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Q4WCG2

- OS9_ASPFU

UniProt

Q4WCG2 - OS9_ASPFU

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Protein
Protein OS-9 homolog
Gene
yos9, AFUA_8G04530
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831Carbohydrate By similarity
Binding sitei257 – 2571Carbohydrate By similarity
Binding sitei263 – 2631Carbohydrate By similarity
Binding sitei284 – 2841Carbohydrate By similarity
Binding sitei290 – 2901Carbohydrate By similarity

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:yos9
ORF Names:AFUA_8G04530
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 8

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 520497Protein OS-9 homolog
PRO_0000043266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi163 ↔ 176 By similarity
Disulfide bondi256 ↔ 288 By similarity
Disulfide bondi271 ↔ 300 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins By similarity.

Protein-protein interaction databases

STRINGi5085.CADAFUAP00003023.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 23474PRKCSH
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi517 – 5204Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the OS-9 family.
Contains 1 PRKCSH domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG309879.
HOGENOMiHOG000157538.
KOiK10088.
OMAiLCDDVAF.
OrthoDBiEOG7R2BVR.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WCG2-1 [UniParc]FASTAAdd to Basket

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MIRRIRTLTP LLVLACAGSG AWASKKAFNI QDDLLAYPQF QVFFPDEYIL    50
DARARELLQN QQESSSASAD KTFSEGNDAQ VYLGSRKDQS EDVNKETIEG 100
SGFTYEEMLL EGQRYLCSIP QVDNGNRDQT NGAESTSKED EQREIARATD 150
RGLELLREME GKCMYYISGW WSYSFCYKKQ IKQFHALPSG PGVPNYPPIE 200
DSTTHSFVLG RFPNSGDDED LEGDAEHKKT TTDVAELQTK GGSRYLVQRL 250
GGGTKCDLTG KDRKIEVQFH CHPQSTDRIG WIKELTTCSY LMVIYTPRLC 300
NDVAFLPPQQ DEAHAIECRE ILSEEEVSDW EANREYHLAQ QLVESAITPE 350
FPVVGDIEVG AHKWVGSEGK QIEKGRVASI GEEKIEVVAK RQNGEITRLS 400
KEELKKYGLD PEKIETLKSR LEELAKGKDW TLEIVESNGE RGLVGTVDSN 450
DDEKEDHAAQ GSISQPAQGT TADKGESNAE TGEEKKKADE KIDHYEPEKS 500
GPTTDDADDG SEEIFFKDEL 520
Length:520
Mass (Da):58,265
Last modified:July 5, 2005 - v1
Checksum:iCAD972BBB859CF98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000013 Genomic DNA. Translation: EAL85222.1.
RefSeqiXP_747260.1. XM_742167.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00003023; CADAFUAP00003023; CADAFUAG00003023.
GeneIDi3504663.
KEGGiafm:AFUA_8G04530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000013 Genomic DNA. Translation: EAL85222.1 .
RefSeqi XP_747260.1. XM_742167.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00003023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00003023 ; CADAFUAP00003023 ; CADAFUAG00003023 .
GeneIDi 3504663.
KEGGi afm:AFUA_8G04530.

Phylogenomic databases

eggNOGi NOG309879.
HOGENOMi HOG000157538.
KOi K10088.
OMAi LCDDVAF.
OrthoDBi EOG7R2BVR.

Family and domain databases

Gene3Di 2.70.130.10. 1 hit.
InterProi IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view ]
Pfami PF07915. PRKCSH. 1 hit.
[Graphical view ]
SUPFAMi SSF50911. SSF50911. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiOS9_ASPFU
AccessioniPrimary (citable) accession number: Q4WCG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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