Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adherens junction-associated protein 1

Gene

Ajap1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in cell adhesion and cell migration.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Adherens junction-associated protein 1
Gene namesi
Name:Ajap1
Synonyms:Neumo48
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1590138. Ajap1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 283ExtracellularSequence analysisAdd BLAST283
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Topological domaini305 – 411CytoplasmicSequence analysisAdd BLAST107

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002848031 – 411Adherens junction-associated protein 1Add BLAST411

Proteomic databases

PaxDbiQ4W8E7.
PRIDEiQ4W8E7.

PTM databases

iPTMnetiQ4W8E7.
PhosphoSitePlusiQ4W8E7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000050137.

Interactioni

Subunit structurei

Forms a complex with CDH1 and CTNNB1; interacts directly with CTNNB1. Interacts with AP1M2 and BSG/CD147 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064502.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni304 – 411Targeting signalsBy similarityAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi174 – 258Thr-richAdd BLAST85

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHN1. Eukaryota.
ENOG410YW4K. LUCA.
HOVERGENiHBG096853.
InParanoidiQ4W8E7.
PhylomeDBiQ4W8E7.

Family and domain databases

InterProiIPR029198. AJAP1_PANP_C.
[Graphical view]
PfamiPF15298. AJAP1_PANP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4W8E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWIQQLLGLS SMPIRWPGRS LGSHLWILIA MLQLAVDFPS CDSLGPGPEF
60 70 80 90 100
RLLSRPQRPQ RLWSLRTGPP TRLPTPAWSP RAARAERAHG PIQMQTPRAR
110 120 130 140 150
RAHRPRDQVA TLGPKGGLTK PPAATRSSPS LTSASASSSM TAGAAEHQSL
160 170 180 190 200
LKRGRRHTHD AEFNDFDFHG GRPTTETEFI AWGPTGDEEA LESNTFPGGF
210 220 230 240 250
GPTTVSILQT RKTTMAATTT TTAASTATAM TLQTKGVTES LDPWKRTPVG
260 270 280 290 300
VSTTEPSTSP SNNGKDIQPP RILGETSGLA VHQIITITVS LIMVIAALIT
310 320 330 340 350
TLVLKNCCAP SGHTRRNSHQ RKMNQQEESC QNLTDFTPAR VPSSVDIFTA
360 370 380 390 400
YNETLQCSHE CVRASVPVYA DETLHSTGEY KSTFNGNRSS SADRHLIPVA
410
FVSEKWFEIS C
Length:411
Mass (Da):44,755
Last modified:July 5, 2005 - v1
Checksum:i28533B826DD95FE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB179740 mRNA. Translation: BAD98504.1.
RefSeqiNP_001094484.1. NM_001101014.1.
UniGeneiRn.202629.

Genome annotation databases

GeneIDi687031.
KEGGirno:687031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB179740 mRNA. Translation: BAD98504.1.
RefSeqiNP_001094484.1. NM_001101014.1.
UniGeneiRn.202629.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064502.

PTM databases

iPTMnetiQ4W8E7.
PhosphoSitePlusiQ4W8E7.

Proteomic databases

PaxDbiQ4W8E7.
PRIDEiQ4W8E7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi687031.
KEGGirno:687031.

Organism-specific databases

CTDi55966.
RGDi1590138. Ajap1.

Phylogenomic databases

eggNOGiENOG410IHN1. Eukaryota.
ENOG410YW4K. LUCA.
HOVERGENiHBG096853.
InParanoidiQ4W8E7.
PhylomeDBiQ4W8E7.

Miscellaneous databases

PROiQ4W8E7.

Gene expression databases

BgeeiENSRNOG00000050137.

Family and domain databases

InterProiIPR029198. AJAP1_PANP_C.
[Graphical view]
PfamiPF15298. AJAP1_PANP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAJAP1_RAT
AccessioniPrimary (citable) accession number: Q4W8E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: July 5, 2005
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.