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Protein

Endo-1,4-beta-xylanase xynf11a

Gene

xlnA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.1 Publication

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

pH dependencei

Optimum pH is 6.0. Stable in the pH range from 4.0 to 8.0.1 Publication

Temperature dependencei

Optimum temperature is 60 degrees Celsius. Around 53 percent activity is retained at 70 degrees Celsius. Stable from 30 to 60 degrees Celsius with maximum stability at 30 degrees Celsius.1 Publication

Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei124NucleophilePROSITE-ProRule annotation1
Active sitei215Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

  • endo-1,4-beta-xylanase activity Source: UniProtKB

GO - Biological processi

  • xylan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114.

Protein family/group databases

CAZyiGH11. Glycoside Hydrolase Family 11.
mycoCLAPiXYN11A_ASPFU.

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase xynf11a (EC:3.2.1.8)
Short name:
Xylanase xynf11a
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase xynf11a
Gene namesi
Name:xlnA
Synonyms:xynf11a
ORF Names:AFUA_3G00320
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiFungiDB:Afu3g00320.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000039316119 – 228Endo-1,4-beta-xylanase xynf11aAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ4WG11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 228GH11PROSITE-ProRule annotationAdd BLAST189

Sequence similaritiesi

Contains 1 GH11 (glycosyl hydrolase family 11) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000179135.
InParanoidiQ4WG11.
KOiK01181.
OMAiWNPGTGR.
OrthoDBiEOG092C4K17.

Family and domain databases

Gene3Di2.60.120.180. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR013319. GH11/12.
IPR018208. GH11_AS_1.
IPR033119. GH11_AS_2.
IPR033123. GH11_dom.
IPR001137. Glyco_hydro_11.
[Graphical view]
PfamiPF00457. Glyco_hydro_11. 1 hit.
[Graphical view]
PRINTSiPR00911. GLHYDRLASE11.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00776. GH11_1. 1 hit.
PS00777. GH11_2. 1 hit.
PS51761. GH11_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WG11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFSYLLLA CSAIGALAAP VEPETTSFNE TALHEFAERA GTPSSTGWNN
60 70 80 90 100
GYYYSFWTDG GGDVTYTNGA GGSYSVNWRN VGNFVGGKGW NPGSARTINY
110 120 130 140 150
GGSFNPSGNG YLAVYGWTTN PLIEYYVVES YGTYNPGSGG TFRGTVNTDG
160 170 180 190 200
GTYNIYTAVR YNAPSIEGTK TFTQYWSVRT SKRTGGTVTM ANHFNAWSRL
210 220
GMNLGTHNYQ IVATEGYQSS GSASITVY
Length:228
Mass (Da):24,494
Last modified:July 5, 2005 - v1
Checksum:i7DBED47138DA238F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ156553 mRNA. Translation: ABA40419.1.
EF375873 Genomic DNA. Translation: ABN48478.1.
AAHF01000010 Genomic DNA. Translation: EAL86316.1.
RefSeqiXP_748354.1. XM_743261.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00000232; CADAFUAP00000232; CADAFUAG00000232.
GeneIDi3505821.
KEGGiafm:AFUA_3G00320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ156553 mRNA. Translation: ABA40419.1.
EF375873 Genomic DNA. Translation: ABN48478.1.
AAHF01000010 Genomic DNA. Translation: EAL86316.1.
RefSeqiXP_748354.1. XM_743261.1.

3D structure databases

ProteinModelPortaliQ4WG11.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH11. Glycoside Hydrolase Family 11.
mycoCLAPiXYN11A_ASPFU.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00000232; CADAFUAP00000232; CADAFUAG00000232.
GeneIDi3505821.
KEGGiafm:AFUA_3G00320.

Organism-specific databases

EuPathDBiFungiDB:Afu3g00320.

Phylogenomic databases

HOGENOMiHOG000179135.
InParanoidiQ4WG11.
KOiK01181.
OMAiWNPGTGR.
OrthoDBiEOG092C4K17.

Enzyme and pathway databases

UniPathwayiUPA00114.

Family and domain databases

Gene3Di2.60.120.180. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR013319. GH11/12.
IPR018208. GH11_AS_1.
IPR033119. GH11_AS_2.
IPR033123. GH11_dom.
IPR001137. Glyco_hydro_11.
[Graphical view]
PfamiPF00457. Glyco_hydro_11. 1 hit.
[Graphical view]
PRINTSiPR00911. GLHYDRLASE11.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00776. GH11_1. 1 hit.
PS00777. GH11_2. 1 hit.
PS51761. GH11_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYNA_ASPFU
AccessioniPrimary (citable) accession number: Q4WG11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: July 5, 2005
Last modified: October 5, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.