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Q4WC60

- BTGE_ASPFU

UniProt

Q4WC60 - BTGE_ASPFU

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Protein

Probable beta-glucosidase btgE

Gene

btgE

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei501 – 5011NucleophileBy similarity
Active sitei555 – 5551Proton donorBy similarity

GO - Molecular functioni

  1. beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase btgE (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase btgE
Cellobiase btgE
Gentiobiase btgE
Gene namesi
Name:btgE
ORF Names:AFUA_8G05610
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 8

Subcellular locationi

Secretedcell wall By similarity
Note: Covalently-linked to the cell wall.By similarity

GO - Cellular componenti

  1. cell wall Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 565547Probable beta-glucosidase btgEPRO_0000395133Add
BLAST

Proteomic databases

PRIDEiQ4WC60.

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00003231.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 287244Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5309.
HOGENOMiHOG000158427.
InParanoidiQ4WC60.
KOiK01238.
OrthoDBiEOG73FQWG.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4WC60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGAILATAA ALAGTAMADV AHMRRHGHDS FHQRRSPLAE ADATCGCTTE
60 70 80 90 100
VVTVWGPPTL IPVASPTPST VTSEAVTTLH STSTTTVTVI ASASTPAASP
110 120 130 140 150
SPATDKVPLP TPAITNFPST GVYTIPATTV TVFDTTTVCG ATTTELPAGT
160 170 180 190 200
HTYGGVTTVV ETATTVVCPY ATVEPSGTTV TSVIKTTTYV CPSAGTYTIA
210 220 230 240 250
PTTTTVPTST VIVYPTPAVI TPGTYTQPEQ TVTVTRTDYT YVCPFTGQDE
260 270 280 290 300
PTSAPAAPST TAVPATTTAA PETTTAAPDT TTAVPSTSSA APSSSSTAPA
310 320 330 340 350
STGAVSGQMG MTYTPYTKGG DCKDKSSVLS EVAALKSKGF THVRVYSTDC
360 370 380 390 400
NSLEYIGEAA RTSGLQMIIG VFISSTGVSG AQDQVTAISK WAQWDLVSLI
410 420 430 440 450
VVGNEAIQNG YCDASTLAGF ISSAKSAFQA AGYTGKVTTT EPINVWQAHG
460 470 480 490 500
STLCGVCDIV GANIHPFFNA DVSADQAGKF VAQEIKVLES ICPGKDVLNL
510 520 530 540 550
ETGWPHAGNA NGKAVPGTSE QAIAIKSIAD EVGSKSVFFS YFDDLWKEPG
560
QFGVERYWGC FDTFN
Length:565
Mass (Da):58,148
Last modified:June 15, 2010 - v2
Checksum:i4D06B871D8835ACC
GO

Sequence cautioni

The sequence EAL85324.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000013 Genomic DNA. Translation: EAL85324.1. Sequence problems.
RefSeqiXP_747362.1. XM_742269.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00003231; CADAFUAP00003231; CADAFUAG00003231.
GeneIDi3504706.
KEGGiafm:AFUA_8G05610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000013 Genomic DNA. Translation: EAL85324.1 . Sequence problems.
RefSeqi XP_747362.1. XM_742269.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00003231.

Proteomic databases

PRIDEi Q4WC60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00003231 ; CADAFUAP00003231 ; CADAFUAG00003231 .
GeneIDi 3504706.
KEGGi afm:AFUA_8G05610.

Phylogenomic databases

eggNOGi COG5309.
HOGENOMi HOG000158427.
InParanoidi Q4WC60.
KOi K01238.
OrthoDBi EOG73FQWG.

Enzyme and pathway databases

UniPathwayi UPA00696 .

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiBTGE_ASPFU
AccessioniPrimary (citable) accession number: Q4WC60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3