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Protein

Endo-1,4-beta-xylanase xynf11a

Gene

xlnA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.1 Publication

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

pH dependencei

Optimum pH is 6.0. Stable in the pH range from 4.0 to 8.0.1 Publication

Temperature dependencei

Optimum temperature is 60 degrees Celsius. Around 53 percent activity is retained at 70 degrees Celsius. Stable from 30 to 60 degrees Celsius with maximum stability at 30 degrees Celsius.1 Publication

Pathwayi: xylan degradation

This protein is involved in the pathway xylan degradation, which is part of Glycan degradation.
View all proteins of this organism that are known to be involved in the pathway xylan degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei124NucleophilePROSITE-ProRule annotation1
Active sitei215Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

  • endo-1,4-beta-xylanase activity Source: UniProtKB

GO - Biological processi

  • xylan catabolic process Source: UniProtKB

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Enzyme and pathway databases

UniPathwayiUPA00114

Protein family/group databases

CAZyiGH11 Glycoside Hydrolase Family 11
mycoCLAPiXYN11A_ASPFU

Names & Taxonomyi

Protein namesi
Recommended name:
Endo-1,4-beta-xylanase xynf11a (EC:3.2.1.8)
Short name:
Xylanase xynf11a
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase xynf11a
Gene namesi
Name:xlnA
Synonyms:xynf11a
ORF Names:AFUA_3G00320
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu3g00320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000039316119 – 228Endo-1,4-beta-xylanase xynf11aAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00004715

Structurei

3D structure databases

ProteinModelPortaliQ4WG11
SMRiQ4WG11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 228GH11PROSITE-ProRule annotationAdd BLAST189

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000179135
InParanoidiQ4WG11
KOiK01181
OMAiMQNHFNA
OrthoDBiEOG092C4K17

Family and domain databases

Gene3Di2.60.120.180, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR013319 GH11/12
IPR018208 GH11_AS_1
IPR033119 GH11_AS_2
IPR033123 GH11_dom
IPR001137 Glyco_hydro_11
PfamiView protein in Pfam
PF00457 Glyco_hydro_11, 1 hit
PRINTSiPR00911 GLHYDRLASE11
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00776 GH11_1, 1 hit
PS00777 GH11_2, 1 hit
PS51761 GH11_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WG11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFSYLLLA CSAIGALAAP VEPETTSFNE TALHEFAERA GTPSSTGWNN
60 70 80 90 100
GYYYSFWTDG GGDVTYTNGA GGSYSVNWRN VGNFVGGKGW NPGSARTINY
110 120 130 140 150
GGSFNPSGNG YLAVYGWTTN PLIEYYVVES YGTYNPGSGG TFRGTVNTDG
160 170 180 190 200
GTYNIYTAVR YNAPSIEGTK TFTQYWSVRT SKRTGGTVTM ANHFNAWSRL
210 220
GMNLGTHNYQ IVATEGYQSS GSASITVY
Length:228
Mass (Da):24,494
Last modified:July 5, 2005 - v1
Checksum:i7DBED47138DA238F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ156553 mRNA Translation: ABA40419.1
EF375873 Genomic DNA Translation: ABN48478.1
AAHF01000010 Genomic DNA Translation: EAL86316.1
RefSeqiXP_748354.1, XM_743261.1

Genome annotation databases

EnsemblFungiiCADAFUAT00000232; CADAFUAP00000232; CADAFUAG00000232
GeneIDi3505821
KEGGiafm:AFUA_3G00320

Entry informationi

Entry nameiXYNA_ASPFU
AccessioniPrimary (citable) accession number: Q4WG11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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