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Q4WCG2

- OS9_ASPFU

UniProt

Q4WCG2 - OS9_ASPFU

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Protein

Protein OS-9 homolog

Gene

yos9

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831CarbohydrateBy similarity
Binding sitei257 – 2571CarbohydrateBy similarity
Binding sitei263 – 2631CarbohydrateBy similarity
Binding sitei284 – 2841CarbohydrateBy similarity
Binding sitei290 – 2901CarbohydrateBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:yos9
ORF Names:AFUA_8G04530
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 8

Subcellular locationi

Endoplasmic reticulum membrane PROSITE-ProRule annotation; Peripheral membrane protein By similarity; Lumenal side By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 520497Protein OS-9 homologPRO_0000043266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi163 ↔ 176By similarity
Disulfide bondi256 ↔ 288By similarity
Disulfide bondi271 ↔ 300By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins.By similarity

Protein-protein interaction databases

STRINGi5085.CADAFUAP00003023.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 23474PRKCSHAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi517 – 5204Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the OS-9 family.Curated
Contains 1 PRKCSH domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG309879.
HOGENOMiHOG000157538.
InParanoidiQ4WCG2.
KOiK10088.
OMAiLCDDVAF.
OrthoDBiEOG7R2BVR.

Family and domain databases

Gene3Di2.70.130.10. 1 hit.
InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WCG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIRRIRTLTP LLVLACAGSG AWASKKAFNI QDDLLAYPQF QVFFPDEYIL
60 70 80 90 100
DARARELLQN QQESSSASAD KTFSEGNDAQ VYLGSRKDQS EDVNKETIEG
110 120 130 140 150
SGFTYEEMLL EGQRYLCSIP QVDNGNRDQT NGAESTSKED EQREIARATD
160 170 180 190 200
RGLELLREME GKCMYYISGW WSYSFCYKKQ IKQFHALPSG PGVPNYPPIE
210 220 230 240 250
DSTTHSFVLG RFPNSGDDED LEGDAEHKKT TTDVAELQTK GGSRYLVQRL
260 270 280 290 300
GGGTKCDLTG KDRKIEVQFH CHPQSTDRIG WIKELTTCSY LMVIYTPRLC
310 320 330 340 350
NDVAFLPPQQ DEAHAIECRE ILSEEEVSDW EANREYHLAQ QLVESAITPE
360 370 380 390 400
FPVVGDIEVG AHKWVGSEGK QIEKGRVASI GEEKIEVVAK RQNGEITRLS
410 420 430 440 450
KEELKKYGLD PEKIETLKSR LEELAKGKDW TLEIVESNGE RGLVGTVDSN
460 470 480 490 500
DDEKEDHAAQ GSISQPAQGT TADKGESNAE TGEEKKKADE KIDHYEPEKS
510 520
GPTTDDADDG SEEIFFKDEL
Length:520
Mass (Da):58,265
Last modified:July 5, 2005 - v1
Checksum:iCAD972BBB859CF98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000013 Genomic DNA. Translation: EAL85222.1.
RefSeqiXP_747260.1. XM_742167.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00003023; CADAFUAP00003023; CADAFUAG00003023.
GeneIDi3504663.
KEGGiafm:AFUA_8G04530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000013 Genomic DNA. Translation: EAL85222.1 .
RefSeqi XP_747260.1. XM_742167.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00003023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00003023 ; CADAFUAP00003023 ; CADAFUAG00003023 .
GeneIDi 3504663.
KEGGi afm:AFUA_8G04530.

Phylogenomic databases

eggNOGi NOG309879.
HOGENOMi HOG000157538.
InParanoidi Q4WCG2.
KOi K10088.
OMAi LCDDVAF.
OrthoDBi EOG7R2BVR.

Family and domain databases

Gene3Di 2.70.130.10. 1 hit.
InterProi IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view ]
Pfami PF07915. PRKCSH. 1 hit.
[Graphical view ]
SUPFAMi SSF50911. SSF50911. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiOS9_ASPFU
AccessioniPrimary (citable) accession number: Q4WCG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3