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Q4W5Z4

- DNM3A_CHICK

UniProt

Q4W5Z4 - DNM3A_CHICK

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Protein
DNA (cytosine-5)-methyltransferase 3A
Gene
DNMT3A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei629 – 6291S-adenosyl-L-methionine By similarity
Active sitei675 – 6751 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri458 – 48831GATA-type; atypical
Add
BLAST
Zinc fingeri499 – 55557PHD-type; atypical
Add
BLAST

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB
  2. DNA binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. C-5 methylation of cytosine Source: GOC
  2. DNA methylation Source: UniProtKB
  3. chromatin modification Source: UniProtKB-KW
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Protein family/group databases

REBASEi11753. M.GgaDnmt3AP.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 3A (EC:2.1.1.37)
Short name:
Dnmt3a
Gene namesi
Name:DNMT3A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. euchromatin Source: UniProtKB
  3. nuclear matrix Source: UniProtKB
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877DNA (cytosine-5)-methyltransferase 3A
PRO_0000313031Add
BLAST

Proteomic databases

PaxDbiQ4W5Z4.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006352.

Structurei

3D structure databases

ProteinModelPortaliQ4W5Z4.
SMRiQ4W5Z4. Positions 248-389, 592-877.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini226 – 28459PWWP
Add
BLAST
Domaini447 – 579133ADD
Add
BLAST
Domaini599 – 877279SAM-dependent MTase C5-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni606 – 6105S-adenosyl-L-methionine binding By similarity
Regioni651 – 6533S-adenosyl-L-methionine binding By similarity
Regioni856 – 8583S-adenosyl-L-methionine binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi448 – 49649Cys-rich
Add
BLAST

Domaini

The PWWP domain is essential for targeting to pericentric heterochromatin.

Sequence similaritiesi

Contains 1 ADD domain.
Contains 1 PWWP domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG70699.
HOVERGENiHBG051381.
KOiK17398.
PhylomeDBiQ4W5Z4.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025766. ADD.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025811. C5_MeTrfase_3.
IPR000313. PWWP_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF00145. DNA_methylase. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51533. ADD. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50812. PWWP. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4W5Z4-1 [UniParc]FASTAAdd to Basket

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MVESSDTPKD TAAVPKCPPP CPEASPAEPL PNGDLEADGA QWKGTEEGGA    50
SPKSGRPEED ETESLADGET GRALENGRCT PKEGLDAPAD EGELAPSDPQ 100
KKRGRRKLLE ATEKSKEEKE ENNFDSLKME GSRGRLRGGL GWESSLRQRP 150
MQRHTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NVVEETPRAE 200
PQKEEEASPP ASQQPTDPAS PNVATTPEPV VADAVDKNTS KSADDEPEYE 250
DGRGLGIGEL VWGKLRGFSW WPGRIVSWWM TGRSRAAEGT RWVMWFGDGK 300
FSVVCVEKLL PLSSFSSAFH QATYNKQPMY RKAIYEVLQV ASSRAGKIFP 350
ACPENDETDT SKVVEIQNKQ MIEWALGGFQ PSGPKGLEPP EEERNPYKEV 400
YTEMWVEPEA AAYAPPPPAK KPRKSTTEKP KVKEIIDERT RERLVYEVRQ 450
KCRNIEDICI SCGSLNVTLE HPLFIGGMCQ NCKNCFLECA YQYDDDGYQS 500
YCTICCGGRE VLMCGNNNCC RCFCVECVDL LVGPGAAQAA IKEDPWNCYM 550
CGHKGVYGLL RRREDWPSRL QMFFANNHDQ EFDPPKVYPP VPAEKRKPIR 600
VLSLFDGIAT GLLVLKDLGI QVDRYIASEV CEDSITVGMV RHQGKIMYVG 650
DVRNVTQKHI QEWGPFDLVI GGSPCNDLSI VNPARKGLYE GTGRLFFEFY 700
RLLHEARPKE GDDRPFFWLF ENVVAMGVSD KRDISRFLES NPVMIDAKEV 750
SAAHRARYFW GNLPGMNRPL ASTVNDKLEL QECLEHGRIA KFSKVRTITT 800
RSNSIKQGKD QHFPVFMNEK EDILWCTEME RVFGFPVHYT DVSNMSRLAR 850
QRLLGRSWSV PVIRHLFAPL KEYFACV 877
Length:877
Mass (Da):98,944
Last modified:July 5, 2005 - v1
Checksum:iFC7131DA1D40F84F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB214886 mRNA. Translation: BAD99023.1.
RefSeqiNP_001020003.1. NM_001024832.1.
UniGeneiGga.6002.

Genome annotation databases

GeneIDi421991.
KEGGigga:421991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB214886 mRNA. Translation: BAD99023.1 .
RefSeqi NP_001020003.1. NM_001024832.1.
UniGenei Gga.6002.

3D structure databases

ProteinModelPortali Q4W5Z4.
SMRi Q4W5Z4. Positions 248-389, 592-877.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000006352.

Protein family/group databases

REBASEi 11753. M.GgaDnmt3AP.

Proteomic databases

PaxDbi Q4W5Z4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 421991.
KEGGi gga:421991.

Organism-specific databases

CTDi 1788.

Phylogenomic databases

eggNOGi NOG70699.
HOVERGENi HBG051381.
KOi K17398.
PhylomeDBi Q4W5Z4.

Miscellaneous databases

NextBioi 20824684.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025766. ADD.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025811. C5_MeTrfase_3.
IPR000313. PWWP_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF00145. DNA_methylase. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view ]
SMARTi SM00293. PWWP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51533. ADD. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50812. PWWP. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting."
    Yokomine T., Hata K., Tsudzuki M., Sasaki H.
    Cytogenet. Genome Res. 113:75-80(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDNM3A_CHICK
AccessioniPrimary (citable) accession number: Q4W5Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2005
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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