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Protein

Lysophospholipase nte1

Gene

nte1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1252NucleophilePROSITE-ProRule annotation1
Active sitei1370Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi680 – 800cNMP 1Add BLAST121
Nucleotide bindingi840 – 960cNMP 2Add BLAST121

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase nte1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:nte1
ORF Names:AFUA_4G03000
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu4g03000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65CytoplasmicBy similarityAdd BLAST65
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 108LumenalBy similarityAdd BLAST22
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 1522CytoplasmicBy similarityAdd BLAST1393

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002953101 – 1522Lysophospholipase nte1Add BLAST1522

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00009732

Structurei

3D structure databases

ProteinModelPortaliQ4WA15
SMRiQ4WA15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1219 – 1383PNPLAPROSITE-ProRule annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1223 – 1228GXGXXGPROSITE-ProRule annotation6
Motifi1250 – 1254GXSXGPROSITE-ProRule annotation5
Motifi1370 – 1372DGA/GPROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 27Poly-SerAdd BLAST13
Compositional biasi52 – 60Poly-Pro9
Compositional biasi293 – 300Poly-Ser8

Sequence similaritiesi

Belongs to the NTE family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000048680
InParanoidiQ4WA15
KOiK14676
OMAiSPWTQTC
OrthoDBiEOG092C0BAH

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR016035 Acyl_Trfase/lysoPLipase
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR001423 LysoPLipase_patatin_CS
IPR002641 PNPLA_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF01734 Patatin, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 2 hits
SUPFAMiSSF51206 SSF51206, 5 hits
SSF52151 SSF52151, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 2 hits
PS51635 PNPLA, 1 hit
PS01237 UPF0028, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WA15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGVTQVDS TGLHSFSPSP SLSSSSSLPA VALSLAVSAS AVTASYSISH
60 70 80 90 100
LPPPPLPPVP TTMAGWIGWV FSFFFQVIPS VLYWIITFST ITLPTWLFTL
110 120 130 140 150
FSMSLTFTMN FTTLLLIVLA VVSTISWFIR YRFLNMYSRL PPEPQRKEPQ
160 170 180 190 200
VDLFPDVQEG DSKPGLANYL DEFLSAIKVF GYLERPVFHE LTRTMQTRKL
210 220 230 240 250
IAGETLMLEE EKGFCLVVDG LVQIFVKSMR DGKSDTDEEL HHLGAESSDE
260 270 280 290 300
EHHIDGKQGY QLLTEVKNGA SMSSLFSILS LFTEDIQLRE NESSGSSSSS
310 320 330 340 350
IALRAARVPN SIPTSPRGVM DSPSLGFQDH SDDTSNMITN GELPSVPPLH
360 370 380 390 400
LGESRTPPSG DQHHQQHHES RKHSSRKRRK SVHPDIVARA MVDTTIAIIP
410 420 430 440 450
ASAFRRLTRV YPRATAHIVQ VILTRLQRVT FATAHSYLGL SNEVLGIEKQ
460 470 480 490 500
MTKFTTYDLP NNMRGAALDR LKDKFIKERD RLGSEEVTKG IALHNPSAGR
510 520 530 540 550
RRRSSSFLRK DAALQAKLMT PRRAATVVTP ESAPAEHDTY GVSPGDLLST
560 570 580 590 600
IQSSRFGPRY EQPPAKLQTP LAEKENTHFR LPAMQARHTF RRQDTMDEDG
610 620 630 640 650
LFRECILDCI MKGIGLTSST RDALRKSNHS GEASPKLLSY DSRRQKAIFT
660 670 680 690 700
NNAFGFIDPY EGSGDGETES LMSMSVTSAG GTSPVINLRE ELRNDIEIVY
710 720 730 740 750
FPKGSVLVEQ GERHPGLYYV IDGFLDVGVP IVDKGEDLVG VSKPAASKGS
760 770 780 790 800
FPTLKRTTTA NSVGAGGTAA NDSRRRKQSR KSLYLIKPGG IQGYVGAVAS
810 820 830 840 850
YRSYTDVVAK TDVYVGFLPR ASLERIAERY PIALLTLAKR LTSILPRLLL
860 870 880 890 900
HIDFALEWVQ VNAGQVIYRQ GDESDAIYLV LNGRLRSVLE SPGNKLAVVG
910 920 930 940 950
EYGQGESVGE LEVMTESTRP ATLHAIRDTE LAKFPRSLFN SLAQEHPGIT
960 970 980 990 1000
IQVSKLIAQR MRDLVERPVT EKGVERSNAG SVQTATSTVN LRTVGILPVT
1010 1020 1030 1040 1050
AGVPVVEFGN RLLHALHQVG VTNGVTSLNQ AAILNHLGRH AFSKMGKLKL
1060 1070 1080 1090 1100
SQYLADLEEK YGMVLYIADT NVSSPWTQTC ITQADCILLV GLAESSPSIG
1110 1120 1130 1140 1150
EYERFLLGMK TTARKELVLL HAERYCPPGL TRRWLKNRVW INGGHHHIQM
1160 1170 1180 1190 1200
AFRLTAEPTH PETKRFGTVL KQRVQVLQAE IQKYTSRRIR QTPLYSAQSP
1210 1220 1230 1240 1250
FKGDFHRLAR RLCGRAVGLV LGGGGARGIA HVGVIKALEE AGIPVDIIGG
1260 1270 1280 1290 1300
TSIGSFIGAL YARDADVVPM YGRAKKFAGR MGSMWRFALD LTYPTVSYTT
1310 1320 1330 1340 1350
GHEFNRGIFK TFGDSQIEDF WLEFYCNTTN ISKSRPEYHS SGYVWRYVRA
1360 1370 1380 1390 1400
SMSLAGLIPP ICDEGSMLLD GGYIDNLTVD HMKGLGADVI FAVDVGSIDD
1410 1420 1430 1440 1450
NTPQVYGDSL SGFWSVFNRW NPFSSCPNPP TLSEIQARLA YVSSIDNLER
1460 1470 1480 1490 1500
AKNIPGCLYM RPPIDGYGTL EFGKFDEIYQ VGYAFGKQFL EKLKSEGSLP
1510 1520
LPEETEEKKK LQRTLAPRRA SI
Length:1,522
Mass (Da):168,262
Last modified:July 5, 2005 - v1
Checksum:i4EB5CC71B03724B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000016 Genomic DNA Translation: EAL84448.1
RefSeqiXP_746486.1, XM_741393.1

Genome annotation databases

EnsemblFungiiCADAFUAT00001452; CADAFUAP00001452; CADAFUAG00001452
GeneIDi3503855
KEGGiafm:AFUA_4G03000

Similar proteinsi

Entry informationi

Entry nameiNTE1_ASPFU
AccessioniPrimary (citable) accession number: Q4WA15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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