Reviewed, UniProtKB/Swiss-Prot Q4WHB7 (JHD1_ASPFU)

Names and origin

Protein names

Recommended name:
    JmjC domain-containing histone demethylation protein 1
    EC=1.14.11.27
Alternative name(s):
    [Histone-H3]-lysine-36 demethylase 1

Gene names

Name:	jhd1
ORF Names:	AFUA_2G05970

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	1418 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.
Catalytic activity	Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2. Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.
Cofactor	Binds 1 Fe2+ ion per subunit By similarity.
Subcellular location	Nucleus By similarity.
Domain	The JmjC domain mediates the demethylation activity By similarity.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 JmjC domain. Contains 1 PHD-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Iron Metal-binding Zinc
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1418	1418	JmjC domain-containing histone demethylation protein 1		PRO_0000226792
Regions
	Domain	588 – 746	159	JmjC
	Zinc finger	331 – 391	61	PHD-type
Sites
	Metal binding	642	1	Iron; catalytic By similarity
	Metal binding	644	1	Iron; catalytic By similarity
	Metal binding	714	1	Iron; catalytic By similarity
	Binding site	639	1	Substrate By similarity
	Binding site	659	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4WHB7-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 5575A6C161A1C82C	FASTA	1,418	157,353
	10 20 30 40 50 60 MIGATSFLNH SGPRPPRYRT PSPPRRAVEP ISPFTTTTDF RASWIDRGDS QAASYDRDRV 70 80 90 100 110 120 TSNNDVYSST NRGSHGRTSH GRSSSTIDTL ATIALATSPT FAPLSYRPPS QDPTPAMPLF 130 140 150 160 170 180 PSQSIESTER PAKRPRSEKS PSPLHQPQTT VAPDANPSST FDSMKTDAEL LLNFARPSNF 190 200 210 220 230 240 QPAAFYPSKR VSIDESYHPH YGEEPKSHFR AGLGSTYILP DGEKSAYHTS ANTAFPASRM 250 260 270 280 290 300 RSQSDGSAFI SRPVIQGVRP NTSSSTLPPI VWQEEEGNAK TGPGPPSTKF PGAETRYENS 310 320 330 340 350 360 VFTGIDTGAD RASLDVPPRG DDDTESDENN QANCAACNLV RIPVDSEEQG DVTWISCDGC 370 380 390 400 410 420 KQWFHIVCAG FKNDREIRTV DKFICRRCRP IHGQTTFVRK SSRARTAIDY AGLNQGLVKA 430 440 450 460 470 480 ASDSLEHHYI EPIREGKIRF LPDNFPRMRP ELVTAEYFER GSGMTEPIVI PAHLNTRDSI 490 500 510 520 530 540 PIVDPEFDSL VQEATSQEMF DELLEHLPEE GKDFETVIDC GQDQLDMVVP QGLTVRAVAE 550 560 570 580 590 600 LYGPEERVEV IDVKSQQGED KRWNMQKWAD YYESTGSKVV RNVISLEVSQ SKLGKLIRRP 610 620 630 640 650 660 KIVRDLDLQD AVWPEELKAI GDYPKVQFYC LMSVADCYTD FHIDFGGSSV YYHILKGKKT 670 680 690 700 710 720 FFFIPPKDKH LKKYEDWCNS PAQDSTFLGD QTKECYRVDL SEGDTMLIPS GWIHAVWTPT 730 740 750 760 770 780 NSLVIGGNFL TRLNYGMQIK VAKIEKDTKV PRKFRYPFFQ RIQWYTALKY LEDDPIPQSV 790 800 810 820 830 840 LNAFAEDENY RFHRAYPIYY EFGERENKAP AGDPYHNSRF YSQAELEGLP DLAKYLLRTA 850 860 870 880 890 900 LIASGYMVEG VTMDARNAVK RSIPKGQGDP IDTVRKFGIW VAWKRGNEKA PQWTRPGVVE 910 920 930 940 950 960 SNAKLSLTEK KPAGRPSRRS ERNAEGQRMY AERQAVQRPL EQPPDLTNGL SSEESSSAPS 970 980 990 1000 1010 1020 TVEIPQSTVI STLPGTETKE LKEEIAQKPR SIHRSSGLGP KRVACDACRK RRIRCRHKDE 1030 1040 1050 1060 1070 1080 HNDTISAKQT TFGTFPAGVQ SSLAHDAASA LNSLAAIASE AGFQDAANGH GLERLEGSGN 1090 1100 1110 1120 1130 1140 YSTAILSTPN AATSKVHDGS PEGLNTGKKG RSKACDDCRK SKRRCIHDEY GRIDPIKAQE 1150 1160 1170 1180 1190 1200 RSKPRATASA KRPRPPQEED AAFTLNKRPK QESTSPVARP ASLFRAEGDM SHTQRPVDLE 1210 1220 1230 1240 1250 1260 ASSYFGTAHD HNGIAQTKLT SAVGQTSYAS PPAFQSDTVV MEVAGQGVSK PTASLVSPPT 1270 1280 1290 1300 1310 1320 SQADETDVPP EQDAEKDNHV VYYTPTTSSR HSSRQPRHVD RYVPESQPAK AVKTTHTPSK 1330 1340 1350 1360 1370 1380 RRASCSGPTT ARRVTPGAQG SSKKPASRPS SSHAKKGVSP VTEKKFDRMT TTSTSPGHKG 1390 1400 1410 AKRERTAIAD DEPDAESLRL IRELQEQEFG LRKRTTRV

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000008 Genomic DNA. Translation: EAL87688.1.
RefSeq	XP_749726.1.
3D structure databases
SMR	Q4WHB7. Positions 332-406, 439-774.
ModBase	Search...
Genome annotation databases
GeneID	3506876.
KEGG	afm:AFUA_2G05970.
Phylogenomic databases
eggNOG	fuNOG04730.
HOGENOM	HBG330578.
OrthoDB	EOG9H47M1.
PhylomeDB	Q4WHB7.
Enzyme and pathway databases
BRENDA	1.14.11.27. 18841.
Family and domain databases
InterPro	IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. [Graphical view]
Pfam	PF02373. JmjC. 1 hit. PF00628. PHD. 1 hit. [Graphical view]
SMART	SM00558. JmjC. 1 hit. SM00249. PHD. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

JHD1_ASPFU

Accession

Primary (citable) accession number: Q4WHB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 5, 2005
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)