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Q4WCG2

- OS9_ASPFU

UniProt

Q4WCG2 - OS9_ASPFU

Protein

Protein OS-9 homolog

Gene

yos9

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei183 – 1831CarbohydrateBy similarity
    Binding sitei257 – 2571CarbohydrateBy similarity
    Binding sitei263 – 2631CarbohydrateBy similarity
    Binding sitei284 – 2841CarbohydrateBy similarity
    Binding sitei290 – 2901CarbohydrateBy similarity

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein OS-9 homolog
    Gene namesi
    Name:yos9
    ORF Names:AFUA_8G04530
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 8

    Subcellular locationi

    Endoplasmic reticulum membrane PROSITE-ProRule annotation; Peripheral membrane protein By similarity; Lumenal side By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 520497Protein OS-9 homologPRO_0000043266Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi163 ↔ 176By similarity
    Disulfide bondi256 ↔ 288By similarity
    Disulfide bondi271 ↔ 300By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Interacts with missfolded ER lumenal proteins.By similarity

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00003023.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini161 – 23474PRKCSHAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi517 – 5204Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the OS-9 family.Curated
    Contains 1 PRKCSH domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG309879.
    HOGENOMiHOG000157538.
    KOiK10088.
    OMAiLCDDVAF.
    OrthoDBiEOG7R2BVR.

    Family and domain databases

    Gene3Di2.70.130.10. 1 hit.
    InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
    IPR012913. PRKCSH.
    [Graphical view]
    PfamiPF07915. PRKCSH. 1 hit.
    [Graphical view]
    SUPFAMiSSF50911. SSF50911. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4WCG2-1 [UniParc]FASTAAdd to Basket

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    MIRRIRTLTP LLVLACAGSG AWASKKAFNI QDDLLAYPQF QVFFPDEYIL    50
    DARARELLQN QQESSSASAD KTFSEGNDAQ VYLGSRKDQS EDVNKETIEG 100
    SGFTYEEMLL EGQRYLCSIP QVDNGNRDQT NGAESTSKED EQREIARATD 150
    RGLELLREME GKCMYYISGW WSYSFCYKKQ IKQFHALPSG PGVPNYPPIE 200
    DSTTHSFVLG RFPNSGDDED LEGDAEHKKT TTDVAELQTK GGSRYLVQRL 250
    GGGTKCDLTG KDRKIEVQFH CHPQSTDRIG WIKELTTCSY LMVIYTPRLC 300
    NDVAFLPPQQ DEAHAIECRE ILSEEEVSDW EANREYHLAQ QLVESAITPE 350
    FPVVGDIEVG AHKWVGSEGK QIEKGRVASI GEEKIEVVAK RQNGEITRLS 400
    KEELKKYGLD PEKIETLKSR LEELAKGKDW TLEIVESNGE RGLVGTVDSN 450
    DDEKEDHAAQ GSISQPAQGT TADKGESNAE TGEEKKKADE KIDHYEPEKS 500
    GPTTDDADDG SEEIFFKDEL 520
    Length:520
    Mass (Da):58,265
    Last modified:July 5, 2005 - v1
    Checksum:iCAD972BBB859CF98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000013 Genomic DNA. Translation: EAL85222.1.
    RefSeqiXP_747260.1. XM_742167.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00003023; CADAFUAP00003023; CADAFUAG00003023.
    GeneIDi3504663.
    KEGGiafm:AFUA_8G04530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000013 Genomic DNA. Translation: EAL85222.1 .
    RefSeqi XP_747260.1. XM_742167.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00003023.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00003023 ; CADAFUAP00003023 ; CADAFUAG00003023 .
    GeneIDi 3504663.
    KEGGi afm:AFUA_8G04530.

    Phylogenomic databases

    eggNOGi NOG309879.
    HOGENOMi HOG000157538.
    KOi K10088.
    OMAi LCDDVAF.
    OrthoDBi EOG7R2BVR.

    Family and domain databases

    Gene3Di 2.70.130.10. 1 hit.
    InterProi IPR009011. Man6P_isomerase_rcpt-bd_dom.
    IPR012913. PRKCSH.
    [Graphical view ]
    Pfami PF07915. PRKCSH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50911. SSF50911. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiOS9_ASPFU
    AccessioniPrimary (citable) accession number: Q4WCG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3