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Q4W5Z4

- DNM3A_CHICK

UniProt

Q4W5Z4 - DNM3A_CHICK

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Protein

DNA (cytosine-5)-methyltransferase 3A

Gene

DNMT3A

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei629 – 6291S-adenosyl-L-methionineBy similarity
Active sitei675 – 6751PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri458 – 48831GATA-type; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 55557PHD-type; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB
  2. DNA binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. C-5 methylation of cytosine Source: GOC
  2. chromatin modification Source: UniProtKB-KW
  3. DNA methylation Source: UniProtKB
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Protein family/group databases

REBASEi11753. M.GgaDnmt3AP.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase 3A (EC:2.1.1.37)
Short name:
Dnmt3a
Gene namesi
Name:DNMT3A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. euchromatin Source: UniProtKB
  3. nuclear matrix Source: UniProtKB
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 877877DNA (cytosine-5)-methyltransferase 3APRO_0000313031Add
BLAST

Proteomic databases

PaxDbiQ4W5Z4.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006352.

Structurei

3D structure databases

ProteinModelPortaliQ4W5Z4.
SMRiQ4W5Z4. Positions 248-389, 592-877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini226 – 28459PWWPPROSITE-ProRule annotationAdd
BLAST
Domaini447 – 579133ADDPROSITE-ProRule annotationAdd
BLAST
Domaini599 – 877279SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni606 – 6105S-adenosyl-L-methionine bindingBy similarity
Regioni651 – 6533S-adenosyl-L-methionine bindingBy similarity
Regioni856 – 8583S-adenosyl-L-methionine bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi448 – 49649Cys-richAdd
BLAST

Domaini

The PWWP domain is essential for targeting to pericentric heterochromatin.

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 ADD domain.PROSITE-ProRule annotation
Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
Contains 1 PWWP domain.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri458 – 48831GATA-type; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri499 – 55557PHD-type; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG70699.
HOVERGENiHBG051381.
InParanoidiQ4W5Z4.
KOiK17398.
PhylomeDBiQ4W5Z4.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025766. ADD.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025811. C5_MeTrfase_3.
IPR000313. PWWP_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF00145. DNA_methylase. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51533. ADD. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50812. PWWP. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4W5Z4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVESSDTPKD TAAVPKCPPP CPEASPAEPL PNGDLEADGA QWKGTEEGGA
60 70 80 90 100
SPKSGRPEED ETESLADGET GRALENGRCT PKEGLDAPAD EGELAPSDPQ
110 120 130 140 150
KKRGRRKLLE ATEKSKEEKE ENNFDSLKME GSRGRLRGGL GWESSLRQRP
160 170 180 190 200
MQRHTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NVVEETPRAE
210 220 230 240 250
PQKEEEASPP ASQQPTDPAS PNVATTPEPV VADAVDKNTS KSADDEPEYE
260 270 280 290 300
DGRGLGIGEL VWGKLRGFSW WPGRIVSWWM TGRSRAAEGT RWVMWFGDGK
310 320 330 340 350
FSVVCVEKLL PLSSFSSAFH QATYNKQPMY RKAIYEVLQV ASSRAGKIFP
360 370 380 390 400
ACPENDETDT SKVVEIQNKQ MIEWALGGFQ PSGPKGLEPP EEERNPYKEV
410 420 430 440 450
YTEMWVEPEA AAYAPPPPAK KPRKSTTEKP KVKEIIDERT RERLVYEVRQ
460 470 480 490 500
KCRNIEDICI SCGSLNVTLE HPLFIGGMCQ NCKNCFLECA YQYDDDGYQS
510 520 530 540 550
YCTICCGGRE VLMCGNNNCC RCFCVECVDL LVGPGAAQAA IKEDPWNCYM
560 570 580 590 600
CGHKGVYGLL RRREDWPSRL QMFFANNHDQ EFDPPKVYPP VPAEKRKPIR
610 620 630 640 650
VLSLFDGIAT GLLVLKDLGI QVDRYIASEV CEDSITVGMV RHQGKIMYVG
660 670 680 690 700
DVRNVTQKHI QEWGPFDLVI GGSPCNDLSI VNPARKGLYE GTGRLFFEFY
710 720 730 740 750
RLLHEARPKE GDDRPFFWLF ENVVAMGVSD KRDISRFLES NPVMIDAKEV
760 770 780 790 800
SAAHRARYFW GNLPGMNRPL ASTVNDKLEL QECLEHGRIA KFSKVRTITT
810 820 830 840 850
RSNSIKQGKD QHFPVFMNEK EDILWCTEME RVFGFPVHYT DVSNMSRLAR
860 870
QRLLGRSWSV PVIRHLFAPL KEYFACV
Length:877
Mass (Da):98,944
Last modified:July 5, 2005 - v1
Checksum:iFC7131DA1D40F84F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB214886 mRNA. Translation: BAD99023.1.
RefSeqiNP_001020003.1. NM_001024832.1.
UniGeneiGga.6002.

Genome annotation databases

GeneIDi421991.
KEGGigga:421991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB214886 mRNA. Translation: BAD99023.1 .
RefSeqi NP_001020003.1. NM_001024832.1.
UniGenei Gga.6002.

3D structure databases

ProteinModelPortali Q4W5Z4.
SMRi Q4W5Z4. Positions 248-389, 592-877.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000006352.

Protein family/group databases

REBASEi 11753. M.GgaDnmt3AP.

Proteomic databases

PaxDbi Q4W5Z4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 421991.
KEGGi gga:421991.

Organism-specific databases

CTDi 1788.

Phylogenomic databases

eggNOGi NOG70699.
HOVERGENi HBG051381.
InParanoidi Q4W5Z4.
KOi K17398.
PhylomeDBi Q4W5Z4.

Miscellaneous databases

NextBioi 20824684.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025766. ADD.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025811. C5_MeTrfase_3.
IPR000313. PWWP_dom.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF00145. DNA_methylase. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view ]
SMARTi SM00293. PWWP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51533. ADD. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50812. PWWP. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting."
    Yokomine T., Hata K., Tsudzuki M., Sasaki H.
    Cytogenet. Genome Res. 113:75-80(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDNM3A_CHICK
AccessioniPrimary (citable) accession number: Q4W5Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3