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Q4WCZ8

- PGLRX_ASPFU

UniProt

Q4WCZ8 - PGLRX_ASPFU

Protein

Probable exopolygalacturonase X

Gene

pgaX

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 2 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.By similarity

    Catalytic activityi

    ((1->4)-alpha-D-galacturonide)(n) + H2O = ((1->4)-alpha-D-galacturonide)(n-1) + D-galacturonate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei245 – 2451Proton donorPROSITE-ProRule annotation
    Active sitei268 – 2681PROSITE-ProRule annotation

    GO - Molecular functioni

    1. galacturan 1,4-alpha-galacturonidase activity Source: UniProtKB-EC
    2. polygalacturonase activity Source: UniProtKB

    GO - Biological processi

    1. pectin catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell wall biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable exopolygalacturonase X (EC:3.2.1.67)
    Short name:
    ExoPG
    Alternative name(s):
    Galacturan 1,4-alpha-galacturonidase
    Poly(1,4-alpha-D-galacturonide)galacturonohydrolase
    Gene namesi
    Name:pgaX
    ORF Names:AFUA_6G02980
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 6

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 432409Probable exopolygalacturonase XPRO_0000393668Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi247 ↔ 264By similarity
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi392 ↔ 398By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati231 – 25222PbH1 1Add
    BLAST
    Repeati254 – 27421PbH1 2Add
    BLAST
    Repeati285 – 30622PbH1 3Add
    BLAST
    Repeati327 – 34822PbH1 4Add
    BLAST
    Repeati362 – 39433PbH1 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 28 family.Curated
    Contains 5 PbH1 repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG297100.
    HOGENOMiHOG000217379.
    KOiK01238.
    OrthoDBiEOG7R83B4.

    Family and domain databases

    Gene3Di2.160.20.10. 1 hit.
    InterProiIPR000743. Glyco_hydro_28.
    IPR006626. PbH1.
    IPR012334. Pectin_lyas_fold.
    IPR011050. Pectin_lyase_fold/virulence.
    [Graphical view]
    PfamiPF00295. Glyco_hydro_28. 1 hit.
    [Graphical view]
    SMARTiSM00710. PbH1. 5 hits.
    [Graphical view]
    SUPFAMiSSF51126. SSF51126. 1 hit.
    PROSITEiPS00502. POLYGALACTURONASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4WCZ8-1 [UniParc]FASTAAdd to Basket

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    MKFSYSFVQV VTLLLSLSPS VEGFTRSRND ACKPNHPFRP LPPSQPRTKT    50
    CHVVSNGHGK DDSKNIMKAL HKCNNGGKVV FDANKVYTVG TALDMTFLKH 100
    IDLEVLGKIQ FTNDTDYWQA NSFKHGFQNA TTFFQLGGED VNVYGGGTLD 150
    GNGQVWYDLY AEDALILRPI LFGVIGLKGG TIGPLKLRYS PQWYQLVANS 200
    SDVIFDGIDI SGYSSSKNEA KNTDGWDTYR SDNIVIQNSV INNGDDCVSF 250
    KPNSTNILVQ NLHCNGSHGI SVGSLGQYKG EVDIVQNVLV YNISMYNASD 300
    GARIKVWPGV SSAMSEDLQG GGGLGSVKNV TYNQMYIENV DWAIEVTQCY 350
    GQKNLTLCNE YPSNLTISDI HFKNFRGTTS GKRDPNVGTI VCSSPNVCSD 400
    IYAENIDVKS PKGTDNFVCT NVDKSLLDVN CA 432
    Length:432
    Mass (Da):47,311
    Last modified:April 20, 2010 - v2
    Checksum:i09F95B72D6015B72
    GO

    Sequence cautioni

    The sequence EAL85740.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000012 Genomic DNA. Translation: EAL85740.1. Sequence problems.
    RefSeqiXP_747778.1. XM_742685.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00000417; CADAFUAP00000417; CADAFUAG00000417.
    GeneIDi3505169.
    KEGGiafm:AFUA_6G02980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000012 Genomic DNA. Translation: EAL85740.1 . Sequence problems.
    RefSeqi XP_747778.1. XM_742685.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00000417 ; CADAFUAP00000417 ; CADAFUAG00000417 .
    GeneIDi 3505169.
    KEGGi afm:AFUA_6G02980.

    Phylogenomic databases

    eggNOGi NOG297100.
    HOGENOMi HOG000217379.
    KOi K01238.
    OrthoDBi EOG7R83B4.

    Family and domain databases

    Gene3Di 2.160.20.10. 1 hit.
    InterProi IPR000743. Glyco_hydro_28.
    IPR006626. PbH1.
    IPR012334. Pectin_lyas_fold.
    IPR011050. Pectin_lyase_fold/virulence.
    [Graphical view ]
    Pfami PF00295. Glyco_hydro_28. 1 hit.
    [Graphical view ]
    SMARTi SM00710. PbH1. 5 hits.
    [Graphical view ]
    SUPFAMi SSF51126. SSF51126. 1 hit.
    PROSITEi PS00502. POLYGALACTURONASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiPGLRX_ASPFU
    AccessioniPrimary (citable) accession number: Q4WCZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 57 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3