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Q4WD56

- BGLE_ASPFU

UniProt

Q4WD56 - BGLE_ASPFU

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Protein
Probable beta-glucosidase E
Gene
bglE, AFUA_6G03570
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei446 – 4461 By similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase E (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene namesi
Name:bglE
ORF Names:AFUA_6G03570
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 6

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 161161Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei162 – 18221Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini183 – 1033851Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10331033Probable beta-glucosidase E
PRO_0000394872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi224 – 2241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi232 – 2321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi489 – 4891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi528 – 5281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi593 – 5931N-linked (GlcNAc...) Reviewed prediction
Glycosylationi909 – 9091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi918 – 9181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi976 – 9761N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00000578.

Structurei

3D structure databases

ProteinModelPortaliQ4WD56.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1472.
HOGENOMiHOG000031215.
KOiK05349.
OMAiGTGWSMG.
OrthoDBiEOG7HMS8F.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProiIPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR30620. PTHR30620. 1 hit.
PfamiPF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view]
PRINTSiPR00133. GLHYDRLASE3.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.

Sequencei

Sequence statusi: Complete.

Q4WD56-1 [UniParc]FASTAAdd to Basket

« Hide

MAPPDSTHGG SFRDHLKTND RSSTSKGKQR YSPLQEAIPE EISSFRSPSE     50
YADTDSDSDL ERSGSYKLRP VDRYGSHHSS AFIPVIREEN GVETYLDSIT 100
EAEQELLSAS KQYDLVDDDD SSDFDSDEEA TLRYRLKDRL KRRRARLQAW 150
QPVKYARIWW RTLLAVVVTL VVVVWGFLSF AVSHREEPTV WPMVPSDSWF 200
PSPKGGTLKH WEESYKKAQS LVRNMTLVEK VNITTGIGWQ MGLCVGNTGP 250
ADIVKFPSLC LQDGPQGLRF ADHVSAFPAG ITTGSTWNRE LMRERGVAMG 300
REARLKGVNV LLGPSMGPLG MMPAGGRNWE GFGSDPVLQA VAAAETIRGI 350
QSNGVMATAK HFVMNEQEHF RQPFEWGIPT ALSSNVGDRA LHEVFAWPFA 400
ESIRADVASV MCSYQMVNNS HACENSKLLN GILKDELGFQ GFVQSDWLAQ 450
RSGINSALGG LDMSMPGDGL HWVDGKSLWG SELTRAVLNT SVPVERLNDM 500
VTRIVAAWYH LGQDTWERPP PEGNGGPNFS SWTNDEVGWL HTGSNDGSYA 550
RVNHYVDAQG TGPEAHSIIA RKVAAEGTVL LKNVDRTLPL SRNASSPSGG 600
ILRVGIYGDD AGPALGPNAC PDRGCNQGTL ATGWGSGTVE FPYLVSPIEA 650
LESAWSTEIE STAYLRNAVM PADAVDKDLC LVFVNADSGE GYISAGGIHG 700
DRNDLFLQKG GDTLVRTVSS NCGGGQGKTV VVIHAVGPVV MESWIDLPGV 750
HAVLLANLPG QESGNALVDV LFGEVDASGR LPYTIGKSLE DYGPGAQVLY 800
EPNAPVPQVD FLDALYIDYR HFDRHNITPR FEFGFGLSYT TFELLDLSIS 850
PLQQKSRSVP PRPADAVAPP VYDISLPDPA SALFPAGFQP VFKYIYPYLS 900
NLDGTAPHNY SFYPKGYNET QRPSPAGGGA GGHPALYEEM VSVKLQVSNT 950
GDRKGQEVVQ VYVSFPPDFP ERVLRNFTKI ELEPSERREV QMTLSRKDLS 1000
YWSTREQNWV MPEGKFQIWV GRSSRDLPLM GEY 1033
Length:1,033
Mass (Da):113,423
Last modified:July 5, 2005 - v1
Checksum:i68768F797E72DE92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000012 Genomic DNA. Translation: EAL85682.1.
RefSeqiXP_747720.1. XM_742627.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00000578; CADAFUAP00000578; CADAFUAG00000578.
GeneIDi3505005.
KEGGiafm:AFUA_6G03570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000012 Genomic DNA. Translation: EAL85682.1 .
RefSeqi XP_747720.1. XM_742627.1.

3D structure databases

ProteinModelPortali Q4WD56.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00000578.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00000578 ; CADAFUAP00000578 ; CADAFUAG00000578 .
GeneIDi 3505005.
KEGGi afm:AFUA_6G03570.

Phylogenomic databases

eggNOGi COG1472.
HOGENOMi HOG000031215.
KOi K05349.
OMAi GTGWSMG.
OrthoDBi EOG7HMS8F.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.300. 1 hit.
3.40.50.1700. 1 hit.
InterProi IPR026891. Fn3-like.
IPR026892. Glyco_hydro_3.
IPR002772. Glyco_hydro_3_C.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR30620. PTHR30620. 1 hit.
Pfami PF14310. Fn3-like. 1 hit.
PF00933. Glyco_hydro_3. 1 hit.
PF01915. Glyco_hydro_3_C. 1 hit.
[Graphical view ]
PRINTSi PR00133. GLHYDRLASE3.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52279. SSF52279. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiBGLE_ASPFU
AccessioniPrimary (citable) accession number: Q4WD56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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