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Protein

Alpha-synuclein

Gene

SNCA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. arachidonic acid binding Source: Ensembl
  2. phospholipid binding Source: Ensembl

GO - Biological processi

  1. adult locomotory behavior Source: Ensembl
  2. aging Source: Ensembl
  3. behavioral response to cocaine Source: Ensembl
  4. cellular response to fibroblast growth factor stimulus Source: Ensembl
  5. cellular response to oxidative stress Source: Ensembl
  6. dopamine biosynthetic process Source: Ensembl
  7. fatty acid metabolic process Source: Ensembl
  8. long-term synaptic potentiation Source: Ensembl
  9. microglial cell activation Source: Ensembl
  10. mitochondrial ATP synthesis coupled electron transport Source: Ensembl
  11. mitochondrial membrane organization Source: Ensembl
  12. negative regulation of dopamine metabolic process Source: Ensembl
  13. negative regulation of neuron apoptotic process Source: Ensembl
  14. negative regulation of protein phosphorylation Source: Ensembl
  15. neutral lipid metabolic process Source: Ensembl
  16. phospholipid metabolic process Source: Ensembl
  17. positive regulation of neurotransmitter secretion Source: Ensembl
  18. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  19. regulation of acyl-CoA biosynthetic process Source: Ensembl
  20. regulation of dopamine secretion Source: Ensembl
  21. regulation of excitatory postsynaptic membrane potential Source: Ensembl
  22. regulation of glutamate secretion Source: Ensembl
  23. regulation of locomotion Source: Ensembl
  24. regulation of long-term neuronal synaptic plasticity Source: Ensembl
  25. regulation of macrophage activation Source: Ensembl
  26. regulation of reactive oxygen species metabolic process Source: Ensembl
  27. response to drug Source: Ensembl
  28. synapse organization Source: Ensembl
  29. synaptic transmission, dopaminergic Source: Ensembl
  30. synaptic vesicle endocytosis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synucleinUniRule annotation
Gene namesi
Name:SNCAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle membrane Source: Ensembl
  2. cytoskeleton Source: Ensembl
  3. cytosol Source: Ensembl
  4. Golgi apparatus Source: Ensembl
  5. growth cone Source: Ensembl
  6. inclusion body Source: Ensembl
  7. mitochondrion Source: Ensembl
  8. nuclear outer membrane Source: Ensembl
  9. plasma membrane Source: Ensembl
  10. ribosome Source: Ensembl
  11. rough endoplasmic reticulum Source: Ensembl
  12. synaptic vesicle Source: Ensembl
  13. terminal bouton Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ4W5L2.

Expressioni

Gene expression databases

BgeeiQ4W5L2.
ExpressionAtlasiQ4W5L2. baseline and differential.

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the synuclein family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000008691.
HOVERGENiHBG000481.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.

Sequencei

Sequence statusi: Fragment.

Q4W5L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60 70 80 90 100
GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL

GK
Length:102
Mass (Da):10,190
Last modified:July 5, 2005 - v1
Checksum:i78D2159484F9250D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei102 – 1021Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093759 Genomic DNA. Translation: AAY40956.1.
UniGeneiHs.21374.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093759 Genomic DNA. Translation: AAY40956.1.
UniGeneiHs.21374.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ4W5L2.

Proteomic databases

PRIDEiQ4W5L2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000008691.
HOVERGENiHBG000481.

Miscellaneous databases

ChiTaRSiSNCA. human.

Gene expression databases

BgeeiQ4W5L2.
ExpressionAtlasiQ4W5L2. baseline and differential.

Family and domain databases

Gene3Di1.10.287.700. 1 hit.
InterProiIPR001058. Synuclein.
IPR002460. Synuclein_alpha.
[Graphical view]
PANTHERiPTHR13820. PTHR13820. 1 hit.
PfamiPF01387. Synuclein. 1 hit.
[Graphical view]
PRINTSiPR01212. ASYNUCLEIN.
PR01211. SYNUCLEIN.
ProtoNetiSearch...

Publicationsi

  1. "The sequence of Homo sapiens BAC clone RP11-67M1."
    Meyer R., Mulvaney E.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Waterston R.H.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Waterston R.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Wilson R.K.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ4W5L2_HUMAN
AccessioniPrimary (citable) accession number: Q4W5L2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 4, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.