTVI 600
VNQSGTPVTM PWAHRARGIV QAWYGGNETG HGIADVLFGD VNPSGKLPLS 650
WPADVRHNPT YLNNMSVGGR MLYGEDVYIG YRFYEKVGRE VLFPFGHGLS 700
YTTFHVSPEA TVSPIVFSSD SPPTATVLVK NTGPMAGAQT LQLYIAAPNS 750
ATPRPVKELH GFTKVFLQSG EERSVSIHID RYATSFWDEI EDMWKSEEGV 800
YQVLIGTSSQ EIVSRGEFRV EQTRYWRGV 829
Length:829
Mass (Da):90,990
Last modified:July 5, 2005 - v1
Checksum:i9FC9D770D59A9ED9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000006 Genomic DNA. Translation: EAL89285.1.
RefSeqiXP_751323.1. XM_746230.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00002146; CADAFUAP00002146; CADAFUAG00002146.
GeneIDi3508640.
KEGGiafm:AFUA_6G14490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000006 Genomic DNA. Translation: EAL89285.1 .
RefSeqi XP_751323.1. XM_746230.1.

3D structure databases

ProteinModelPortali Q4WL79.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00002146 ; CADAFUAP00002146 ; CADAFUAG00002146 .
GeneIDi 3508640.
KEGGi afm:AFUA_6G14490.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
KOi K01238.
OMAi GCESTGV.
OrthoDBi EOG7H799Q.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
3.40.50.1700. 2 hits.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SMARTi SM00758. PA14. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiBGLH_ASPFU
AccessioniPrimary (citable) accession number: Q4WL79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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