Q4W9B8 (K6PF_ASPFU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 6-phosphofructokinase Short name=Phosphofructokinase EC=2.7.1.11 Alternative name(s): 6PF-1-K Phosphohexokinase | ||||
| Gene names |
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| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) [Reference proteome] | ||||
| Taxonomic identifier | 330879 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › ![]() |
Protein attributes
| Sequence length | 808 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the phosphofructokinase family. Two domains subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Cellular component | Cytoplasm |
| Domain | Repeat |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Allosteric enzyme Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | fructose 6-phosphate metabolic process Inferred from electronic annotation. Source: InterPro glycolysisInferred from electronic annotation. Source: UniProtKB-UniPathway |
| Cellular_component | 6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro |
| Molecular_function | 6-phosphofructokinase activity Inferred from electronic annotation. Source: EC ATP bindingInferred from electronic annotation. Source: UniProtKB-KW metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 808 | 808 | 6-phosphofructokinase | PRO_0000112034 | |||||
Regions | |||||||||
| Nucleotide binding | 33 – 37 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 191 – 195 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 208 – 224 | 17 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 164 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 222 | 1 | Magnesium; via carbonyl oxygen By similarity | ||||||
| Binding site | 199 | 1 | Substrate By similarity | ||||||
| Binding site | 291 | 1 | Substrate By similarity | ||||||
| Binding site | 297 | 1 | Substrate By similarity | ||||||
| Binding site | 300 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. Denning D.W.Nature 438:1151-1156(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AAHF01000017 Genomic DNA. Translation: EAL84323.1. |
| RefSeq | XP_746361.1. XM_741268.1. |
3D structure databases | |
| ProteinModelPortal | Q4W9B8. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 5085.CADAFUAP00002374. |
Proteomic databases | |
| PRIDE | Q4W9B8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | CADAFUAT00002374; CADAFUAP00002374; CADAFUAG00002374. |
| GeneID | 3503711. |
| KEGG | afm:AFUA_4G00960. |
Phylogenomic databases | |
| eggNOG | COG0205. |
| HOGENOM | HOG000200154. |
| KO | K00850. |
| OMA | PISSSYV. |
| OrthoDB | EOG418FWH. |
Enzyme and pathway databases | |
| UniPathway | UPA00109; UER00182. |
Family and domain databases | |
| InterPro | IPR009161. 6-phosphofructokinase_euk. IPR022953. Phosphofructokinase. IPR015912. Phosphofructokinase_CS. IPR000023. Phosphofructokinase_dom. [Graphical view] |
| Pfam | PF00365. PFK. 2 hits. [Graphical view] |
| PIRSF | PIRSF000533. ATP_PFK_euk. 1 hit. |
| PRINTS | PR00476. PHFRCTKINASE. |
| SUPFAM | SSF53784. Ppfruckinase. 2 hits. |
| TIGRFAMs | TIGR02478. 6PF1K_euk. 1 hit. |
| PROSITE | PS00433. PHOSPHOFRUCTOKINASE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | K6PF_ASPFU | ||||||||
| Accession | Primary (citable) accession number: Q4W9B8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
