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Protein

Probable glucan 1,3-beta-glucosidase A

Gene

exgA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei211Proton donorBy similarity1
Active sitei308NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cell wall biogenesis/degradation, Polysaccharide degradation
LigandManganese, Metal-binding

Protein family/group databases

CAZyiGH5 Glycoside Hydrolase Family 5

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucan 1,3-beta-glucosidase A (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase 1
Exo-1,3-beta-glucanase A
Gene namesi
Name:exgA
Synonyms:exg1
ORF Names:AFUA_1G03600
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu1g03600

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039353023 – 416Probable glucan 1,3-beta-glucosidase AAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi291 ↔ 415By similarity
Disulfide bondi316 ↔ 342By similarity
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00000394

Structurei

3D structure databases

ProteinModelPortaliQ4WK60
SMRiQ4WK60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000114462
InParanoidiQ4WK60
KOiK01210
OMAiEGAPGWD
OrthoDBiEOG092C22A6

Family and domain databases

InterProiView protein in InterPro
IPR001547 Glyco_hydro_5
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00150 Cellulase, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WK60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFKFSQKAL VALYLVVGLA EAVPSKSRVV SRASTFDYNG IVRGVNIGGW
60 70 80 90 100
LVLEPWITPS IFDNAGDAAV DEWTLTATLG QDQAKAVLSQ HWSTFITQDD
110 120 130 140 150
FQQIAQAGMN HVRIPIGYWA VSSLPDEPYV DGQLEYLDNA ISWAREAGLK
160 170 180 190 200
VVIDLHGAPG SQNGFDNSGR KGPIAWQQGD TVSQTVDAFR ALAERYLPQS
210 220 230 240 250
DVVTAIEALN EPNIPGGVSE AGLRDYYNQI ADVVRQIDPG TSVFLSDGFL
260 270 280 290 300
STESWNGFKT GEDVVMDTHH YEMFDNYLIS LDIDGHVKSA CDFGKQIEGS
310 320 330 340 350
DKPVVVGEWS GAVTDCTKHL NGKGVSTRYQ GEYANNVKYG DCANTTQGSV
360 370 380 390 400
ADLSDQERTD TRRFIEAQLD AYEGKNGWLF WTWKTEGAPG WDMQDLLANG
410
VFPSPLTDRQ FPNQCA
Length:416
Mass (Da):45,687
Last modified:July 5, 2005 - v1
Checksum:iE415DC7AD94260C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000007 Genomic DNA Translation: EAL88072.1
RefSeqiXP_750110.1, XM_745017.1

Genome annotation databases

EnsemblFungiiCADAFUAT00008837; CADAFUAP00008837; CADAFUAG00008837
GeneIDi3507984
KEGGiafm:AFUA_1G03600

Similar proteinsi

Entry informationi

Entry nameiEXGA_ASPFU
AccessioniPrimary (citable) accession number: Q4WK60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health