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Protein

Tigger transposable element-derived protein 2

Gene

TIGD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi28 – 4821H-T-H motifBy similarityAdd
BLAST
DNA bindingi100 – 13233H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 2
Gene namesi
Name:TIGD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:18333. TIGD2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Tigger transposable element-derived protein 2PRO_0000271088Add
BLAST

Proteomic databases

MaxQBiQ4W5G0.
PaxDbiQ4W5G0.
PRIDEiQ4W5G0.

PTM databases

PhosphoSiteiQ4W5G0.

Expressioni

Gene expression databases

BgeeiQ4W5G0.
CleanExiHS_TIGD2.
ExpressionAtlasiQ4W5G0. baseline and differential.
GenevestigatoriQ4W5G0.

Organism-specific databases

HPAiHPA054844.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317170.

Structurei

3D structure databases

ProteinModelPortaliQ4W5G0.
SMRiQ4W5G0. Positions 6-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5252HTH psq-typePROSITE-ProRule annotationAdd
BLAST
Domaini67 – 13973HTH CENPB-typePROSITE-ProRule annotationAdd
BLAST
Domaini168 – 385218DDEAdd
BLAST

Sequence similaritiesi

Contains 1 DDE domain.Curated
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG71546.
HOGENOMiHOG000130798.
HOVERGENiHBG101551.
InParanoidiQ4W5G0.
OMAiSGTICAK.
OrthoDBiEOG7GBFWK.
PhylomeDBiQ4W5G0.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4W5G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE
60 70 80 90 100
RIINYANSSD PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT
110 120 130 140 150
ICAKQAKFFF DALGMEGDFN ASSGWLTRFK QRHGIPKAAG KGTKLKGDET
160 170 180 190 200
AAREFCGSFQ EFVEKENLQP EQIYGADQTG LFWKCLPSRT LTLETDQSTS
210 220 230 240 250
GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT DLSNLPVTYY
260 270 280 290 300
SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE
310 320 330 340 350
EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG
360 370 380 390 400
NDPKIFWKNL TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI
410 420 430 440 450
DEGAILAANL ATVLQNTEEC EHVDIENIDQ WFDSRSSDSS CQVLTDSESA
460 470 480 490 500
EDQTKAAEQK PSSKSRKTEL NPEKHISHKA ALEWTENLLD YLEQQDDMLL
510 520
SDKLVLRRLR TIIRKKQKIQ NNKNH
Length:525
Mass (Da):59,623
Last modified:July 5, 2005 - v1
Checksum:i5FD2A8B1765D1001
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti475 – 4751H → R.
Corresponds to variant rs2280099 [ dbSNP | Ensembl ].
VAR_053036

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104785 Genomic DNA. Translation: AAY40951.1.
CCDSiCCDS3633.1.
RefSeqiNP_663761.1. NM_145715.2.
UniGeneiHs.58924.

Genome annotation databases

EnsembliENST00000317005; ENSP00000317170; ENSG00000180346.
GeneIDi166815.
KEGGihsa:166815.
UCSCiuc003hsk.3. human.

Polymorphism databases

DMDMi74754171.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104785 Genomic DNA. Translation: AAY40951.1.
CCDSiCCDS3633.1.
RefSeqiNP_663761.1. NM_145715.2.
UniGeneiHs.58924.

3D structure databases

ProteinModelPortaliQ4W5G0.
SMRiQ4W5G0. Positions 6-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317170.

PTM databases

PhosphoSiteiQ4W5G0.

Polymorphism databases

DMDMi74754171.

Proteomic databases

MaxQBiQ4W5G0.
PaxDbiQ4W5G0.
PRIDEiQ4W5G0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317005; ENSP00000317170; ENSG00000180346.
GeneIDi166815.
KEGGihsa:166815.
UCSCiuc003hsk.3. human.

Organism-specific databases

CTDi166815.
GeneCardsiGC04P090033.
HGNCiHGNC:18333. TIGD2.
HPAiHPA054844.
MIMi612973. gene.
neXtProtiNX_Q4W5G0.
PharmGKBiPA38526.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG71546.
HOGENOMiHOG000130798.
HOVERGENiHBG101551.
InParanoidiQ4W5G0.
OMAiSGTICAK.
OrthoDBiEOG7GBFWK.
PhylomeDBiQ4W5G0.
TreeFamiTF101131.

Miscellaneous databases

GenomeRNAii166815.
NextBioi88627.
PROiQ4W5G0.
SOURCEiSearch...

Gene expression databases

BgeeiQ4W5G0.
CleanExiHS_TIGD2.
ExpressionAtlasiQ4W5G0. baseline and differential.
GenevestigatoriQ4W5G0.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiTIGD2_HUMAN
AccessioniPrimary (citable) accession number: Q4W5G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.