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Protein

RNA polymerase II subunit A C-terminal domain phosphatase ssu72

Gene

ssu72

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase ssu72 (EC:3.1.3.16)
Short name:
CTD phosphatase ssu72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:ssu72
ORF Names:AFUA_2G03760
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiFungiDB:Afu2g03760.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002556031 – 287RNA polymerase II subunit A C-terminal domain phosphatase ssu72Add BLAST287

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00002032.

Structurei

3D structure databases

ProteinModelPortaliQ4WHY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 28Pro-richAdd BLAST14

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

HOGENOMiHOG000183445.
InParanoidiQ4WHY5.
KOiK15544.
OMAiWQERWPN.
OrthoDBiEOG092C4UKX.

Family and domain databases

InterProiView protein in InterPro
IPR006811. RNA_pol_II_suA.
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiView protein in Pfam
PF04722. Ssu72. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4WHY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHDPRLSSA GTATPNPPPP PPPPPPEPST TGTGETQAAE PSAPAQSSDS
60 70 80 90 100
FKLKFCTVCA SNQNRSMEAH LRLSTAPSPF PVISFGTGSL VRLPGPSITQ
110 120 130 140 150
PNVYNFNTTS YSQMYDELLA KDERLYRNNG LLNMLDRNRN LKWGPERFQD
160 170 180 190 200
WVPGMPRVDH VSKGDKGALG TEGGTVDVII TCEERCWDAV VDDLMNKGAA
210 220 230 240 250
LNRPVHVFNV DIRDNHEEAL VGGKAILELA TRLNDAATQE RKIHGAEGWE
260 270 280
NGNGEARRSF DERVPEILAS WQEKWPNLPA LWTLAWL
Length:287
Mass (Da):31,559
Last modified:July 5, 2005 - v1
Checksum:i5366D17B18D8BC1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000008 Genomic DNA. Translation: EAL87470.1.
RefSeqiXP_749508.1. XM_744415.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00003794; CADAFUAP00003794; CADAFUAG00003794.
GeneIDi3506785.
KEGGiafm:AFUA_2G03760.

Similar proteinsi

Entry informationi

Entry nameiSSU72_ASPFU
AccessioniPrimary (citable) accession number: Q4WHY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2005
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families