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Q4WCG2 (OS9_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein OS-9 homolog
Gene names
Name:yos9
ORF Names:AFUA_8G04530
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus ›

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.

Subunit structure

Interacts with missfolded ER lumenal proteins By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side By similarity.

Sequence similarities

Belongs to the OS-9 family.

Contains 1 PRKCSH domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   DomainSignal
   LigandLectin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 520497Protein OS-9 homolog
PRO_0000043266

Regions

Domain161 – 23474PRKCSH
Motif517 – 5204Prevents secretion from ER Potential

Sites

Binding site1831Carbohydrate By similarity
Binding site2571Carbohydrate By similarity
Binding site2631Carbohydrate By similarity
Binding site2841Carbohydrate By similarity
Binding site2901Carbohydrate By similarity

Amino acid modifications

Disulfide bond163 ↔ 176 By similarity
Disulfide bond256 ↔ 288 By similarity
Disulfide bond271 ↔ 300 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4WCG2 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: CAD972BBB859CF98

FASTA52058,265
        10         20         30         40         50         60 
MIRRIRTLTP LLVLACAGSG AWASKKAFNI QDDLLAYPQF QVFFPDEYIL DARARELLQN 

        70         80         90        100        110        120 
QQESSSASAD KTFSEGNDAQ VYLGSRKDQS EDVNKETIEG SGFTYEEMLL EGQRYLCSIP 

       130        140        150        160        170        180 
QVDNGNRDQT NGAESTSKED EQREIARATD RGLELLREME GKCMYYISGW WSYSFCYKKQ 

       190        200        210        220        230        240 
IKQFHALPSG PGVPNYPPIE DSTTHSFVLG RFPNSGDDED LEGDAEHKKT TTDVAELQTK 

       250        260        270        280        290        300 
GGSRYLVQRL GGGTKCDLTG KDRKIEVQFH CHPQSTDRIG WIKELTTCSY LMVIYTPRLC 

       310        320        330        340        350        360 
NDVAFLPPQQ DEAHAIECRE ILSEEEVSDW EANREYHLAQ QLVESAITPE FPVVGDIEVG 

       370        380        390        400        410        420 
AHKWVGSEGK QIEKGRVASI GEEKIEVVAK RQNGEITRLS KEELKKYGLD PEKIETLKSR 

       430        440        450        460        470        480 
LEELAKGKDW TLEIVESNGE RGLVGTVDSN DDEKEDHAAQ GSISQPAQGT TADKGESNAE 

       490        500        510        520 
TGEEKKKADE KIDHYEPEKS GPTTDDADDG SEEIFFKDEL

« Hide

References

[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAHF01000013 Genomic DNA. Translation: EAL85222.1.
RefSeqXP_747260.1. XM_742167.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING5085.CADAFUAP00003023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00003023; CADAFUAP00003023; CADAFUAG00003023.
GeneID3504663.
KEGGafm:AFUA_8G04530.

Phylogenomic databases

eggNOGNOG309879.
HOGENOMHOG000157538.
KOK10088.
OMASGWWSYS.
OrthoDBEOG4PCF2J.

Family and domain databases

InterProIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMSSF50911. Man6php_recept. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOS9_ASPFU
AccessionPrimary (citable) accession number: Q4WCG2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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