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Q4W5G0

- TIGD2_HUMAN

UniProt

Q4W5G0 - TIGD2_HUMAN

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Protein

Tigger transposable element-derived protein 2

Gene
TIGD2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi28 – 4821H-T-H motif By similarityAdd
BLAST
DNA bindingi100 – 13233H-T-H motif By similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 2
Gene namesi
Name:TIGD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:18333. TIGD2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Tigger transposable element-derived protein 2PRO_0000271088Add
BLAST

Proteomic databases

MaxQBiQ4W5G0.
PaxDbiQ4W5G0.
PRIDEiQ4W5G0.

PTM databases

PhosphoSiteiQ4W5G0.

Expressioni

Gene expression databases

BgeeiQ4W5G0.
CleanExiHS_TIGD2.
GenevestigatoriQ4W5G0.

Organism-specific databases

HPAiHPA054844.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317170.

Structurei

3D structure databases

ProteinModelPortaliQ4W5G0.
SMRiQ4W5G0. Positions 6-132.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5252HTH psq-typeAdd
BLAST
Domaini67 – 13973HTH CENPB-typeAdd
BLAST
Domaini168 – 385218DDEAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.

Phylogenomic databases

eggNOGiNOG71546.
HOGENOMiHOG000130798.
HOVERGENiHBG101551.
InParanoidiQ4W5G0.
OMAiSGTICAK.
OrthoDBiEOG7GBFWK.
PhylomeDBiQ4W5G0.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4W5G0-1 [UniParc]FASTAAdd to Basket

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MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE    50
RIINYANSSD PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT 100
ICAKQAKFFF DALGMEGDFN ASSGWLTRFK QRHGIPKAAG KGTKLKGDET 150
AAREFCGSFQ EFVEKENLQP EQIYGADQTG LFWKCLPSRT LTLETDQSTS 200
GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT DLSNLPVTYY 250
SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE 300
EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG 350
NDPKIFWKNL TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI 400
DEGAILAANL ATVLQNTEEC EHVDIENIDQ WFDSRSSDSS CQVLTDSESA 450
EDQTKAAEQK PSSKSRKTEL NPEKHISHKA ALEWTENLLD YLEQQDDMLL 500
SDKLVLRRLR TIIRKKQKIQ NNKNH 525
Length:525
Mass (Da):59,623
Last modified:July 5, 2005 - v1
Checksum:i5FD2A8B1765D1001
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti475 – 4751H → R.
Corresponds to variant rs2280099 [ dbSNP | Ensembl ].
VAR_053036

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104785 Genomic DNA. Translation: AAY40951.1.
CCDSiCCDS3633.1.
RefSeqiNP_663761.1. NM_145715.2.
UniGeneiHs.58924.

Genome annotation databases

EnsembliENST00000317005; ENSP00000317170; ENSG00000180346.
GeneIDi166815.
KEGGihsa:166815.
UCSCiuc003hsk.3. human.

Polymorphism databases

DMDMi74754171.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104785 Genomic DNA. Translation: AAY40951.1 .
CCDSi CCDS3633.1.
RefSeqi NP_663761.1. NM_145715.2.
UniGenei Hs.58924.

3D structure databases

ProteinModelPortali Q4W5G0.
SMRi Q4W5G0. Positions 6-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000317170.

PTM databases

PhosphoSitei Q4W5G0.

Polymorphism databases

DMDMi 74754171.

Proteomic databases

MaxQBi Q4W5G0.
PaxDbi Q4W5G0.
PRIDEi Q4W5G0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317005 ; ENSP00000317170 ; ENSG00000180346 .
GeneIDi 166815.
KEGGi hsa:166815.
UCSCi uc003hsk.3. human.

Organism-specific databases

CTDi 166815.
GeneCardsi GC04P090033.
HGNCi HGNC:18333. TIGD2.
HPAi HPA054844.
MIMi 612973. gene.
neXtProti NX_Q4W5G0.
PharmGKBi PA38526.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG71546.
HOGENOMi HOG000130798.
HOVERGENi HBG101551.
InParanoidi Q4W5G0.
OMAi SGTICAK.
OrthoDBi EOG7GBFWK.
PhylomeDBi Q4W5G0.
TreeFami TF101131.

Miscellaneous databases

GenomeRNAii 166815.
NextBioi 88627.
PROi Q4W5G0.
SOURCEi Search...

Gene expression databases

Bgeei Q4W5G0.
CleanExi HS_TIGD2.
Genevestigatori Q4W5G0.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
InterProi IPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view ]
Pfami PF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view ]
SMARTi SM00674. CENPB. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTIGD2_HUMAN
AccessioniPrimary (citable) accession number: Q4W5G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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