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Protein

Protein OS-9 homolog

Gene

yos9

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831CarbohydrateBy similarity
Binding sitei257 – 2571CarbohydrateBy similarity
Binding sitei263 – 2631CarbohydrateBy similarity
Binding sitei284 – 2841CarbohydrateBy similarity
Binding sitei290 – 2901CarbohydrateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:yos9
ORF Names:AFUA_8G04530
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiFungiDB:Afu8g04530.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 520497Protein OS-9 homologPRO_0000043266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi163 ↔ 176By similarity
Disulfide bondi256 ↔ 288By similarity
Disulfide bondi271 ↔ 300By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUAP00003023.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 23474PRKCSHAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi517 – 5204Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the OS-9 family.Curated
Contains 1 PRKCSH domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG309879.
HOGENOMiHOG000157538.
InParanoidiQ4WCG2.
KOiK10088.
OMAiLCDDVAF.
OrthoDBiEOG7R2BVR.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WCG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRRIRTLTP LLVLACAGSG AWASKKAFNI QDDLLAYPQF QVFFPDEYIL
60 70 80 90 100
DARARELLQN QQESSSASAD KTFSEGNDAQ VYLGSRKDQS EDVNKETIEG
110 120 130 140 150
SGFTYEEMLL EGQRYLCSIP QVDNGNRDQT NGAESTSKED EQREIARATD
160 170 180 190 200
RGLELLREME GKCMYYISGW WSYSFCYKKQ IKQFHALPSG PGVPNYPPIE
210 220 230 240 250
DSTTHSFVLG RFPNSGDDED LEGDAEHKKT TTDVAELQTK GGSRYLVQRL
260 270 280 290 300
GGGTKCDLTG KDRKIEVQFH CHPQSTDRIG WIKELTTCSY LMVIYTPRLC
310 320 330 340 350
NDVAFLPPQQ DEAHAIECRE ILSEEEVSDW EANREYHLAQ QLVESAITPE
360 370 380 390 400
FPVVGDIEVG AHKWVGSEGK QIEKGRVASI GEEKIEVVAK RQNGEITRLS
410 420 430 440 450
KEELKKYGLD PEKIETLKSR LEELAKGKDW TLEIVESNGE RGLVGTVDSN
460 470 480 490 500
DDEKEDHAAQ GSISQPAQGT TADKGESNAE TGEEKKKADE KIDHYEPEKS
510 520
GPTTDDADDG SEEIFFKDEL
Length:520
Mass (Da):58,265
Last modified:July 5, 2005 - v1
Checksum:iCAD972BBB859CF98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000013 Genomic DNA. Translation: EAL85222.1.
RefSeqiXP_747260.1. XM_742167.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00003023; CADAFUAP00003023; CADAFUAG00003023.
GeneIDi3504663.
KEGGiafm:AFUA_8G04530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000013 Genomic DNA. Translation: EAL85222.1.
RefSeqiXP_747260.1. XM_742167.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUAP00003023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADAFUAT00003023; CADAFUAP00003023; CADAFUAG00003023.
GeneIDi3504663.
KEGGiafm:AFUA_8G04530.

Organism-specific databases

EuPathDBiFungiDB:Afu8g04530.

Phylogenomic databases

eggNOGiNOG309879.
HOGENOMiHOG000157538.
InParanoidiQ4WCG2.
KOiK10088.
OMAiLCDDVAF.
OrthoDBiEOG7R2BVR.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiOS9_ASPFU
AccessioniPrimary (citable) accession number: Q4WCG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: April 29, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.