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Protein

Probable beta-glucosidase E

Gene

bglE

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei446By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase E (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase E
Cellobiase E
Gentiobiase E
Gene namesi
Name:bglE
ORF Names:AFUA_6G03570
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu6g03570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 161CytoplasmicSequence analysisAdd BLAST161
Transmembranei162 – 182Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini183 – 1033ExtracellularSequence analysisAdd BLAST851

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003948721 – 1033Probable beta-glucosidase EAdd BLAST1033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi528N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi909N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi918N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi976N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00009206

Structurei

3D structure databases

ProteinModelPortaliQ4WD56
SMRiQ4WD56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000031215
InParanoidiQ4WD56
KOiK05349
OMAiCSYQMVN
OrthoDBiEOG092C0ZJY

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.20.20.300, 1 hit
3.40.50.1700, 1 hit
InterProiView protein in InterPro
IPR026891 Fn3-like
IPR002772 Glyco_hydro_3_C
IPR036881 Glyco_hydro_3_C_sf
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF14310 Fn3-like, 1 hit
PF00933 Glyco_hydro_3, 1 hit
PF01915 Glyco_hydro_3_C, 1 hit
PRINTSiPR00133 GLHYDRLASE3
SMARTiView protein in SMART
SM01217 Fn3_like, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF52279 SSF52279, 2 hits

Sequencei

Sequence statusi: Complete.

Q4WD56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPDSTHGG SFRDHLKTND RSSTSKGKQR YSPLQEAIPE EISSFRSPSE
60 70 80 90 100
YADTDSDSDL ERSGSYKLRP VDRYGSHHSS AFIPVIREEN GVETYLDSIT
110 120 130 140 150
EAEQELLSAS KQYDLVDDDD SSDFDSDEEA TLRYRLKDRL KRRRARLQAW
160 170 180 190 200
QPVKYARIWW RTLLAVVVTL VVVVWGFLSF AVSHREEPTV WPMVPSDSWF
210 220 230 240 250
PSPKGGTLKH WEESYKKAQS LVRNMTLVEK VNITTGIGWQ MGLCVGNTGP
260 270 280 290 300
ADIVKFPSLC LQDGPQGLRF ADHVSAFPAG ITTGSTWNRE LMRERGVAMG
310 320 330 340 350
REARLKGVNV LLGPSMGPLG MMPAGGRNWE GFGSDPVLQA VAAAETIRGI
360 370 380 390 400
QSNGVMATAK HFVMNEQEHF RQPFEWGIPT ALSSNVGDRA LHEVFAWPFA
410 420 430 440 450
ESIRADVASV MCSYQMVNNS HACENSKLLN GILKDELGFQ GFVQSDWLAQ
460 470 480 490 500
RSGINSALGG LDMSMPGDGL HWVDGKSLWG SELTRAVLNT SVPVERLNDM
510 520 530 540 550
VTRIVAAWYH LGQDTWERPP PEGNGGPNFS SWTNDEVGWL HTGSNDGSYA
560 570 580 590 600
RVNHYVDAQG TGPEAHSIIA RKVAAEGTVL LKNVDRTLPL SRNASSPSGG
610 620 630 640 650
ILRVGIYGDD AGPALGPNAC PDRGCNQGTL ATGWGSGTVE FPYLVSPIEA
660 670 680 690 700
LESAWSTEIE STAYLRNAVM PADAVDKDLC LVFVNADSGE GYISAGGIHG
710 720 730 740 750
DRNDLFLQKG GDTLVRTVSS NCGGGQGKTV VVIHAVGPVV MESWIDLPGV
760 770 780 790 800
HAVLLANLPG QESGNALVDV LFGEVDASGR LPYTIGKSLE DYGPGAQVLY
810 820 830 840 850
EPNAPVPQVD FLDALYIDYR HFDRHNITPR FEFGFGLSYT TFELLDLSIS
860 870 880 890 900
PLQQKSRSVP PRPADAVAPP VYDISLPDPA SALFPAGFQP VFKYIYPYLS
910 920 930 940 950
NLDGTAPHNY SFYPKGYNET QRPSPAGGGA GGHPALYEEM VSVKLQVSNT
960 970 980 990 1000
GDRKGQEVVQ VYVSFPPDFP ERVLRNFTKI ELEPSERREV QMTLSRKDLS
1010 1020 1030
YWSTREQNWV MPEGKFQIWV GRSSRDLPLM GEY
Length:1,033
Mass (Da):113,423
Last modified:July 5, 2005 - v1
Checksum:i68768F797E72DE92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000012 Genomic DNA Translation: EAL85682.1
RefSeqiXP_747720.1, XM_742627.1

Genome annotation databases

EnsemblFungiiCADAFUAT00000578; CADAFUAP00000578; CADAFUAG00000578
GeneIDi3505005
KEGGiafm:AFUA_6G03570

Similar proteinsi

Entry informationi

Entry nameiBGLE_ASPFU
AccessioniPrimary (citable) accession number: Q4WD56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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