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Q4WHU1 (HPPD1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable 4-hydroxyphenylpyruvate dioxygenase 1

Short name=4HPPD 1
Short name=HPD 1
Short name=HPPDase 1
EC=1.13.11.27
Gene names
ORF Names:AFUA_2G04200
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaemitosporic TrichocomaceaeAspergillus

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactor

Binds 1 iron ion per subunit By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.

Sequence similarities

Belongs to the 4HPPD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Probable 4-hydroxyphenylpyruvate dioxygenase 1
PRO_0000088401

Sites

Metal binding2041Iron By similarity
Metal binding2871Iron By similarity
Metal binding3701Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4WHU1 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 849FED016DA354AC

FASTA40345,534
        10         20         30         40         50         60 
MAPSAISTSP PPTDRVSSSL ASYKGYDHVH WYVGNAKQAA SYYITRMGFK RIAYRGLETG 

        70         80         90        100        110        120 
CRSVCSHVVR NGDITFILTS PLRSLDQVDR FPPEEQELLK EIHAHLEKHG DGVKDVAFEV 

       130        140        150        160        170        180 
DSVDSVFYAA TNNGAKIVSQ PRTLEDDNGQ VRVATIQTYG ETTHTLVERG SYHGAFLPGY 

       190        200        210        220        230        240 
RMETGVEDPI SQLLPGVHLN RIDHCVGNQD WDEMDKVCEY YEKALGFHRF WSVDDKQICT 

       250        260        270        280        290        300 
EYSALKSIVM ASPNEVVKMP INEPAKGKKQ SQIEEYVDFY NGAGVQHIAL LTDDIIRDIT 

       310        320        330        340        350        360 
NLKARGVEFI KVPDTYYEDI KVRLKKAGLT LHEDFETIRS LDILIDFDEG GYLLQLFTKH 

       370        380        390        400 
LMDRPTVFIE IIQRHNFSGF GAGNFKSLFE AIEREQALRG NLV 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000008 Genomic DNA. Translation: EAL87514.1.
RefSeqXP_749552.1. XM_744459.1.

3D structure databases

ProteinModelPortalQ4WHU1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4WHU1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00003294; CADAFUAP00003294; CADAFUAG00003294.
GeneID3507145.
KEGGafm:AFUA_2G04200.

Phylogenomic databases

eggNOGfuNOG06871.
GeneTreeEFGT00050000003777.
HOGENOMHBG680392.
OMAHCVGNVE.
OrthoDBEOG4CC78T.

Family and domain databases

InterProIPR005956. 4OHPhenylPyrv_dOase.
IPR004360. Glyas_Fos-R_dOase.
[Graphical view]
KOK00457.
PANTHERPTHR11959. HPP_dOase. 1 hit.
PfamPF00903. Glyoxalase. 1 hit.
[Graphical view]
PIRSFPIRSF009283. HPP_dOase. 1 hit.
TIGRFAMsTIGR01263. 4HPPD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPPD1_ASPFU
AccessionPrimary (citable) accession number: Q4WHU1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families