Reviewed, UniProtKB/Swiss-Prot Q4WEI5 (HAT2_ASPFU)

Names and origin

Protein names

Recommended name:
    Histone acetyltransferase type B subunit 2
    EC=2.3.1.48

Gene names

Name:	hat2
ORF Names:	AFUA_5G03130

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	436 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subunit structure	Component of the HAT-B complex composed of at least hat1 and hat2. The HAT-B complex binds to histone H4 tail By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 6 WD repeats.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm Nucleus
Domain	Repeat WD repeat
Molecular function	Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 436	436	Histone acetyltransferase type B subunit 2		PRO_0000227733
Regions
	Repeat	136 – 176	41	WD 1
	Repeat	187 – 227	41	WD 2
	Repeat	237 – 277	41	WD 3
	Repeat	284 – 324	41	WD 4
	Repeat	328 – 368	41	WD 5
	Repeat	385 – 425	41	WD 6

Sequences

	Sequence		Length	Mass (Da)
	Q4WEI5-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: C7E7AC9CA61BD6CE	FASTA	436	48,951
	10 20 30 40 50 60 MEPYDDAVVE EHEEQEEERT EEKIINEEYK TWKKNAPFLY DMILSTALEW PTLTTQWLPD 70 80 90 100 110 120 KQEVPDKPYS THRLLIGTHT SSDAQNYLQI AHVQLPNPSA PNPDDYDEER GEIGGYGGSS 130 140 150 160 170 180 KKAPMEIKFN IVQKIDHKGE VNKARYQPQN PNIIATMCTD GRVMVWDRSK HPSLPTGQVN 190 200 210 220 230 240 PQMELIGHTK EGFGLSWSPH TAGQLATGSE DKTVRIWDLT TYSKGNKLLK PSRTYTHHSS 250 260 270 280 290 300 IVNDVQYHPL HSSLIGTVSD DITLQILDIR ESETTRAAAS TEGQHRDAIN AIAFNPAAET 310 320 330 340 350 360 VLATGSADKT IGLWDLRNLK TKLHSLESHT DSVTSISWHP FEEAVLASAS YDRKIAFWDL 370 380 390 400 410 420 SRAGEEQTPE DAQDGPPELL FQHGGHTNRI SDFSWNLNDP WVLCSAAEDN LLQVWKVADA 430 IVGKDLEDVP TEELEP

References

[1]

"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAHF01000011 Genomic DNA. Translation: EAL85992.1.
RefSeq	XP_748030.1.
3D structure databases
SMR	Q4WEI5. Positions 18-423.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4WEI5.
Genome annotation databases
GeneID	3505380.
KEGG	afm:AFUA_5G03130.
Phylogenomic databases
eggNOG	fuNOG07048.
HOGENOM	HBG435352.
OMA	DRRLHVW.
OrthoDB	EOG9QVDVC.
PhylomeDB	Q4WEI5.
Enzyme and pathway databases
BRENDA	2.3.1.48. 18841.
Family and domain databases
InterPro	IPR020472. G-protein_beta_WD-40_rep_reg. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 6 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
SMART	SM00320. WD40. 6 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 3 hits. PS50082. WD_REPEATS_2. 5 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HAT2_ASPFU

Accession

Primary (citable) accession number: Q4WEI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 5, 2005
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)