Reviewed, UniProtKB/Swiss-Prot Q4WHU1 (HPPD1_ASPFU)

Names and origin

Protein names

Recommended name:
    Probable 4-hydroxyphenylpyruvate dioxygenase 1
      Short name=HPPDase 1
      Short name=4HPPD 1
      Short name=HPD 1
    EC=1.13.11.27

Gene names

ORF Names:

AFUA_2G04200

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 403	403	Probable 4-hydroxyphenylpyruvate dioxygenase 1		PRO_0000088401
Sites
	Metal binding	204	1	Iron By similarity
	Metal binding	287	1	Iron By similarity
	Metal binding	370	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4WHU1-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 849FED016DA354AC	FASTA	403	45,534
	10 20 30 40 50 60 MAPSAISTSP PPTDRVSSSL ASYKGYDHVH WYVGNAKQAA SYYITRMGFK RIAYRGLETG 70 80 90 100 110 120 CRSVCSHVVR NGDITFILTS PLRSLDQVDR FPPEEQELLK EIHAHLEKHG DGVKDVAFEV 130 140 150 160 170 180 DSVDSVFYAA TNNGAKIVSQ PRTLEDDNGQ VRVATIQTYG ETTHTLVERG SYHGAFLPGY 190 200 210 220 230 240 RMETGVEDPI SQLLPGVHLN RIDHCVGNQD WDEMDKVCEY YEKALGFHRF WSVDDKQICT 250 260 270 280 290 300 EYSALKSIVM ASPNEVVKMP INEPAKGKKQ SQIEEYVDFY NGAGVQHIAL LTDDIIRDIT 310 320 330 340 350 360 NLKARGVEFI KVPDTYYEDI KVRLKKAGLT LHEDFETIRS LDILIDFDEG GYLLQLFTKH 370 380 390 400 LMDRPTVFIE IIQRHNFSGF GAGNFKSLFE AIEREQALRG NLV

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000008 Genomic DNA. Translation: EAL87514.1.
RefSeq	XP_749552.1.
3D structure databases
SMR	Q4WHU1. Positions 21-387.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4WHU1.
Genome annotation databases
GeneID	3507145.
KEGG	afm:AFUA_2G04200.
Phylogenomic databases
eggNOG	fuNOG06871.
HOGENOM	HBG680392.
OMA	VQDRPTV.
OrthoDB	EOG9RZ0GJ.
Enzyme and pathway databases
BRENDA	1.13.11.27. 18841.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD1_ASPFU

Accession

Primary (citable) accession number: Q4WHU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	July 5, 2005
Last modified:	February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)