Q4W5G0 (TIGD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tigger transposable element-derived protein 2

Gene names

Name:

TIGD2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	525 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the tigger transposable element derived protein family. Contains 1 DDE domain. Contains 1 HTH CENPB-type DNA-binding domain. Contains 1 HTH psq-type DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 525	525	Tigger transposable element-derived protein 2		PRO_0000271088
Regions
	Domain	1 – 52	52	HTH psq-type
	Domain	67 – 139	73	HTH CENPB-type
	Domain	168 – 385	218	DDE
	DNA binding	28 – 48	21	H-T-H motif By similarity
	DNA binding	100 – 132	33	H-T-H motif By similarity
Natural variations
	Natural variant	475	1	H → R. Corresponds to variant rs2280099 [ dbSNP | Ensembl ].		VAR_053036

Sequences

	Sequence		Length	Mass (Da)
	Q4W5G0 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 5FD2A8B1765D1001	FASTA	525	59,623
	10 20 30 40 50 60 MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE RIINYANSSD 70 80 90 100 110 120 PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT ICAKQAKFFF DALGMEGDFN 130 140 150 160 170 180 ASSGWLTRFK QRHGIPKAAG KGTKLKGDET AAREFCGSFQ EFVEKENLQP EQIYGADQTG 190 200 210 220 230 240 LFWKCLPSRT LTLETDQSTS GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT 250 260 270 280 290 300 DLSNLPVTYY SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE 310 320 330 340 350 360 EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG NDPKIFWKNL 370 380 390 400 410 420 TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI DEGAILAANL ATVLQNTEEC 430 440 450 460 470 480 EHVDIENIDQ WFDSRSSDSS CQVLTDSESA EDQTKAAEQK PSSKSRKTEL NPEKHISHKA 490 500 510 520 ALEWTENLLD YLEQQDDMLL SDKLVLRRLR TIIRKKQKIQ NNKNH

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC104785 Genomic DNA. Translation: AAY40951.1.
IPI	IPI00170549.
RefSeq	NP_663761.1. NM_145715.2.
UniGene	Hs.58924.
3D structure databases
HSSP	HSSP built from PDB template 1HLV based on UniProtKB P07199.
ProteinModelPortal	Q4W5G0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000317170.
PTM databases
PhosphoSite	Q4W5G0.
Polymorphism databases
DMDM	74754171.
Proteomic databases
PaxDb	Q4W5G0.
PRIDE	Q4W5G0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317005; ENSP00000317170; ENSG00000180346.
GeneID	166815.
KEGG	hsa:166815.
UCSC	uc003hsk.3. human.
Organism-specific databases
CTD	166815.
GeneCards	GC04P090033.
HGNC	HGNC:18333. TIGD2.
HPA	HPA054844.
MIM	612973. gene.
neXtProt	NX_Q4W5G0.
PharmGKB	PA38526.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG71546.
HOGENOM	HOG000130798.
HOVERGEN	HBG101551.
InParanoid	Q4W5G0.
OMA	DQTGLFW.
OrthoDB	EOG444KK2.
PhylomeDB	Q4W5G0.
Gene expression databases
Bgee	Q4W5G0.
CleanEx	HS_TIGD2.
Genevestigator	Q4W5G0.
Family and domain databases
Gene3D	1.10.10.60. 2 hits.
InterPro	IPR004875. DDE_SF_endonuclease_CENPB-like. IPR009057. Homeodomain-like. IPR006600. HTH_CenpB_DNA-bd_dom. IPR007889. HTH_Psq. [Graphical view]
Pfam	PF04218. CENP-B_N. 1 hit. PF03184. DDE_1. 1 hit. PF03221. HTH_Tnp_Tc5. 1 hit. [Graphical view]
SMART	SM00674. CENPB. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits.
PROSITE	PS51253. HTH_CENPB. 1 hit. PS50960. HTH_PSQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	166815.
NextBio	88627.
SOURCE	Search...

Entry information

Entry name

TIGD2_HUMAN

Accession

Primary (citable) accession number: Q4W5G0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.