Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4W5G0

- TIGD2_HUMAN

UniProt

Q4W5G0 - TIGD2_HUMAN

Protein

Tigger transposable element-derived protein 2

Gene

TIGD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi28 – 4821H-T-H motifBy similarityAdd
    BLAST
    DNA bindingi100 – 13233H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tigger transposable element-derived protein 2
    Gene namesi
    Name:TIGD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:18333. TIGD2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38526.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Tigger transposable element-derived protein 2PRO_0000271088Add
    BLAST

    Proteomic databases

    MaxQBiQ4W5G0.
    PaxDbiQ4W5G0.
    PRIDEiQ4W5G0.

    PTM databases

    PhosphoSiteiQ4W5G0.

    Expressioni

    Gene expression databases

    BgeeiQ4W5G0.
    CleanExiHS_TIGD2.
    GenevestigatoriQ4W5G0.

    Organism-specific databases

    HPAiHPA054844.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000317170.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4W5G0.
    SMRiQ4W5G0. Positions 6-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5252HTH psq-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini67 – 13973HTH CENPB-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini168 – 385218DDEAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DDE domain.Curated
    Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG71546.
    HOGENOMiHOG000130798.
    HOVERGENiHBG101551.
    InParanoidiQ4W5G0.
    OMAiSGTICAK.
    OrthoDBiEOG7GBFWK.
    PhylomeDBiQ4W5G0.
    TreeFamiTF101131.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007889. HTH_Psq.
    [Graphical view]
    PfamiPF04218. CENP-B_N. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view]
    SMARTiSM00674. CENPB. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS51253. HTH_CENPB. 1 hit.
    PS50960. HTH_PSQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4W5G0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE    50
    RIINYANSSD PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT 100
    ICAKQAKFFF DALGMEGDFN ASSGWLTRFK QRHGIPKAAG KGTKLKGDET 150
    AAREFCGSFQ EFVEKENLQP EQIYGADQTG LFWKCLPSRT LTLETDQSTS 200
    GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT DLSNLPVTYY 250
    SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE 300
    EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG 350
    NDPKIFWKNL TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI 400
    DEGAILAANL ATVLQNTEEC EHVDIENIDQ WFDSRSSDSS CQVLTDSESA 450
    EDQTKAAEQK PSSKSRKTEL NPEKHISHKA ALEWTENLLD YLEQQDDMLL 500
    SDKLVLRRLR TIIRKKQKIQ NNKNH 525
    Length:525
    Mass (Da):59,623
    Last modified:July 5, 2005 - v1
    Checksum:i5FD2A8B1765D1001
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti475 – 4751H → R.
    Corresponds to variant rs2280099 [ dbSNP | Ensembl ].
    VAR_053036

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104785 Genomic DNA. Translation: AAY40951.1.
    CCDSiCCDS3633.1.
    RefSeqiNP_663761.1. NM_145715.2.
    UniGeneiHs.58924.

    Genome annotation databases

    EnsembliENST00000317005; ENSP00000317170; ENSG00000180346.
    GeneIDi166815.
    KEGGihsa:166815.
    UCSCiuc003hsk.3. human.

    Polymorphism databases

    DMDMi74754171.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104785 Genomic DNA. Translation: AAY40951.1 .
    CCDSi CCDS3633.1.
    RefSeqi NP_663761.1. NM_145715.2.
    UniGenei Hs.58924.

    3D structure databases

    ProteinModelPortali Q4W5G0.
    SMRi Q4W5G0. Positions 6-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000317170.

    PTM databases

    PhosphoSitei Q4W5G0.

    Polymorphism databases

    DMDMi 74754171.

    Proteomic databases

    MaxQBi Q4W5G0.
    PaxDbi Q4W5G0.
    PRIDEi Q4W5G0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317005 ; ENSP00000317170 ; ENSG00000180346 .
    GeneIDi 166815.
    KEGGi hsa:166815.
    UCSCi uc003hsk.3. human.

    Organism-specific databases

    CTDi 166815.
    GeneCardsi GC04P090033.
    HGNCi HGNC:18333. TIGD2.
    HPAi HPA054844.
    MIMi 612973. gene.
    neXtProti NX_Q4W5G0.
    PharmGKBi PA38526.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71546.
    HOGENOMi HOG000130798.
    HOVERGENi HBG101551.
    InParanoidi Q4W5G0.
    OMAi SGTICAK.
    OrthoDBi EOG7GBFWK.
    PhylomeDBi Q4W5G0.
    TreeFami TF101131.

    Miscellaneous databases

    GenomeRNAii 166815.
    NextBioi 88627.
    PROi Q4W5G0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q4W5G0.
    CleanExi HS_TIGD2.
    Genevestigatori Q4W5G0.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
    IPR009057. Homeodomain-like.
    IPR006600. HTH_CenpB_DNA-bd_dom.
    IPR007889. HTH_Psq.
    [Graphical view ]
    Pfami PF04218. CENP-B_N. 1 hit.
    PF03184. DDE_1. 1 hit.
    PF03221. HTH_Tnp_Tc5. 1 hit.
    [Graphical view ]
    SMARTi SM00674. CENPB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS51253. HTH_CENPB. 1 hit.
    PS50960. HTH_PSQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiTIGD2_HUMAN
    AccessioniPrimary (citable) accession number: Q4W5G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3