Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4WA15

- NTE1_ASPFU

UniProt

Q4WA15 - NTE1_ASPFU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lysophospholipase nte1

Gene

nte1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1252 – 12521By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi680 – 800121cNMP 1Add
BLAST
Nucleotide bindingi840 – 960121cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:AFUA_4G03000
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000002530: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565CytoplasmicBy similarityAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Topological domaini87 – 10822LumenalBy similarityAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Topological domaini130 – 15221393CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15221522Lysophospholipase nte1PRO_0000295310Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUAP00001452.

Structurei

3D structure databases

ProteinModelPortaliQ4WA15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1219 – 1383165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1250 – 12545GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 2713Poly-SerAdd
BLAST
Compositional biasi52 – 609Poly-Pro
Compositional biasi293 – 3008Poly-Ser

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ4WA15.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4WA15-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADGVTQVDS TGLHSFSPSP SLSSSSSLPA VALSLAVSAS AVTASYSISH
60 70 80 90 100
LPPPPLPPVP TTMAGWIGWV FSFFFQVIPS VLYWIITFST ITLPTWLFTL
110 120 130 140 150
FSMSLTFTMN FTTLLLIVLA VVSTISWFIR YRFLNMYSRL PPEPQRKEPQ
160 170 180 190 200
VDLFPDVQEG DSKPGLANYL DEFLSAIKVF GYLERPVFHE LTRTMQTRKL
210 220 230 240 250
IAGETLMLEE EKGFCLVVDG LVQIFVKSMR DGKSDTDEEL HHLGAESSDE
260 270 280 290 300
EHHIDGKQGY QLLTEVKNGA SMSSLFSILS LFTEDIQLRE NESSGSSSSS
310 320 330 340 350
IALRAARVPN SIPTSPRGVM DSPSLGFQDH SDDTSNMITN GELPSVPPLH
360 370 380 390 400
LGESRTPPSG DQHHQQHHES RKHSSRKRRK SVHPDIVARA MVDTTIAIIP
410 420 430 440 450
ASAFRRLTRV YPRATAHIVQ VILTRLQRVT FATAHSYLGL SNEVLGIEKQ
460 470 480 490 500
MTKFTTYDLP NNMRGAALDR LKDKFIKERD RLGSEEVTKG IALHNPSAGR
510 520 530 540 550
RRRSSSFLRK DAALQAKLMT PRRAATVVTP ESAPAEHDTY GVSPGDLLST
560 570 580 590 600
IQSSRFGPRY EQPPAKLQTP LAEKENTHFR LPAMQARHTF RRQDTMDEDG
610 620 630 640 650
LFRECILDCI MKGIGLTSST RDALRKSNHS GEASPKLLSY DSRRQKAIFT
660 670 680 690 700
NNAFGFIDPY EGSGDGETES LMSMSVTSAG GTSPVINLRE ELRNDIEIVY
710 720 730 740 750
FPKGSVLVEQ GERHPGLYYV IDGFLDVGVP IVDKGEDLVG VSKPAASKGS
760 770 780 790 800
FPTLKRTTTA NSVGAGGTAA NDSRRRKQSR KSLYLIKPGG IQGYVGAVAS
810 820 830 840 850
YRSYTDVVAK TDVYVGFLPR ASLERIAERY PIALLTLAKR LTSILPRLLL
860 870 880 890 900
HIDFALEWVQ VNAGQVIYRQ GDESDAIYLV LNGRLRSVLE SPGNKLAVVG
910 920 930 940 950
EYGQGESVGE LEVMTESTRP ATLHAIRDTE LAKFPRSLFN SLAQEHPGIT
960 970 980 990 1000
IQVSKLIAQR MRDLVERPVT EKGVERSNAG SVQTATSTVN LRTVGILPVT
1010 1020 1030 1040 1050
AGVPVVEFGN RLLHALHQVG VTNGVTSLNQ AAILNHLGRH AFSKMGKLKL
1060 1070 1080 1090 1100
SQYLADLEEK YGMVLYIADT NVSSPWTQTC ITQADCILLV GLAESSPSIG
1110 1120 1130 1140 1150
EYERFLLGMK TTARKELVLL HAERYCPPGL TRRWLKNRVW INGGHHHIQM
1160 1170 1180 1190 1200
AFRLTAEPTH PETKRFGTVL KQRVQVLQAE IQKYTSRRIR QTPLYSAQSP
1210 1220 1230 1240 1250
FKGDFHRLAR RLCGRAVGLV LGGGGARGIA HVGVIKALEE AGIPVDIIGG
1260 1270 1280 1290 1300
TSIGSFIGAL YARDADVVPM YGRAKKFAGR MGSMWRFALD LTYPTVSYTT
1310 1320 1330 1340 1350
GHEFNRGIFK TFGDSQIEDF WLEFYCNTTN ISKSRPEYHS SGYVWRYVRA
1360 1370 1380 1390 1400
SMSLAGLIPP ICDEGSMLLD GGYIDNLTVD HMKGLGADVI FAVDVGSIDD
1410 1420 1430 1440 1450
NTPQVYGDSL SGFWSVFNRW NPFSSCPNPP TLSEIQARLA YVSSIDNLER
1460 1470 1480 1490 1500
AKNIPGCLYM RPPIDGYGTL EFGKFDEIYQ VGYAFGKQFL EKLKSEGSLP
1510 1520
LPEETEEKKK LQRTLAPRRA SI
Length:1,522
Mass (Da):168,262
Last modified:July 5, 2005 - v1
Checksum:i4EB5CC71B03724B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000016 Genomic DNA. Translation: EAL84448.1.
RefSeqiXP_746486.1. XM_741393.1.

Genome annotation databases

EnsemblFungiiCADAFUAT00001452; CADAFUAP00001452; CADAFUAG00001452.
GeneIDi3503855.
KEGGiafm:AFUA_4G03000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000016 Genomic DNA. Translation: EAL84448.1 .
RefSeqi XP_746486.1. XM_741393.1.

3D structure databases

ProteinModelPortali Q4WA15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5085.CADAFUAP00001452.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADAFUAT00001452 ; CADAFUAP00001452 ; CADAFUAG00001452 .
GeneIDi 3503855.
KEGGi afm:AFUA_4G03000.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
InParanoidi Q4WA15.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
    Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.
    , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
    Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Entry informationi

Entry nameiNTE1_ASPFU
AccessioniPrimary (citable) accession number: Q4WA15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3