SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4WL66

- ABFB_ASPFU

UniProt

Q4WL66 - ABFB_ASPFU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable alpha-L-arabinofuranosidase B

Gene
abfB, AFUA_6G14620
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Able to hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan By similarity.

Catalytic activityi

Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei184 – 1852Cis-peptide bond By similarity
Binding sitei227 – 2271Substrate By similarity
Active sitei229 – 2291Nucleophile By similarity
Binding sitei230 – 2301Substrate; via amide nitrogen By similarity
Binding sitei304 – 3041Substrate; via amide nitrogen By similarity
Active sitei305 – 3051Proton donor By similarity
Binding sitei424 – 4241Substrate By similarity
Binding sitei426 – 4261Substrate; via amide nitrogen By similarity
Binding sitei427 – 4271Substrate; via amide nitrogen By similarity
Binding sitei443 – 4431Substrate By similarity
Binding sitei471 – 4711Substrate By similarity
Binding sitei476 – 4761Substrate; via amide nitrogen By similarity
Binding sitei496 – 4961Substrate By similarity

GO - Molecular functioni

  1. alpha-L-arabinofuranosidase activity Source: UniProtKB

GO - Biological processi

  1. arabinan catabolic process Source: UniProtKB-UniPathway
  2. arabinose metabolic process Source: UniProtKB
  3. L-arabinose metabolic process Source: InterPro
  4. xylan catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00667.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-L-arabinofuranosidase B (EC:3.2.1.55)
Short name:
ABF B
Short name:
Arabinosidase B
Gene namesi
Name:abfB
ORF Names:AFUA_6G14620
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 6

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 506480Probable alpha-L-arabinofuranosidase BPRO_0000394605Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 39 By similarity
Disulfide bondi89 ↔ 94 By similarity
Disulfide bondi184 ↔ 185 By similarity
Glycosylationi240 – 2401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi409 ↔ 447 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00002338.

Structurei

3D structure databases

ProteinModelPortaliQ4WL66.
SMRiQ4WL66. Positions 27-506.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 343317Catalytic By similarityAdd
BLAST
Regioni344 – 506163ABD By similarityAdd
BLAST

Domaini

Organized into two domains: an N-terminal catalytic domain and a C-terminal arabinose-binding domain (ABD) By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG83819.
HOGENOMiHOG000187007.
OMAiNIVAAKY.
OrthoDBiEOG7DFXNQ.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR015289. A-L-arabinofuranosidase_B_cat.
IPR007934. AbfB.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
PfamiPF05270. AbfB. 1 hit.
PF09206. ArabFuran-catal. 1 hit.
[Graphical view]
SUPFAMiSSF110221. SSF110221. 1 hit.
SSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WL66-1 [UniParc]FASTAAdd to Basket

« Hide

MLPQLSIERA SVFALGLIAT GSLVVAGPCD IYSAGGTPCV AAHSTTRALY    50
SSYSGPLYQV KRGSDGATAD IAPLSAGGVA NAAAQDSFCD GTTCLITIIY 100
DQSGRGNHLT QAPPGGFSGP ESNGYDNLAS AIGAPVTLNG QKAYGVFISP 150
GTGYRNNAAS GTATGDAPEG MYAVLDGTHY NDACCFDYGN AETSSRDTGN 200
GHMEAIYFGD NTIWGTGSGS GPWIMADLEN GLFSGSSPDN NSGDPSISYR 250
FLTAVVKGKQ NQWAIRGANA ASGSLSTFYN GARPSVSGYN PMSKEGAIIL 300
GIGGDNSNGA QGTFYEGVMT SGYPSDATEN SVQANIVAAK YATASLTSGP 350
KLTVGSSISL QATTPGYTTR YIAHSGSTVN TQVVSSSSST TLKQQASWTV 400
RTGLANSDCF SFESRDTPGS FLRHYNFVLQ LSANDGTKQF HEDATFCPQA 450
GLNGQGNSIR SWNYPTRYFR HYNNVLYAAS NGGVHTFDAT SSFNNDVSWV 500
ISTGFA 506
Length:506
Mass (Da):52,548
Last modified:July 5, 2005 - v1
Checksum:i7EE4CD1C4B1A3224
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000006 Genomic DNA. Translation: EAL89298.1.
RefSeqiXP_751336.1. XM_746243.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00002338; CADAFUAP00002338; CADAFUAG00002338.
GeneIDi3508653.
KEGGiafm:AFUA_6G14620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000006 Genomic DNA. Translation: EAL89298.1 .
RefSeqi XP_751336.1. XM_746243.1.

3D structure databases

ProteinModelPortali Q4WL66.
SMRi Q4WL66. Positions 27-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00002338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00002338 ; CADAFUAP00002338 ; CADAFUAG00002338 .
GeneIDi 3508653.
KEGGi afm:AFUA_6G14620.

Phylogenomic databases

eggNOGi NOG83819.
HOGENOMi HOG000187007.
OMAi NIVAAKY.
OrthoDBi EOG7DFXNQ.

Enzyme and pathway databases

UniPathwayi UPA00667 .

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR015289. A-L-arabinofuranosidase_B_cat.
IPR007934. AbfB.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view ]
Pfami PF05270. AbfB. 1 hit.
PF09206. ArabFuran-catal. 1 hit.
[Graphical view ]
SUPFAMi SSF110221. SSF110221. 1 hit.
SSF49899. SSF49899. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiABFB_ASPFU
AccessioniPrimary (citable) accession number: Q4WL66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi