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Q4WHY5

- SSU72_ASPFU

UniProt

Q4WHY5 - SSU72_ASPFU

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Protein
RNA polymerase II subunit A C-terminal domain phosphatase ssu72
Gene
ssu72, AFUA_2G03760
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb1) By similarity.
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase ssu72 (EC:3.1.3.16)
Short name:
CTD phosphatase ssu72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:ssu72
ORF Names:AFUA_2G03760
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 2

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287RNA polymerase II subunit A C-terminal domain phosphatase ssu72
PRO_0000255603Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Protein-protein interaction databases

STRINGi5085.CADAFUAP00003794.

Structurei

3D structure databases

ProteinModelPortaliQ4WHY5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 2814Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
KOiK15544.
OMAiWQERWPN.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WHY5-1 [UniParc]FASTAAdd to Basket

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MAHDPRLSSA GTATPNPPPP PPPPPPEPST TGTGETQAAE PSAPAQSSDS    50
FKLKFCTVCA SNQNRSMEAH LRLSTAPSPF PVISFGTGSL VRLPGPSITQ 100
PNVYNFNTTS YSQMYDELLA KDERLYRNNG LLNMLDRNRN LKWGPERFQD 150
WVPGMPRVDH VSKGDKGALG TEGGTVDVII TCEERCWDAV VDDLMNKGAA 200
LNRPVHVFNV DIRDNHEEAL VGGKAILELA TRLNDAATQE RKIHGAEGWE 250
NGNGEARRSF DERVPEILAS WQEKWPNLPA LWTLAWL 287
Length:287
Mass (Da):31,559
Last modified:July 5, 2005 - v1
Checksum:i5366D17B18D8BC1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000008 Genomic DNA. Translation: EAL87470.1.
RefSeqiXP_749508.1. XM_744415.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00003794; CADAFUAP00003794; CADAFUAG00003794.
GeneIDi3506785.
KEGGiafm:AFUA_2G03760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000008 Genomic DNA. Translation: EAL87470.1 .
RefSeqi XP_749508.1. XM_744415.1.

3D structure databases

ProteinModelPortali Q4WHY5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00003794.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00003794 ; CADAFUAP00003794 ; CADAFUAG00003794 .
GeneIDi 3506785.
KEGGi afm:AFUA_2G03760.

Phylogenomic databases

eggNOGi COG5211.
HOGENOMi HOG000183445.
KOi K15544.
OMAi WQERWPN.
OrthoDBi EOG7GTTG0.

Family and domain databases

InterProi IPR006811. RNA_pol_II_suA.
[Graphical view ]
PANTHERi PTHR20383. PTHR20383. 1 hit.
Pfami PF04722. Ssu72. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiSSU72_ASPFU
AccessioniPrimary (citable) accession number: Q4WHY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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