ID   Q4W5L2_HUMAN            Unreviewed;       102 AA.
AC   Q4W5L2;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   RecName: Full=Alpha-synuclein {ECO:0000256|ARBA:ARBA00017952, ECO:0000256|RuleBase:RU361225};
DE   Flags: Fragment;
GN   Name=SNCA {ECO:0000313|EMBL:AAY40956.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAY40956.1};
RN   [1] {ECO:0000313|EMBL:AAY40956.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Meyer R., Mulvaney E.;
RT   "The sequence of Homo sapiens BAC clone RP11-67M1.";
RL   Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAY40956.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Waterston R.H.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAY40956.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Waterston R.;
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAY40956.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, axon
CC       {ECO:0000256|ARBA:ARBA00004489}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the synuclein family.
CC       {ECO:0000256|ARBA:ARBA00009147, ECO:0000256|RuleBase:RU361225}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC093759; AAY40956.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4W5L2; -.
DR   PeptideAtlas; Q4W5L2; -.
DR   ChiTaRS; SNCA; human.
DR   GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0014059; P:regulation of dopamine secretion; IEA:InterPro.
DR   Gene3D; 1.10.287.700; Helix hairpin bin; 1.
DR   InterPro; IPR001058; Synuclein.
DR   InterPro; IPR002460; Synuclein_alpha.
DR   PANTHER; PTHR13820:SF5; ALPHA-SYNUCLEIN; 1.
DR   PANTHER; PTHR13820; SYNUCLEIN; 1.
DR   Pfam; PF01387; Synuclein; 1.
DR   PRINTS; PR01212; ASYNUCLEIN.
DR   PRINTS; PR01211; SYNUCLEIN.
DR   SUPFAM; SSF118375; Synuclein; 1.
PE   3: Inferred from homology;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   NON_TER         102
FT                   /evidence="ECO:0000313|EMBL:AAY40956.1"
SQ   SEQUENCE   102 AA;  10190 MW;  78D2159484F9250D CRC64;
     MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK
     EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GK
//