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Q4WA15

- NTE1_ASPFU

UniProt

Q4WA15 - NTE1_ASPFU

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Protein
Lysophospholipase nte1
Gene
nte1, AFUA_4G03000
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1252 – 12521 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi680 – 800121cNMP 1
Add
BLAST
Nucleotide bindingi840 – 960121cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:AFUA_4G03000
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565Cytoplasmic By similarity
Add
BLAST
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Topological domaini87 – 10822Lumenal By similarity
Add
BLAST
Transmembranei109 – 12921Helical; Reviewed prediction
Add
BLAST
Topological domaini130 – 15221393Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15221522Lysophospholipase nte1
PRO_0000295310Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00001452.

Structurei

3D structure databases

ProteinModelPortaliQ4WA15.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1219 – 1383165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1250 – 12545GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 2713Poly-Ser
Add
BLAST
Compositional biasi52 – 609Poly-Pro
Compositional biasi293 – 3008Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WA15-1 [UniParc]FASTAAdd to Basket

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MADGVTQVDS TGLHSFSPSP SLSSSSSLPA VALSLAVSAS AVTASYSISH     50
LPPPPLPPVP TTMAGWIGWV FSFFFQVIPS VLYWIITFST ITLPTWLFTL 100
FSMSLTFTMN FTTLLLIVLA VVSTISWFIR YRFLNMYSRL PPEPQRKEPQ 150
VDLFPDVQEG DSKPGLANYL DEFLSAIKVF GYLERPVFHE LTRTMQTRKL 200
IAGETLMLEE EKGFCLVVDG LVQIFVKSMR DGKSDTDEEL HHLGAESSDE 250
EHHIDGKQGY QLLTEVKNGA SMSSLFSILS LFTEDIQLRE NESSGSSSSS 300
IALRAARVPN SIPTSPRGVM DSPSLGFQDH SDDTSNMITN GELPSVPPLH 350
LGESRTPPSG DQHHQQHHES RKHSSRKRRK SVHPDIVARA MVDTTIAIIP 400
ASAFRRLTRV YPRATAHIVQ VILTRLQRVT FATAHSYLGL SNEVLGIEKQ 450
MTKFTTYDLP NNMRGAALDR LKDKFIKERD RLGSEEVTKG IALHNPSAGR 500
RRRSSSFLRK DAALQAKLMT PRRAATVVTP ESAPAEHDTY GVSPGDLLST 550
IQSSRFGPRY EQPPAKLQTP LAEKENTHFR LPAMQARHTF RRQDTMDEDG 600
LFRECILDCI MKGIGLTSST RDALRKSNHS GEASPKLLSY DSRRQKAIFT 650
NNAFGFIDPY EGSGDGETES LMSMSVTSAG GTSPVINLRE ELRNDIEIVY 700
FPKGSVLVEQ GERHPGLYYV IDGFLDVGVP IVDKGEDLVG VSKPAASKGS 750
FPTLKRTTTA NSVGAGGTAA NDSRRRKQSR KSLYLIKPGG IQGYVGAVAS 800
YRSYTDVVAK TDVYVGFLPR ASLERIAERY PIALLTLAKR LTSILPRLLL 850
HIDFALEWVQ VNAGQVIYRQ GDESDAIYLV LNGRLRSVLE SPGNKLAVVG 900
EYGQGESVGE LEVMTESTRP ATLHAIRDTE LAKFPRSLFN SLAQEHPGIT 950
IQVSKLIAQR MRDLVERPVT EKGVERSNAG SVQTATSTVN LRTVGILPVT 1000
AGVPVVEFGN RLLHALHQVG VTNGVTSLNQ AAILNHLGRH AFSKMGKLKL 1050
SQYLADLEEK YGMVLYIADT NVSSPWTQTC ITQADCILLV GLAESSPSIG 1100
EYERFLLGMK TTARKELVLL HAERYCPPGL TRRWLKNRVW INGGHHHIQM 1150
AFRLTAEPTH PETKRFGTVL KQRVQVLQAE IQKYTSRRIR QTPLYSAQSP 1200
FKGDFHRLAR RLCGRAVGLV LGGGGARGIA HVGVIKALEE AGIPVDIIGG 1250
TSIGSFIGAL YARDADVVPM YGRAKKFAGR MGSMWRFALD LTYPTVSYTT 1300
GHEFNRGIFK TFGDSQIEDF WLEFYCNTTN ISKSRPEYHS SGYVWRYVRA 1350
SMSLAGLIPP ICDEGSMLLD GGYIDNLTVD HMKGLGADVI FAVDVGSIDD 1400
NTPQVYGDSL SGFWSVFNRW NPFSSCPNPP TLSEIQARLA YVSSIDNLER 1450
AKNIPGCLYM RPPIDGYGTL EFGKFDEIYQ VGYAFGKQFL EKLKSEGSLP 1500
LPEETEEKKK LQRTLAPRRA SI 1522
Length:1,522
Mass (Da):168,262
Last modified:July 5, 2005 - v1
Checksum:i4EB5CC71B03724B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000016 Genomic DNA. Translation: EAL84448.1.
RefSeqiXP_746486.1. XM_741393.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00001452; CADAFUAP00001452; CADAFUAG00001452.
GeneIDi3503855.
KEGGiafm:AFUA_4G03000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAHF01000016 Genomic DNA. Translation: EAL84448.1 .
RefSeqi XP_746486.1. XM_741393.1.

3D structure databases

ProteinModelPortali Q4WA15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00001452.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00001452 ; CADAFUAP00001452 ; CADAFUAG00001452 .
GeneIDi 3503855.
KEGGi afm:AFUA_4G03000.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiNTE1_ASPFU
AccessioniPrimary (citable) accession number: Q4WA15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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