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Protein

Probable beta-glucosidase H

Gene

bglH

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei225By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase H (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase H
Cellobiase H
Gentiobiase H
Gene namesi
Name:bglH
ORF Names:AFUA_6G14490
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu6g14490

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003948791 – 829Probable beta-glucosidase HAdd BLAST829

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi602N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi664N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00000028

Structurei

3D structure databases

ProteinModelPortaliQ4WL79
SMRiQ4WL79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini389 – 548PA14PROSITE-ProRule annotationAdd BLAST160

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Phylogenomic databases

HOGENOMiHOG000031215
InParanoidiQ4WL79
KOiK05349
OMAiCESTGVI
OrthoDBiEOG092C0SKR

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
3.20.20.300, 2 hits
3.40.50.1700, 2 hits
InterProiView protein in InterPro
IPR026891 Fn3-like
IPR008979 Galactose-bd-like_sf
IPR002772 Glyco_hydro_3_C
IPR036881 Glyco_hydro_3_C_sf
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR037524 PA14/GLEYA
IPR011658 PA14_dom
PfamiView protein in Pfam
PF14310 Fn3-like, 1 hit
PF00933 Glyco_hydro_3, 1 hit
PF01915 Glyco_hydro_3_C, 1 hit
PF07691 PA14, 1 hit
PRINTSiPR00133 GLHYDRLASE3
SMARTiView protein in SMART
SM01217 Fn3_like, 1 hit
SM00758 PA14, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF52279 SSF52279, 2 hits
PROSITEiView protein in PROSITE
PS51820 PA14, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WL79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPKFDIDYV LANITEDDKI ALLSGSDFWH THAIPKFNVP PIRTTDGPNG
60 70 80 90 100
IRGTKFFAGV PAACLPCGTA LGATWDRDLL HQAGVLLGKE CLAKGAHCWL
110 120 130 140 150
GPTINMQRSP LGGRGFESFA EDPHLSGIMA KSIILGCEST GVISTVKHYV
160 170 180 190 200
GNDQEHERRA VDVLVTPRAL REIYLRPFQI VARDAHPGAL MTSYNKINGK
210 220 230 240 250
HVVENPAMLD IVRKDWHWDP LIMSDWLGTY TTIDSLNAGL DLEMPGPTRY
260 270 280 290 300
RGKYIESAMQ ARLIKQSTIS KRARKVLEFV ERASRAPVSA DETGRDFPED
310 320 330 340 350
RALNRTLCAN SIVLLKNDGN LLPIPKTVKK IALIGSHVKT PAISGGGSAS
360 370 380 390 400
LEPYYAVSLY DAVVEALPDA EILYEAGAYA HRMLPVIDRM LSNAVIHFYN
410 420 430 440 450
EPPEKERTLL ATEPVVNTAF QLMDYNAPGL NRALFWATLI GEFTPDVSGL
460 470 480 490 500
WDFGLTVFGT ATLFIDDEMV IDNATRQTRG TAFFGKGTVQ EVGQKQLTAG
510 520 530 540 550
QTYKIRIEFG SANTSPMKAI GVVHFGGGAA HLGACLHMDP EQMVANAVRV
560 570 580 590 600
AAEADYTIVC TGLNRDWESE GFDRPDMDLP PGIDALISSV LDVAADRTVI
610 620 630 640 650
VNQSGTPVTM PWAHRARGIV QAWYGGNETG HGIADVLFGD VNPSGKLPLS
660 670 680 690 700
WPADVRHNPT YLNNMSVGGR MLYGEDVYIG YRFYEKVGRE VLFPFGHGLS
710 720 730 740 750
YTTFHVSPEA TVSPIVFSSD SPPTATVLVK NTGPMAGAQT LQLYIAAPNS
760 770 780 790 800
ATPRPVKELH GFTKVFLQSG EERSVSIHID RYATSFWDEI EDMWKSEEGV
810 820
YQVLIGTSSQ EIVSRGEFRV EQTRYWRGV
Length:829
Mass (Da):90,990
Last modified:July 5, 2005 - v1
Checksum:i9FC9D770D59A9ED9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000006 Genomic DNA Translation: EAL89285.1
RefSeqiXP_751323.1, XM_746230.1

Genome annotation databases

EnsemblFungiiCADAFUAT00002146; CADAFUAP00002146; CADAFUAG00002146
GeneIDi3508640
KEGGiafm:AFUA_6G14490

Similar proteinsi

Entry informationi

Entry nameiBGLH_ASPFU
AccessioniPrimary (citable) accession number: Q4WL79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health