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Protein

Acetamidase regulatory protein

Gene

amdR

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the expression of genes involved in the catabolism of certain amides, omega amino acids, and lactams.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi26 – 5934Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Acetamidase regulatory protein
Gene namesi
Name:amdR
ORF Names:AFUA_1G03860
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:Afu1g03860.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 772772Acetamidase regulatory proteinPRO_0000233115Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4WK35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000211811.
InParanoidiQ4WK35.
KOiK09244.
OMAiCRIHEKK.
OrthoDBiEOG092C0I2N.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WK35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTAQKNSL SPTGNGVTKR KSGSAACVHC HRRKVRCDAR IVGLPCSNCR
60 70 80 90 100
SSGKTDCRIH EKKKRLAVRS ILNPVPIRCR PPSTSEHVPE ASPPSTISEP
110 120 130 140 150
TAFTTAFRGV QPEAAAPPAS VAPNVQSKAQ HLHSNSYSQT SPQAQECHLP
160 170 180 190 200
PASDRFAEQD AHADFEKRLV KLIDDEEGSG PREIQRGVRA IYVGHELSNM
210 220 230 240 250
SFLIRQQRDK DDDVYHFAGS EIPRRQLKTG HDQLLVDALT LPEPALVDEL
260 270 280 290 300
VQAYFTHVNP GYPIVEEDQF MSQYRNRDPS DPPPILLLQA ILLVGCHVTH
310 320 330 340 350
PKEERDALKA IFFRRAKWLF DNRIERNRDT LVQAALLLTW HSDSPDDDVS
360 370 380 390 400
ANAHYWVGVA ARIATGLGMH RNPVSSRFAP RDRRMWRRLW YILVQLDVMV
410 420 430 440 450
SLSYGRPQAI NLEDSDVSPL TASDFEGCGA RVQTDYVIHF SELCTMISYI
460 470 480 490 500
VRERFGLRVS SERRKAALQE ADEALANWSL RLPDHLRLRA SDMDPWSAML
510 520 530 540 550
HLTYNNFLIL LHRPHPRASA YSDDYGPHDA EICSAAAGVI TSIFEELRLN
560 570 580 590 600
DRLKYLWYSG VHTLFTAMIQ VRVELRFSNP VLAINALRRF DSASCSLREL
610 620 630 640 650
AKYWSHATTI LRLFEDSKRL QKDLRLATSE RSRPFSSTQD QPQAQALDQN
660 670 680 690 700
KNQHQHSSAD APVQPPQPDR LLPSYDSPTP DSTSLPQTAV SPHQNLTFDS
710 720 730 740 750
WIPSTNLATV DPMDQPREFL DWRQLFSFTD PDQPVLPMSM DGLPELEDEW
760 770
RQIYWQETPM SDLLQDGGWM HG
Length:772
Mass (Da):87,414
Last modified:July 5, 2005 - v1
Checksum:i47421977B4717B42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000007 Genomic DNA. Translation: EAL88097.1.
RefSeqiXP_750135.1. XM_745042.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00008577; CADAFUAP00008577; CADAFUAG00008577.
GeneIDi3507372.
KEGGiafm:AFUA_1G03860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000007 Genomic DNA. Translation: EAL88097.1.
RefSeqiXP_750135.1. XM_745042.1.

3D structure databases

ProteinModelPortaliQ4WK35.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00008577; CADAFUAP00008577; CADAFUAG00008577.
GeneIDi3507372.
KEGGiafm:AFUA_1G03860.

Organism-specific databases

EuPathDBiFungiDB:Afu1g03860.

Phylogenomic databases

HOGENOMiHOG000211811.
InParanoidiQ4WK35.
KOiK09244.
OMAiCRIHEKK.
OrthoDBiEOG092C0I2N.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR007219. Transcription_factor_dom_fun.
IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF04082. Fungal_trans. 1 hit.
PF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00906. Fungal_trans. 1 hit.
SM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMDR_ASPFU
AccessioniPrimary (citable) accession number: Q4WK35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.