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Protein

Riboflavin kinase

Gene

fmn1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.By similarity

Catalytic activityi

ATP + riboflavin = ADP + FMN.

Cofactori

Zn2+By similarity, Mg2+By similarityNote: Zinc or magnesium.By similarity

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin kinase (fmn1)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Magnesium or zincBy similarity1
Active sitei116NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Flavoprotein, FMN, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
Flavin mononucleotide kinase 1
Gene namesi
Name:fmn1
ORF Names:AFUA_2G05820
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiFungiDB:Afu2g05820.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003018341 – 214Riboflavin kinaseAdd BLAST214

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00002232.

Structurei

3D structure databases

ProteinModelPortaliQ4WHD2.
SMRiQ4WHD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the flavokinase family.Curated

Phylogenomic databases

HOGENOMiHOG000260803.
InParanoidiQ4WHD2.
KOiK00861.
OMAiSIEIHIM.
OrthoDBiEOG092C5F1Q.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
InterProiView protein in InterPro
IPR023468. Riboflavin_kinase.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiView protein in Pfam
PF01687. Flavokinase. 1 hit.
SMARTiView protein in SMART
SM00904. Flavokinase. 1 hit.
SUPFAMiSSF82114. SSF82114. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4WHD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPDGPRDPV AGPDSGPEPP YPVRLSGPVI KGFGRGSKEL GIPTANIPAE
60 70 80 90 100
GLEEYPDLQV GVYYGVVALD PAKFQYQEGQ GSTSTSSTGG AEAAVLPAVL
110 120 130 140 150
SIGYNPFYKN KTKSIEIHIM PPLSSPSPTA DGAGEVKFHK LPDFYGTQLK
160 170 180 190 200
LLILGYIRPE YDYVSLEALI EDIRVDCEVA RKSLQRPAYA CYIDGDEKEC
210
SDVVREQRRW LVTF
Length:214
Mass (Da):23,367
Last modified:July 5, 2005 - v1
Checksum:i35D2BD8FA89627BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000008 Genomic DNA. Translation: EAL87673.1.
RefSeqiXP_749711.1. XM_744618.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00003403; CADAFUAP00003403; CADAFUAG00003403.
GeneIDi3507072.
KEGGiafm:AFUA_2G05820.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRIFK_ASPFU
AccessioniPrimary (citable) accession number: Q4WHD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2005
Last modified: July 5, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families