Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q4WEI5 (HAT2_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase type B subunit 2
Gene names
Name:hat2
ORF Names:AFUA_5G03130
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing By similarity.

Subunit structure

Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.

Contains 6 WD repeats.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
WD repeat
   Molecular functionChromatin regulator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin modification

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Histone acetyltransferase type B subunit 2
PRO_0000227733

Regions

Repeat136 – 17641WD 1
Repeat187 – 22741WD 2
Repeat237 – 27741WD 3
Repeat284 – 32441WD 4
Repeat328 – 36841WD 5
Repeat385 – 42541WD 6

Sequences

Sequence LengthMass (Da)Tools
Q4WEI5 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: C7E7AC9CA61BD6CE

FASTA43648,951
        10         20         30         40         50         60 
MEPYDDAVVE EHEEQEEERT EEKIINEEYK TWKKNAPFLY DMILSTALEW PTLTTQWLPD 

        70         80         90        100        110        120 
KQEVPDKPYS THRLLIGTHT SSDAQNYLQI AHVQLPNPSA PNPDDYDEER GEIGGYGGSS 

       130        140        150        160        170        180 
KKAPMEIKFN IVQKIDHKGE VNKARYQPQN PNIIATMCTD GRVMVWDRSK HPSLPTGQVN 

       190        200        210        220        230        240 
PQMELIGHTK EGFGLSWSPH TAGQLATGSE DKTVRIWDLT TYSKGNKLLK PSRTYTHHSS 

       250        260        270        280        290        300 
IVNDVQYHPL HSSLIGTVSD DITLQILDIR ESETTRAAAS TEGQHRDAIN AIAFNPAAET 

       310        320        330        340        350        360 
VLATGSADKT IGLWDLRNLK TKLHSLESHT DSVTSISWHP FEEAVLASAS YDRKIAFWDL 

       370        380        390        400        410        420 
SRAGEEQTPE DAQDGPPELL FQHGGHTNRI SDFSWNLNDP WVLCSAAEDN LLQVWKVADA 

       430 
IVGKDLEDVP TEELEP

« Hide

References

[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAHF01000011 Genomic DNA. Translation: EAL85992.1.
RefSeqXP_748030.1. XM_742937.1.

3D structure databases

ProteinModelPortalQ4WEI5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4WEI5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00002529; CADAFUAP00002529; CADAFUAG00002529.
GeneID3505380.
GenomeReviewsGene locus hat2 in contig CM000173_GR.
KEGGafm:AFUA_5G03130.

Phylogenomic databases

eggNOGfuNOG07048.
GeneTreeEFGT00050000000073.
HOGENOMHBG435352.
OMAATPKEHR.
OrthoDBEOG412QFD.

Family and domain databases

InterProIPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR011046. WD40_repeat-like_dom.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KOK10752.
PfamPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSPR00320. GPROTEINBRPT.
SMARTSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMSSF50978. WD40_like. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHAT2_ASPFU
AccessionPrimary (citable) accession number: Q4WEI5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2005
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents