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Q4WC60

- BTGE_ASPFU

UniProt

Q4WC60 - BTGE_ASPFU

Protein

Probable beta-glucosidase btgE

Gene

btgE

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose By similarity.By similarity

    Catalytic activityi

    Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei501 – 5011NucleophileBy similarity
    Active sitei555 – 5551Proton donorBy similarity

    GO - Molecular functioni

    1. beta-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellulose catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

    Enzyme and pathway databases

    UniPathwayiUPA00696.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-glucosidase btgE (EC:3.2.1.21)
    Alternative name(s):
    Beta-D-glucoside glucohydrolase btgE
    Cellobiase btgE
    Gentiobiase btgE
    Gene namesi
    Name:btgE
    ORF Names:AFUA_8G05610
    OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    Taxonomic identifieri330879 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000002530: Chromosome 8

    Subcellular locationi

    Secretedcell wall By similarity
    Note: Covalently-linked to the cell wall.By similarity

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 565547Probable beta-glucosidase btgEPRO_0000395133Add
    BLAST

    Proteomic databases

    PRIDEiQ4WC60.

    Interactioni

    Protein-protein interaction databases

    STRINGi5085.CADAFUAP00003231.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 287244Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 17 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5309.
    HOGENOMiHOG000158427.
    KOiK01238.
    OrthoDBiEOG73FQWG.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4WC60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGAILATAA ALAGTAMADV AHMRRHGHDS FHQRRSPLAE ADATCGCTTE    50
    VVTVWGPPTL IPVASPTPST VTSEAVTTLH STSTTTVTVI ASASTPAASP 100
    SPATDKVPLP TPAITNFPST GVYTIPATTV TVFDTTTVCG ATTTELPAGT 150
    HTYGGVTTVV ETATTVVCPY ATVEPSGTTV TSVIKTTTYV CPSAGTYTIA 200
    PTTTTVPTST VIVYPTPAVI TPGTYTQPEQ TVTVTRTDYT YVCPFTGQDE 250
    PTSAPAAPST TAVPATTTAA PETTTAAPDT TTAVPSTSSA APSSSSTAPA 300
    STGAVSGQMG MTYTPYTKGG DCKDKSSVLS EVAALKSKGF THVRVYSTDC 350
    NSLEYIGEAA RTSGLQMIIG VFISSTGVSG AQDQVTAISK WAQWDLVSLI 400
    VVGNEAIQNG YCDASTLAGF ISSAKSAFQA AGYTGKVTTT EPINVWQAHG 450
    STLCGVCDIV GANIHPFFNA DVSADQAGKF VAQEIKVLES ICPGKDVLNL 500
    ETGWPHAGNA NGKAVPGTSE QAIAIKSIAD EVGSKSVFFS YFDDLWKEPG 550
    QFGVERYWGC FDTFN 565
    Length:565
    Mass (Da):58,148
    Last modified:June 15, 2010 - v2
    Checksum:i4D06B871D8835ACC
    GO

    Sequence cautioni

    The sequence EAL85324.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000013 Genomic DNA. Translation: EAL85324.1. Sequence problems.
    RefSeqiXP_747362.1. XM_742269.1.

    Genome annotation databases

    EnsemblFungiiCADAFUAT00003231; CADAFUAP00003231; CADAFUAG00003231.
    GeneIDi3504706.
    KEGGiafm:AFUA_8G05610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAHF01000013 Genomic DNA. Translation: EAL85324.1 . Sequence problems.
    RefSeqi XP_747362.1. XM_742269.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5085.CADAFUAP00003231.

    Proteomic databases

    PRIDEi Q4WC60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADAFUAT00003231 ; CADAFUAP00003231 ; CADAFUAG00003231 .
    GeneIDi 3504706.
    KEGGi afm:AFUA_8G05610.

    Phylogenomic databases

    eggNOGi COG5309.
    HOGENOMi HOG000158427.
    KOi K01238.
    OrthoDBi EOG73FQWG.

    Enzyme and pathway databases

    UniPathwayi UPA00696 .

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
      Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
      , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
      Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

    Entry informationi

    Entry nameiBTGE_ASPFU
    AccessioniPrimary (citable) accession number: Q4WC60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3