Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein OS-9 homolog

Gene

yos9

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei183CarbohydrateBy similarity1
Binding sitei257CarbohydrateBy similarity1
Binding sitei263CarbohydrateBy similarity1
Binding sitei284CarbohydrateBy similarity1
Binding sitei290CarbohydrateBy similarity1

GO - Molecular functioni

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:yos9
ORF Names:AFUA_8G04530
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 8, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu8g04530

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004326624 – 520Protein OS-9 homologAdd BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi163 ↔ 176By similarity
Disulfide bondi256 ↔ 288By similarity
Disulfide bondi271 ↔ 300By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ4WCG2

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUBP00008079

Structurei

3D structure databases

SMRiQ4WCG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 234PRKCSHAdd BLAST74

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi517 – 520Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the OS-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000157538
InParanoidiQ4WCG2
KOiK10088
OMAiVQFHALP
OrthoDBiEOG092C4FPG

Family and domain databases

Gene3Di2.70.130.10, 1 hit
InterProiView protein in InterPro
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
IPR012913 OS9-like
PfamiView protein in Pfam
PF07915 PRKCSH, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WCG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRRIRTLTP LLVLACAGSG AWASKKAFNI QDDLLAYPQF QVFFPDEYIL
60 70 80 90 100
DARARELLQN QQESSSASAD KTFSEGNDAQ VYLGSRKDQS EDVNKETIEG
110 120 130 140 150
SGFTYEEMLL EGQRYLCSIP QVDNGNRDQT NGAESTSKED EQREIARATD
160 170 180 190 200
RGLELLREME GKCMYYISGW WSYSFCYKKQ IKQFHALPSG PGVPNYPPIE
210 220 230 240 250
DSTTHSFVLG RFPNSGDDED LEGDAEHKKT TTDVAELQTK GGSRYLVQRL
260 270 280 290 300
GGGTKCDLTG KDRKIEVQFH CHPQSTDRIG WIKELTTCSY LMVIYTPRLC
310 320 330 340 350
NDVAFLPPQQ DEAHAIECRE ILSEEEVSDW EANREYHLAQ QLVESAITPE
360 370 380 390 400
FPVVGDIEVG AHKWVGSEGK QIEKGRVASI GEEKIEVVAK RQNGEITRLS
410 420 430 440 450
KEELKKYGLD PEKIETLKSR LEELAKGKDW TLEIVESNGE RGLVGTVDSN
460 470 480 490 500
DDEKEDHAAQ GSISQPAQGT TADKGESNAE TGEEKKKADE KIDHYEPEKS
510 520
GPTTDDADDG SEEIFFKDEL
Length:520
Mass (Da):58,265
Last modified:July 5, 2005 - v1
Checksum:iCAD972BBB859CF98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000013 Genomic DNA Translation: EAL85222.1
RefSeqiXP_747260.1, XM_742167.1

Genome annotation databases

EnsemblFungiiCADAFUAT00003023; CADAFUAP00003023; CADAFUAG00003023
GeneIDi3504663
KEGGiafm:AFUA_8G04530

Similar proteinsi

Entry informationi

Entry nameiOS9_ASPFU
AccessioniPrimary (citable) accession number: Q4WCG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health