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Q4WCZ8

- PGLRX_ASPFU

UniProt

Q4WCZ8 - PGLRX_ASPFU

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Protein
Probable exopolygalacturonase X
Gene
pgaX, AFUA_6G02980
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates By similarity.

Catalytic activityi

((1->4)-alpha-D-galacturonide)(n) + H2O = ((1->4)-alpha-D-galacturonide)(n-1) + D-galacturonate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei245 – 2451Proton donor By similarity
Active sitei268 – 2681 By similarity

GO - Molecular functioni

  1. galacturan 1,4-alpha-galacturonidase activity Source: UniProtKB-EC
  2. polygalacturonase activity Source: UniProtKB

GO - Biological processi

  1. pectin catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable exopolygalacturonase X (EC:3.2.1.67)
Short name:
ExoPG
Alternative name(s):
Galacturan 1,4-alpha-galacturonidase
Poly(1,4-alpha-D-galacturonide)galacturonohydrolase
Gene namesi
Name:pgaX
ORF Names:AFUA_6G02980
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 6

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 432409Probable exopolygalacturonase X
PRO_0000393668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi129 – 1291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi247 ↔ 264 By similarity
Glycosylationi253 – 2531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi292 – 2921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi329 – 3291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi354 – 3541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi364 – 3641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi392 ↔ 398 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati231 – 25222PbH1 1
Add
BLAST
Repeati254 – 27421PbH1 2
Add
BLAST
Repeati285 – 30622PbH1 3
Add
BLAST
Repeati327 – 34822PbH1 4
Add
BLAST
Repeati362 – 39433PbH1 5
Add
BLAST

Sequence similaritiesi

Contains 5 PbH1 repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG297100.
HOGENOMiHOG000217379.
KOiK01238.
OrthoDBiEOG7R83B4.

Family and domain databases

Gene3Di2.160.20.10. 1 hit.
InterProiIPR000743. Glyco_hydro_28.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view]
PfamiPF00295. Glyco_hydro_28. 1 hit.
[Graphical view]
SMARTiSM00710. PbH1. 5 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 1 hit.
PROSITEiPS00502. POLYGALACTURONASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WCZ8-1 [UniParc]FASTAAdd to Basket

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MKFSYSFVQV VTLLLSLSPS VEGFTRSRND ACKPNHPFRP LPPSQPRTKT    50
CHVVSNGHGK DDSKNIMKAL HKCNNGGKVV FDANKVYTVG TALDMTFLKH 100
IDLEVLGKIQ FTNDTDYWQA NSFKHGFQNA TTFFQLGGED VNVYGGGTLD 150
GNGQVWYDLY AEDALILRPI LFGVIGLKGG TIGPLKLRYS PQWYQLVANS 200
SDVIFDGIDI SGYSSSKNEA KNTDGWDTYR SDNIVIQNSV INNGDDCVSF 250
KPNSTNILVQ NLHCNGSHGI SVGSLGQYKG EVDIVQNVLV YNISMYNASD 300
GARIKVWPGV SSAMSEDLQG GGGLGSVKNV TYNQMYIENV DWAIEVTQCY 350
GQKNLTLCNE YPSNLTISDI HFKNFRGTTS GKRDPNVGTI VCSSPNVCSD 400
IYAENIDVKS PKGTDNFVCT NVDKSLLDVN CA 432
Length:432
Mass (Da):47,311
Last modified:April 20, 2010 - v2
Checksum:i09F95B72D6015B72
GO

Sequence cautioni

The sequence EAL85740.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000012 Genomic DNA. Translation: EAL85740.1. Sequence problems.
RefSeqiXP_747778.1. XM_742685.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00000417; CADAFUAP00000417; CADAFUAG00000417.
GeneIDi3505169.
KEGGiafm:AFUA_6G02980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000012 Genomic DNA. Translation: EAL85740.1 . Sequence problems.
RefSeqi XP_747778.1. XM_742685.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00000417 ; CADAFUAP00000417 ; CADAFUAG00000417 .
GeneIDi 3505169.
KEGGi afm:AFUA_6G02980.

Phylogenomic databases

eggNOGi NOG297100.
HOGENOMi HOG000217379.
KOi K01238.
OrthoDBi EOG7R83B4.

Family and domain databases

Gene3Di 2.160.20.10. 1 hit.
InterProi IPR000743. Glyco_hydro_28.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
[Graphical view ]
Pfami PF00295. Glyco_hydro_28. 1 hit.
[Graphical view ]
SMARTi SM00710. PbH1. 5 hits.
[Graphical view ]
SUPFAMi SSF51126. SSF51126. 1 hit.
PROSITEi PS00502. POLYGALACTURONASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiPGLRX_ASPFU
AccessioniPrimary (citable) accession number: Q4WCZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 13, 2013
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi