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Q4W5Z4

- DNM3A_CHICK

UniProt

Q4W5Z4 - DNM3A_CHICK

Protein

DNA (cytosine-5)-methyltransferase 3A

Gene

DNMT3A

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei629 – 6291S-adenosyl-L-methionineBy similarity
    Active sitei675 – 6751PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri458 – 48831GATA-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri499 – 55557PHD-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB
    2. DNA binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. C-5 methylation of cytosine Source: GOC
    2. chromatin modification Source: UniProtKB-KW
    3. DNA methylation Source: UniProtKB
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Protein family/group databases

    REBASEi11753. M.GgaDnmt3AP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA (cytosine-5)-methyltransferase 3A (EC:2.1.1.37)
    Short name:
    Dnmt3a
    Gene namesi
    Name:DNMT3A
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. euchromatin Source: UniProtKB
    3. nuclear matrix Source: UniProtKB
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 877877DNA (cytosine-5)-methyltransferase 3APRO_0000313031Add
    BLAST

    Proteomic databases

    PaxDbiQ4W5Z4.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000006352.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4W5Z4.
    SMRiQ4W5Z4. Positions 248-389, 592-877.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini226 – 28459PWWPPROSITE-ProRule annotationAdd
    BLAST
    Domaini447 – 579133ADDPROSITE-ProRule annotationAdd
    BLAST
    Domaini599 – 877279SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni606 – 6105S-adenosyl-L-methionine bindingBy similarity
    Regioni651 – 6533S-adenosyl-L-methionine bindingBy similarity
    Regioni856 – 8583S-adenosyl-L-methionine bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi448 – 49649Cys-richAdd
    BLAST

    Domaini

    The PWWP domain is essential for targeting to pericentric heterochromatin.

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 1 ADD domain.PROSITE-ProRule annotation
    Contains 1 GATA-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PWWP domain.PROSITE-ProRule annotation
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri458 – 48831GATA-type; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri499 – 55557PHD-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG70699.
    HOVERGENiHBG051381.
    KOiK17398.
    PhylomeDBiQ4W5Z4.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025766. ADD.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR025811. C5_MeTrfase_3.
    IPR000313. PWWP_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF00145. DNA_methylase. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view]
    SMARTiSM00293. PWWP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51533. ADD. 1 hit.
    PS00094. C5_MTASE_1. 1 hit.
    PS50812. PWWP. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4W5Z4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVESSDTPKD TAAVPKCPPP CPEASPAEPL PNGDLEADGA QWKGTEEGGA    50
    SPKSGRPEED ETESLADGET GRALENGRCT PKEGLDAPAD EGELAPSDPQ 100
    KKRGRRKLLE ATEKSKEEKE ENNFDSLKME GSRGRLRGGL GWESSLRQRP 150
    MQRHTFQAGD PYYISKRKRD EWLARWKREA EKKAKVIAVM NVVEETPRAE 200
    PQKEEEASPP ASQQPTDPAS PNVATTPEPV VADAVDKNTS KSADDEPEYE 250
    DGRGLGIGEL VWGKLRGFSW WPGRIVSWWM TGRSRAAEGT RWVMWFGDGK 300
    FSVVCVEKLL PLSSFSSAFH QATYNKQPMY RKAIYEVLQV ASSRAGKIFP 350
    ACPENDETDT SKVVEIQNKQ MIEWALGGFQ PSGPKGLEPP EEERNPYKEV 400
    YTEMWVEPEA AAYAPPPPAK KPRKSTTEKP KVKEIIDERT RERLVYEVRQ 450
    KCRNIEDICI SCGSLNVTLE HPLFIGGMCQ NCKNCFLECA YQYDDDGYQS 500
    YCTICCGGRE VLMCGNNNCC RCFCVECVDL LVGPGAAQAA IKEDPWNCYM 550
    CGHKGVYGLL RRREDWPSRL QMFFANNHDQ EFDPPKVYPP VPAEKRKPIR 600
    VLSLFDGIAT GLLVLKDLGI QVDRYIASEV CEDSITVGMV RHQGKIMYVG 650
    DVRNVTQKHI QEWGPFDLVI GGSPCNDLSI VNPARKGLYE GTGRLFFEFY 700
    RLLHEARPKE GDDRPFFWLF ENVVAMGVSD KRDISRFLES NPVMIDAKEV 750
    SAAHRARYFW GNLPGMNRPL ASTVNDKLEL QECLEHGRIA KFSKVRTITT 800
    RSNSIKQGKD QHFPVFMNEK EDILWCTEME RVFGFPVHYT DVSNMSRLAR 850
    QRLLGRSWSV PVIRHLFAPL KEYFACV 877
    Length:877
    Mass (Da):98,944
    Last modified:July 5, 2005 - v1
    Checksum:iFC7131DA1D40F84F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB214886 mRNA. Translation: BAD99023.1.
    RefSeqiNP_001020003.1. NM_001024832.1.
    UniGeneiGga.6002.

    Genome annotation databases

    GeneIDi421991.
    KEGGigga:421991.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB214886 mRNA. Translation: BAD99023.1 .
    RefSeqi NP_001020003.1. NM_001024832.1.
    UniGenei Gga.6002.

    3D structure databases

    ProteinModelPortali Q4W5Z4.
    SMRi Q4W5Z4. Positions 248-389, 592-877.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000006352.

    Protein family/group databases

    REBASEi 11753. M.GgaDnmt3AP.

    Proteomic databases

    PaxDbi Q4W5Z4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 421991.
    KEGGi gga:421991.

    Organism-specific databases

    CTDi 1788.

    Phylogenomic databases

    eggNOGi NOG70699.
    HOVERGENi HBG051381.
    KOi K17398.
    PhylomeDBi Q4W5Z4.

    Miscellaneous databases

    NextBioi 20824684.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025766. ADD.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR025811. C5_MeTrfase_3.
    IPR000313. PWWP_dom.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF00145. DNA_methylase. 1 hit.
    PF00855. PWWP. 1 hit.
    [Graphical view ]
    SMARTi SM00293. PWWP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51533. ADD. 1 hit.
    PS00094. C5_MTASE_1. 1 hit.
    PS50812. PWWP. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting."
      Yokomine T., Hata K., Tsudzuki M., Sasaki H.
      Cytogenet. Genome Res. 113:75-80(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiDNM3A_CHICK
    AccessioniPrimary (citable) accession number: Q4W5Z4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3