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Protein

Probable beta-glucosidase K

Gene

bglK

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).By similarity

Catalytic activityi

Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.

Pathwayi: cellulose degradation

This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei232By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Enzyme and pathway databases

UniPathwayiUPA00696

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-glucosidase K (EC:3.2.1.21)
Alternative name(s):
Beta-D-glucoside glucohydrolase K
Cellobiase K
Gentiobiase K
Gene namesi
Name:bglK
ORF Names:AFUA_7G00240
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 7, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu7g00240

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003948971 – 767Probable beta-glucosidase KAdd BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi749N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ4WA69

Structurei

3D structure databases

ProteinModelPortaliQ4WA69
SMRiQ4WA69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini405 – 552PA14PROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family.Curated

Phylogenomic databases

HOGENOMiHOG000031215
InParanoidiQ4WA69
KOiK05349
OMAiGNECIAK
OrthoDBiEOG092C0SKR

Family and domain databases

Gene3Di2.60.120.260, 1 hit
3.20.20.300, 2 hits
3.40.50.1700, 2 hits
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR019800 Glyco_hydro_3_AS
IPR002772 Glyco_hydro_3_C
IPR036881 Glyco_hydro_3_C_sf
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
IPR037524 PA14/GLEYA
IPR011658 PA14_dom
PfamiView protein in Pfam
PF00933 Glyco_hydro_3, 1 hit
PF01915 Glyco_hydro_3_C, 1 hit
PF07691 PA14, 1 hit
PRINTSiPR00133 GLHYDRLASE3
SMARTiView protein in SMART
SM00758 PA14, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
SSF52279 SSF52279, 2 hits
PROSITEiView protein in PROSITE
PS00775 GLYCOSYL_HYDROL_F3, 1 hit
PS51820 PA14, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WA69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEICPRRED FDIDYILKNA SLLEKVSLLA GYDFWHTAPL PRFNVPSVRV
60 70 80 90 100
SDGPNGVRGT KFFDGVRAAC LPCGTGLAAT WDQSLLYDAG VLIGQECLAK
110 120 130 140 150
GAHCWLVPTV CIQRSPLGGR GFESFAEDPY ATGKLAAAYI RGAQSTGVIS
160 170 180 190 200
TIKHFAANDQ EHERISVNAV MSERALREVH LLPFQIAIAD SAPGAVMTCY
210 220 230 240 250
NKVNGQHLSE SKEMLDGLLR REWGWKGLIM SDWFGTYSTA EALNAGLGLE
260 270 280 290 300
MPGTTRLRGP LLELAISSRK VSRATLDERA RTVLEFVQRA RKAEVSAVES
310 320 330 340 350
TRDFPEDRRL NRKLAADSIV LLKNESGLLP LNPQTLTSVA LIGPNMKTAA
360 370 380 390 400
FCGGGSASLQ PYYSTSPYQG ITSQLPPGVE VLYETGATSY AFIPELEASE
410 420 430 440 450
VRTPEGQPGL RMRFYRDPPS VQERRVLMGF SNPELDRLFY ADIEAELIAP
460 470 480 490 500
ATGPFQFGLA VYGSASLFLN DQLIIDNTTV QRGGTFFFGK GTLEETATVD
510 520 530 540 550
LVQGQSYQIK VQFASGPSSK LVKPGVVNFG GGAGRLGMVQ VVDPERAIAR
560 570 580 590 600
AVEAAKRADI TILGVGLTRD HESEGFDRSH MDLPPAVASL VTAVLDVAPD
610 620 630 640 650
AILLTQSGTP FSMLPWADLV KTHLHAWFGG NELGNGIADV LFGVVNPSGK
660 670 680 690 700
LPLSFPRRIE DTPTYLNFGS ERGQVTYGEG IYVGYKLLRK SPTSCALSIR
710 720 730 740 750
ARFVVHLLCV LRFDGRHRVR YTECSKLGRR GRSGSSPAVY RGRSNNVVNR
760
TSHQGAQRIS KGGFAAR
Length:767
Mass (Da):83,358
Last modified:July 5, 2005 - v1
Checksum:iBF4924E3FE58BC4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000015 Genomic DNA Translation: EAL84867.1
RefSeqiXP_746905.1, XM_741812.1

Genome annotation databases

EnsemblFungiiCADAFUAT00001243; CADAFUAP00001243; CADAFUAG00001243
GeneIDi3504260
KEGGiafm:AFUA_7G00240

Similar proteinsi

Entry informationi

Entry nameiBGLK_ASPFU
AccessioniPrimary (citable) accession number: Q4WA69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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