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Protein

Endochitinase A1

Gene

chiA1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation (By similarity).By similarity

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Enzyme regulationi

The cyclic peptide natural product argifin acts as a specific inhibitor.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34InhibitorBy similarity1
Binding sitei124Inhibitor; via amide nitrogenBy similarity1
Binding sitei125InhibitorBy similarity1
Active sitei174Proton donorPROSITE-ProRule annotation1
Binding sitei207InhibitorBy similarity1
Binding sitei312InhibitorBy similarity1

GO - Molecular functioni

  • chitinase activity Source: AspGD
  • chitin binding Source: UniProtKB-KW

GO - Biological processi

  • autolysis Source: AspGD
  • chitin catabolic process Source: UniProtKB-KW
  • polysaccharide catabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Endochitinase A1 (EC:3.2.1.14)
Alternative name(s):
Chitinase A1
Gene namesi
Name:chiA1
Synonyms:chi1
ORF Names:AFUA_5G03760
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 5, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu5g03760

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000042981623 – 863Endochitinase A1Add BLAST841
PropeptideiPRO_0000429817864 – 888Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi780N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi863GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00005116

Structurei

3D structure databases

ProteinModelPortaliQ4WEP7
SMRiQ4WEP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni170 – 174Inhibitor bindingBy similarity5
Regioni230 – 232Inhibitor bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi346 – 752Ser/Thr-richAdd BLAST407

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000159794
InParanoidiQ4WEP7
KOiK01183
OMAiFDFIWVQ
OrthoDBiEOG092C4MM9

Family and domain databases

InterProiView protein in InterPro
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS01095 CHITINASE_18, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WEP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSKLSFVA TAVAALAPLA SAFDASSRSN LAIYWGQGPN QLRLSHFCQE
60 70 80 90 100
TSLDIINIGF INYFPDMSPG HWPGSNFGNQ CDGSVYVTND GVVTKLLSGC
110 120 130 140 150
HQIMEDIPIC QAAGKKVLLS IGGAYPPDQS ILSEDSAVAF ATFLWGAFGP
160 170 180 190 200
VAEGWEGPRP FGDVVVDGFD FDIEHNGGFG YATMANTFRQ YFNQVPERKF
210 220 230 240 250
YLSAAPQCII PDAQLSDAIF NAAFDFIWIQ YYNTAACSAK SFIDTSLGTF
260 270 280 290 300
NFDAWVTVLK ASASKDAKLY VGLPASETAA NQGYYLTPDE VESLVSTYMD
310 320 330 340 350
RYPDTFGGIM LWEATASENN QIDGAPYADH MKDILLHCDP SPPVTSSSAI
360 370 380 390 400
PSSTPVTTPS PSSSAVPSST PAVSETPSPS SSAVPSSTPV ASSTPVVPGT
410 420 430 440 450
SASSSPVSSS SAVASSTPVV PGTSASSSPV SSSSAVASST PVVPGTSTSP
460 470 480 490 500
STPVIPGTSA SSSPVSSSSA VASSTPVVPG TSASSSPVSS SSAVASSTPV
510 520 530 540 550
VPGTSASSSP VSSSSAVASS TPVVPGTSVP SSTPAIPGGS SSSSEAVASS
560 570 580 590 600
TPLVTLTLTV SPTPAPSSSE SSSTDLSSST QTDVGTAPSQ PAGPSTTATA
610 620 630 640 650
TTSSSSSSTD ESSTTVGSGN GNGSGSTTTT AATDSITAAP TATSSATATG
660 670 680 690 700
ATSEPVTITT IIVTSYIDIC PTGFTTVTTT YTTTYCPGTN TATATATVTN
710 720 730 740 750
PPSGPGGAGS QTTAPTVPEG WTTTVTICTQ CAAKPTTVTL TLPVTETGST
760 770 780 790 800
STDAVPAPPA ATGEGSNPTQ PSGASPTGGN GSFSEEPVPP PAVTQVSTST
810 820 830 840 850
EIVTLVRPTS SRPLILGTGT VHPSSTLAVK PSAKPSGQNS GSSSHVPIPP
860 870 880
SYTQEAVSPL STGAASRVTG LGHGLVLTVL TLSAFFVL
Length:888
Mass (Da):88,628
Last modified:July 5, 2005 - v1
Checksum:iEDB4FADAF7281D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000011 Genomic DNA Translation: EAL85930.1
RefSeqiXP_747968.1, XM_742875.1

Genome annotation databases

EnsemblFungiiCADAFUAT00002927; CADAFUAP00002927; CADAFUAG00002927
GeneIDi3505591
KEGGiafm:AFUA_5G03760

Similar proteinsi

Entry informationi

Entry nameiCHIA1_ASPFU
AccessioniPrimary (citable) accession number: Q4WEP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health