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Protein

Histone acetyltransferase esa1

Gene

esa1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei337Important for catalytic activityBy similarity1
Active sitei371Proton donor/acceptorBy similarity1
Binding sitei375Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 253C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase esa1 (EC:2.3.1.48By similarity)
Gene namesi
Name:esa1
ORF Names:AFUA_2G05530
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu2g05530

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515521 – 483Histone acetyltransferase esa1Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei295N6-acetyllysine; by autocatalysisBy similarity1

Post-translational modificationi

Autoacetylation at Lys-295 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ4WHG1

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00002202

Structurei

3D structure databases

ProteinModelPortaliQ4WHG1
SMRiQ4WHG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 471MYST-type HATPROSITE-ProRule annotationAdd BLAST277

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni336 – 340Acetyl-CoA bindingBy similarity5
Regioni345 – 351Acetyl-CoA bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi278 – 299ESA1-RPD3 motifBy similarityAdd BLAST22

Domaini

The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.By similarity

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 253C2HC MYST-type; degeneratePROSITE-ProRule annotationAdd BLAST26

Phylogenomic databases

HOGENOMiHOG000182457
InParanoidiQ4WHG1
KOiK11304
OMAiMNMVKYW
OrthoDBiEOG092C043Q

Family and domain databases

CDDicd00024 CHROMO, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR037995 Esa1/KAT5/Tip60
IPR002717 HAT_MYST-type
IPR025995 Tudor-knot
IPR036388 WH-like_DNA-bd_sf
PANTHERiPTHR10615:SF124 PTHR10615:SF124, 1 hit
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
PF11717 Tudor-knot, 1 hit
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 2 hits
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WHG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLMFALLQ DGELRKAEIL SIRQRKDGPS FYVHYVDFNK RLDEWIDASR
60 70 80 90 100
LDLSHEVEWP QPEKPEKKKT GVGNKAPSKN AQKRARADSR DVSATPDLLT
110 120 130 140 150
GKNVNVGKAQ RPSKAGGKEN RDGTPLSMPI VTAEAISTDG TPKAESDDVE
160 170 180 190 200
MVDVSFTDGK SIKEEERALG LMSREEEIER LRTSGSMTQN PTEIHRVRNL
210 220 230 240 250
NRLQMGKYDI EPWYFSPYPA SFSDADIIYI DEFCLSYFDD KRAFERHRTK
260 270 280 290 300
CTLVHPPGNE IYRDDYISFF EVDGRRQRTW CRNLCLLSKL FLDHKTLYYD
310 320 330 340 350
VDPFLFYCMC TRDETGCHLV GYFSKEKDSA EGYNLACILT LPQYQRRGFG
360 370 380 390 400
RLLISFSYEL SKREGKLGSP EKPLSDLGLL GYRQYWRETL VEILMEPGRE
410 420 430 440 450
TVSENELALL TSMTEKDVHE TLVVLNMLRY YKGNWVIVLT DYVVEQHKKR
460 470 480
LEKEKLKGAR KIDPARLQWK PPVFTASSRT WNW
Length:483
Mass (Da):55,969
Last modified:July 5, 2005 - v1
Checksum:i8EBF3CDAE55CE6F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000008 Genomic DNA Translation: EAL87644.1
RefSeqiXP_749682.1, XM_744589.1

Genome annotation databases

EnsemblFungiiCADAFUAT00003874; CADAFUAP00003874; CADAFUAG00003874
GeneIDi3506677
KEGGiafm:AFUA_2G05530

Similar proteinsi

Entry informationi

Entry nameiESA1_ASPFU
AccessioniPrimary (citable) accession number: Q4WHG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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