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Q4WD56

- BGLE_ASPFU

UniProt

Q4WD56 - BGLE_ASPFU

Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei446 – 4461By similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-glucosidase E (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase E
    Cellobiase E
    Gentiobiase E
    Gene namesi
    Name:bglE
    ORF Names:AFUA_6G03570
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 6

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10331033Probable beta-glucosidase EPRO_0000394872Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi593 – 5931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi909 – 9091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi918 – 9181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi976 – 9761N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00000578.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4WD56.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 161161CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 1033851ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei162 – 18221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000031215.
    KOiK05349.
    OMAiGTGWSMG.
    OrthoDBiEOG7HMS8F.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProiIPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR30620. PTHR30620. 1 hit.
    PfamiPF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view]
    PRINTSiPR00133. GLHYDRLASE3.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q4WD56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPDSTHGG SFRDHLKTND RSSTSKGKQR YSPLQEAIPE EISSFRSPSE     50
    YADTDSDSDL ERSGSYKLRP VDRYGSHHSS AFIPVIREEN GVETYLDSIT 100
    EAEQELLSAS KQYDLVDDDD SSDFDSDEEA TLRYRLKDRL KRRRARLQAW 150
    QPVKYARIWW RTLLAVVVTL VVVVWGFLSF AVSHREEPTV WPMVPSDSWF 200
    PSPKGGTLKH WEESYKKAQS LVRNMTLVEK VNITTGIGWQ MGLCVGNTGP 250
    ADIVKFPSLC LQDGPQGLRF ADHVSAFPAG ITTGSTWNRE LMRERGVAMG 300
    REARLKGVNV LLGPSMGPLG MMPAGGRNWE GFGSDPVLQA VAAAETIRGI 350
    QSNGVMATAK HFVMNEQEHF RQPFEWGIPT ALSSNVGDRA LHEVFAWPFA 400
    ESIRADVASV MCSYQMVNNS HACENSKLLN GILKDELGFQ GFVQSDWLAQ 450
    RSGINSALGG LDMSMPGDGL HWVDGKSLWG SELTRAVLNT SVPVERLNDM 500
    VTRIVAAWYH LGQDTWERPP PEGNGGPNFS SWTNDEVGWL HTGSNDGSYA 550
    RVNHYVDAQG TGPEAHSIIA RKVAAEGTVL LKNVDRTLPL SRNASSPSGG 600
    ILRVGIYGDD AGPALGPNAC PDRGCNQGTL ATGWGSGTVE FPYLVSPIEA 650
    LESAWSTEIE STAYLRNAVM PADAVDKDLC LVFVNADSGE GYISAGGIHG 700
    DRNDLFLQKG GDTLVRTVSS NCGGGQGKTV VVIHAVGPVV MESWIDLPGV 750
    HAVLLANLPG QESGNALVDV LFGEVDASGR LPYTIGKSLE DYGPGAQVLY 800
    EPNAPVPQVD FLDALYIDYR HFDRHNITPR FEFGFGLSYT TFELLDLSIS 850
    PLQQKSRSVP PRPADAVAPP VYDISLPDPA SALFPAGFQP VFKYIYPYLS 900
    NLDGTAPHNY SFYPKGYNET QRPSPAGGGA GGHPALYEEM VSVKLQVSNT 950
    GDRKGQEVVQ VYVSFPPDFP ERVLRNFTKI ELEPSERREV QMTLSRKDLS 1000
    YWSTREQNWV MPEGKFQIWV GRSSRDLPLM GEY 1033
    Length:1,033
    Mass (Da):113,423
    Last modified:July 5, 2005 - v1
    Checksum:i68768F797E72DE92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000012 Genomic DNA. Translation: EAL85682.1.
    RefSeqiXP_747720.1. XM_742627.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00000578; CADAFUAP00000578; CADAFUAG00000578.
    GeneIDi3505005.
    KEGGiafm:AFUA_6G03570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000012 Genomic DNA. Translation: EAL85682.1 .
    RefSeqi XP_747720.1. XM_742627.1.

    3D structure databases

    ProteinModelPortali Q4WD56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00000578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00000578 ; CADAFUAP00000578 ; CADAFUAG00000578 .
    GeneIDi 3505005.
    KEGGi afm:AFUA_6G03570.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000031215.
    KOi K05349.
    OMAi GTGWSMG.
    OrthoDBi EOG7HMS8F.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    3.40.50.1700. 1 hit.
    InterProi IPR026891. Fn3-like.
    IPR026892. Glyco_hydro_3.
    IPR002772. Glyco_hydro_3_C.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR30620. PTHR30620. 1 hit.
    Pfami PF14310. Fn3-like. 1 hit.
    PF00933. Glyco_hydro_3. 1 hit.
    PF01915. Glyco_hydro_3_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00133. GLHYDRLASE3.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF52279. SSF52279. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiBGLE_ASPFU
    AccessioniPrimary (citable) accession number: Q4WD56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3