Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q4W5Z4 (DNM3A_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA (cytosine-5)-methyltransferase 3A

Short name=Dnmt3a
EC=2.1.1.37
Gene names
Name:DNMT3A
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length877 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Domain

The PWWP domain is essential for targeting to pericentric heterochromatin.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

Contains 1 ADD domain.

Contains 1 GATA-type zinc finger.

Contains 1 PHD-type zinc finger.

Contains 1 PWWP domain.

Contains 1 SAM-dependent MTase C5-type domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentCytoplasm
Nucleus
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
S-adenosyl-L-methionine
Zinc
   Molecular functionChromatin regulator
Methyltransferase
Repressor
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processC-5 methylation of cytosine

Inferred from sequence or structural similarity PubMed 12138111. Source: GOC

DNA methylation

Inferred from sequence or structural similarity PubMed 12138111. Source: UniProtKB

chromatin modification

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity PubMed 12138111. Source: UniProtKB

euchromatin

Inferred from sequence or structural similarity PubMed 12138111. Source: UniProtKB

nuclear matrix

Inferred from sequence or structural similarity PubMed 12138111. Source: UniProtKB

nucleus

Inferred from sequence or structural similarity PubMed 12138111. Source: UniProtKB

   Molecular_functionDNA (cytosine-5-)-methyltransferase activity

Inferred from sequence or structural similarity PubMed 12138111. Source: UniProtKB

DNA binding

Inferred from sequence or structural similarity PubMed 12138111. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 877877DNA (cytosine-5)-methyltransferase 3A
PRO_0000313031

Regions

Domain226 – 28459PWWP
Domain447 – 579133ADD
Domain599 – 877279SAM-dependent MTase C5-type
Zinc finger458 – 48831GATA-type; atypical
Zinc finger499 – 55557PHD-type; atypical
Region606 – 6105S-adenosyl-L-methionine binding By similarity
Region651 – 6533S-adenosyl-L-methionine binding By similarity
Region856 – 8583S-adenosyl-L-methionine binding By similarity
Compositional bias448 – 49649Cys-rich

Sites

Active site6751 By similarity
Binding site6291S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4W5Z4 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: FC7131DA1D40F84F

FASTA87798,944
        10         20         30         40         50         60 
MVESSDTPKD TAAVPKCPPP CPEASPAEPL PNGDLEADGA QWKGTEEGGA SPKSGRPEED 

        70         80         90        100        110        120 
ETESLADGET GRALENGRCT PKEGLDAPAD EGELAPSDPQ KKRGRRKLLE ATEKSKEEKE 

       130        140        150        160        170        180 
ENNFDSLKME GSRGRLRGGL GWESSLRQRP MQRHTFQAGD PYYISKRKRD EWLARWKREA 

       190        200        210        220        230        240 
EKKAKVIAVM NVVEETPRAE PQKEEEASPP ASQQPTDPAS PNVATTPEPV VADAVDKNTS 

       250        260        270        280        290        300 
KSADDEPEYE DGRGLGIGEL VWGKLRGFSW WPGRIVSWWM TGRSRAAEGT RWVMWFGDGK 

       310        320        330        340        350        360 
FSVVCVEKLL PLSSFSSAFH QATYNKQPMY RKAIYEVLQV ASSRAGKIFP ACPENDETDT 

       370        380        390        400        410        420 
SKVVEIQNKQ MIEWALGGFQ PSGPKGLEPP EEERNPYKEV YTEMWVEPEA AAYAPPPPAK 

       430        440        450        460        470        480 
KPRKSTTEKP KVKEIIDERT RERLVYEVRQ KCRNIEDICI SCGSLNVTLE HPLFIGGMCQ 

       490        500        510        520        530        540 
NCKNCFLECA YQYDDDGYQS YCTICCGGRE VLMCGNNNCC RCFCVECVDL LVGPGAAQAA 

       550        560        570        580        590        600 
IKEDPWNCYM CGHKGVYGLL RRREDWPSRL QMFFANNHDQ EFDPPKVYPP VPAEKRKPIR 

       610        620        630        640        650        660 
VLSLFDGIAT GLLVLKDLGI QVDRYIASEV CEDSITVGMV RHQGKIMYVG DVRNVTQKHI 

       670        680        690        700        710        720 
QEWGPFDLVI GGSPCNDLSI VNPARKGLYE GTGRLFFEFY RLLHEARPKE GDDRPFFWLF 

       730        740        750        760        770        780 
ENVVAMGVSD KRDISRFLES NPVMIDAKEV SAAHRARYFW GNLPGMNRPL ASTVNDKLEL 

       790        800        810        820        830        840 
QECLEHGRIA KFSKVRTITT RSNSIKQGKD QHFPVFMNEK EDILWCTEME RVFGFPVHYT 

       850        860        870 
DVSNMSRLAR QRLLGRSWSV PVIRHLFAPL KEYFACV 

« Hide

References

[1]"Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting."
Yokomine T., Hata K., Tsudzuki M., Sasaki H.
Cytogenet. Genome Res. 113:75-80(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB214886 mRNA. Translation: BAD99023.1.
RefSeqNP_001020003.1. NM_001024832.1.
UniGeneGga.6002.

3D structure databases

ProteinModelPortalQ4W5Z4.
SMRQ4W5Z4. Positions 248-389, 592-877.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000006352.

Protein family/group databases

REBASE11753. M.GgaDnmt3AP.

Proteomic databases

PaxDbQ4W5Z4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID421991.
KEGGgga:421991.

Organism-specific databases

CTD1788.

Phylogenomic databases

eggNOGNOG70699.
HOVERGENHBG051381.
KOK17398.
PhylomeDBQ4W5Z4.

Family and domain databases

InterProIPR025766. ADD.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR025811. C5_MeTrfase_3.
IPR000313. PWWP_dom.
[Graphical view]
PfamPF00145. DNA_methylase. 1 hit.
PF00855. PWWP. 1 hit.
[Graphical view]
SMARTSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEPS51533. ADD. 1 hit.
PS00094. C5_MTASE_1. 1 hit.
PS50812. PWWP. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20824684.

Entry information

Entry nameDNM3A_CHICK
AccessionPrimary (citable) accession number: Q4W5Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families