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Q4WA15 (NTE1_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase nte1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:nte1
ORF Names:AFUA_4G03000
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome]
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length1522 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15221522Lysophospholipase nte1
PRO_0000295310

Regions

Topological domain1 – 6565Cytoplasmic By similarity
Transmembrane66 – 8621Helical; Potential
Topological domain87 – 10822Lumenal By similarity
Transmembrane109 – 12921Helical; Potential
Topological domain130 – 15221393Cytoplasmic By similarity
Domain1219 – 1383165Patatin
Nucleotide binding680 – 800121cNMP 1
Nucleotide binding840 – 960121cNMP 2
Motif1250 – 12545GXSXG
Compositional bias15 – 2713Poly-Ser
Compositional bias52 – 609Poly-Pro
Compositional bias293 – 3008Poly-Ser

Sites

Active site12521 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4WA15 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 4EB5CC71B03724B3

FASTA1,522168,262
        10         20         30         40         50         60 
MADGVTQVDS TGLHSFSPSP SLSSSSSLPA VALSLAVSAS AVTASYSISH LPPPPLPPVP 

        70         80         90        100        110        120 
TTMAGWIGWV FSFFFQVIPS VLYWIITFST ITLPTWLFTL FSMSLTFTMN FTTLLLIVLA 

       130        140        150        160        170        180 
VVSTISWFIR YRFLNMYSRL PPEPQRKEPQ VDLFPDVQEG DSKPGLANYL DEFLSAIKVF 

       190        200        210        220        230        240 
GYLERPVFHE LTRTMQTRKL IAGETLMLEE EKGFCLVVDG LVQIFVKSMR DGKSDTDEEL 

       250        260        270        280        290        300 
HHLGAESSDE EHHIDGKQGY QLLTEVKNGA SMSSLFSILS LFTEDIQLRE NESSGSSSSS 

       310        320        330        340        350        360 
IALRAARVPN SIPTSPRGVM DSPSLGFQDH SDDTSNMITN GELPSVPPLH LGESRTPPSG 

       370        380        390        400        410        420 
DQHHQQHHES RKHSSRKRRK SVHPDIVARA MVDTTIAIIP ASAFRRLTRV YPRATAHIVQ 

       430        440        450        460        470        480 
VILTRLQRVT FATAHSYLGL SNEVLGIEKQ MTKFTTYDLP NNMRGAALDR LKDKFIKERD 

       490        500        510        520        530        540 
RLGSEEVTKG IALHNPSAGR RRRSSSFLRK DAALQAKLMT PRRAATVVTP ESAPAEHDTY 

       550        560        570        580        590        600 
GVSPGDLLST IQSSRFGPRY EQPPAKLQTP LAEKENTHFR LPAMQARHTF RRQDTMDEDG 

       610        620        630        640        650        660 
LFRECILDCI MKGIGLTSST RDALRKSNHS GEASPKLLSY DSRRQKAIFT NNAFGFIDPY 

       670        680        690        700        710        720 
EGSGDGETES LMSMSVTSAG GTSPVINLRE ELRNDIEIVY FPKGSVLVEQ GERHPGLYYV 

       730        740        750        760        770        780 
IDGFLDVGVP IVDKGEDLVG VSKPAASKGS FPTLKRTTTA NSVGAGGTAA NDSRRRKQSR 

       790        800        810        820        830        840 
KSLYLIKPGG IQGYVGAVAS YRSYTDVVAK TDVYVGFLPR ASLERIAERY PIALLTLAKR 

       850        860        870        880        890        900 
LTSILPRLLL HIDFALEWVQ VNAGQVIYRQ GDESDAIYLV LNGRLRSVLE SPGNKLAVVG 

       910        920        930        940        950        960 
EYGQGESVGE LEVMTESTRP ATLHAIRDTE LAKFPRSLFN SLAQEHPGIT IQVSKLIAQR 

       970        980        990       1000       1010       1020 
MRDLVERPVT EKGVERSNAG SVQTATSTVN LRTVGILPVT AGVPVVEFGN RLLHALHQVG 

      1030       1040       1050       1060       1070       1080 
VTNGVTSLNQ AAILNHLGRH AFSKMGKLKL SQYLADLEEK YGMVLYIADT NVSSPWTQTC 

      1090       1100       1110       1120       1130       1140 
ITQADCILLV GLAESSPSIG EYERFLLGMK TTARKELVLL HAERYCPPGL TRRWLKNRVW 

      1150       1160       1170       1180       1190       1200 
INGGHHHIQM AFRLTAEPTH PETKRFGTVL KQRVQVLQAE IQKYTSRRIR QTPLYSAQSP 

      1210       1220       1230       1240       1250       1260 
FKGDFHRLAR RLCGRAVGLV LGGGGARGIA HVGVIKALEE AGIPVDIIGG TSIGSFIGAL 

      1270       1280       1290       1300       1310       1320 
YARDADVVPM YGRAKKFAGR MGSMWRFALD LTYPTVSYTT GHEFNRGIFK TFGDSQIEDF 

      1330       1340       1350       1360       1370       1380 
WLEFYCNTTN ISKSRPEYHS SGYVWRYVRA SMSLAGLIPP ICDEGSMLLD GGYIDNLTVD 

      1390       1400       1410       1420       1430       1440 
HMKGLGADVI FAVDVGSIDD NTPQVYGDSL SGFWSVFNRW NPFSSCPNPP TLSEIQARLA 

      1450       1460       1470       1480       1490       1500 
YVSSIDNLER AKNIPGCLYM RPPIDGYGTL EFGKFDEIYQ VGYAFGKQFL EKLKSEGSLP 

      1510       1520 
LPEETEEKKK LQRTLAPRRA SI 

« Hide

References

[1]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAHF01000016 Genomic DNA. Translation: EAL84448.1.
RefSeqXP_746486.1. XM_741393.1.

3D structure databases

ProteinModelPortalQ4WA15.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5085.CADAFUAP00001452.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADAFUAT00001452; CADAFUAP00001452; CADAFUAG00001452.
GeneID3503855.
KEGGafm:AFUA_4G03000.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OMASPWTQTC.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_ASPFU
AccessionPrimary (citable) accession number: Q4WA15
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2005
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families