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Q4W5L2

- Q4W5L2_HUMAN

UniProt

Q4W5L2 - Q4W5L2_HUMAN

Protein
Submitted name:

Putative uncharacterized protein SNCA

Gene

SNCA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. arachidonic acid binding Source: Ensembl
    2. phospholipid binding Source: Ensembl

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. aging Source: Ensembl
    3. behavioral response to cocaine Source: Ensembl
    4. cellular response to fibroblast growth factor stimulus Source: Ensembl
    5. cellular response to oxidative stress Source: Ensembl
    6. dopamine biosynthetic process Source: Ensembl
    7. fatty acid metabolic process Source: Ensembl
    8. long-term synaptic potentiation Source: Ensembl
    9. microglial cell activation Source: Ensembl
    10. mitochondrial ATP synthesis coupled electron transport Source: Ensembl
    11. mitochondrial membrane organization Source: Ensembl
    12. negative regulation of dopamine metabolic process Source: Ensembl
    13. negative regulation of neuron apoptotic process Source: Ensembl
    14. negative regulation of protein phosphorylation Source: Ensembl
    15. neutral lipid metabolic process Source: Ensembl
    16. phospholipid metabolic process Source: Ensembl
    17. positive regulation of neurotransmitter secretion Source: Ensembl
    18. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    19. regulation of acyl-CoA biosynthetic process Source: Ensembl
    20. regulation of dopamine secretion Source: Ensembl
    21. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    22. regulation of glutamate secretion Source: Ensembl
    23. regulation of locomotion Source: Ensembl
    24. regulation of long-term neuronal synaptic plasticity Source: Ensembl
    25. regulation of macrophage activation Source: Ensembl
    26. response to drug Source: Ensembl
    27. synapse organization Source: Ensembl
    28. synaptic transmission, dopaminergic Source: Ensembl
    29. synaptic vesicle endocytosis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized protein SNCAImported
    Gene namesi
    Name:SNCAImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: Ensembl
    2. cytoskeleton Source: Ensembl
    3. cytosol Source: Ensembl
    4. Golgi apparatus Source: Ensembl
    5. growth cone Source: Ensembl
    6. mitochondrion Source: Ensembl
    7. nuclear outer membrane Source: Ensembl
    8. plasma membrane Source: Ensembl
    9. ribosome Source: Ensembl
    10. rough endoplasmic reticulum Source: Ensembl
    11. synaptic vesicle Source: Ensembl
    12. terminal bouton Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ4W5L2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ4W5L2.
    BgeeiQ4W5L2.

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000008691.
    HOVERGENiHBG000481.

    Family and domain databases

    Gene3Di1.10.287.700. 1 hit.
    InterProiIPR001058. Synuclein.
    IPR002460. Synuclein_alpha.
    [Graphical view]
    PANTHERiPTHR13820. PTHR13820. 1 hit.
    PfamiPF01387. Synuclein. 1 hit.
    [Graphical view]
    PRINTSiPR01212. ASYNUCLEIN.
    PR01211. SYNUCLEIN.

    Sequencei

    Sequence statusi: Fragment.

    Q4W5L2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH    50
    GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL 100
    GK 102
    Length:102
    Mass (Da):10,190
    Last modified:July 5, 2005 - v1
    Checksum:i78D2159484F9250D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei102 – 1021Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093759 Genomic DNA. Translation: AAY40956.1.
    UniGeneiHs.21374.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093759 Genomic DNA. Translation: AAY40956.1 .
    UniGenei Hs.21374.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q4W5L2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000008691.
    HOVERGENi HBG000481.

    Miscellaneous databases

    ChiTaRSi SNCA. human.

    Gene expression databases

    ArrayExpressi Q4W5L2.
    Bgeei Q4W5L2.

    Family and domain databases

    Gene3Di 1.10.287.700. 1 hit.
    InterProi IPR001058. Synuclein.
    IPR002460. Synuclein_alpha.
    [Graphical view ]
    PANTHERi PTHR13820. PTHR13820. 1 hit.
    Pfami PF01387. Synuclein. 1 hit.
    [Graphical view ]
    PRINTSi PR01212. ASYNUCLEIN.
    PR01211. SYNUCLEIN.
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of Homo sapiens BAC clone RP11-67M1."
      Meyer R., Mulvaney E.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Waterston R.H.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Waterston R.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. Wilson R.K.
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ4W5L2_HUMAN
    AccessioniPrimary (citable) accession number: Q4W5L2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.