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Q4W5G0 (TIGD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tigger transposable element-derived protein 2
Gene names
Name:TIGD2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the tigger transposable element derived protein family.

Contains 1 DDE domain.

Contains 1 HTH CENPB-type DNA-binding domain.

Contains 1 HTH psq-type DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 525525Tigger transposable element-derived protein 2
PRO_0000271088

Regions

Domain1 – 5252HTH psq-type
Domain67 – 13973HTH CENPB-type
Domain168 – 385218DDE
DNA binding28 – 4821H-T-H motif By similarity
DNA binding100 – 13233H-T-H motif By similarity

Natural variations

Natural variant4751H → R.
Corresponds to variant rs2280099 [ dbSNP | Ensembl ].
VAR_053036

Sequences

Sequence LengthMass (Da)Tools
Q4W5G0 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 5FD2A8B1765D1001

FASTA52559,623
        10         20         30         40         50         60 
MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE RIINYANSSD 

        70         80         90        100        110        120 
PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT ICAKQAKFFF DALGMEGDFN 

       130        140        150        160        170        180 
ASSGWLTRFK QRHGIPKAAG KGTKLKGDET AAREFCGSFQ EFVEKENLQP EQIYGADQTG 

       190        200        210        220        230        240 
LFWKCLPSRT LTLETDQSTS GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT 

       250        260        270        280        290        300 
DLSNLPVTYY SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE 

       310        320        330        340        350        360 
EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG NDPKIFWKNL 

       370        380        390        400        410        420 
TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI DEGAILAANL ATVLQNTEEC 

       430        440        450        460        470        480 
EHVDIENIDQ WFDSRSSDSS CQVLTDSESA EDQTKAAEQK PSSKSRKTEL NPEKHISHKA 

       490        500        510        520 
ALEWTENLLD YLEQQDDMLL SDKLVLRRLR TIIRKKQKIQ NNKNH 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC104785 Genomic DNA. Translation: AAY40951.1.
RefSeqNP_663761.1. NM_145715.2.
UniGeneHs.58924.

3D structure databases

ProteinModelPortalQ4W5G0.
SMRQ4W5G0. Positions 6-132.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000317170.

PTM databases

PhosphoSiteQ4W5G0.

Polymorphism databases

DMDM74754171.

Proteomic databases

PaxDbQ4W5G0.
PRIDEQ4W5G0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317005; ENSP00000317170; ENSG00000180346.
GeneID166815.
KEGGhsa:166815.
UCSCuc003hsk.3. human.

Organism-specific databases

CTD166815.
GeneCardsGC04P090033.
HGNCHGNC:18333. TIGD2.
HPAHPA054844.
MIM612973. gene.
neXtProtNX_Q4W5G0.
PharmGKBPA38526.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG71546.
HOGENOMHOG000130798.
HOVERGENHBG101551.
InParanoidQ4W5G0.
OMASGTICAK.
OrthoDBEOG7GBFWK.
PhylomeDBQ4W5G0.
TreeFamTF101131.

Gene expression databases

BgeeQ4W5G0.
CleanExHS_TIGD2.
GenevestigatorQ4W5G0.

Family and domain databases

Gene3D1.10.10.60. 2 hits.
InterProIPR004875. DDE_SF_endonuclease_CENPB-like.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi166815.
NextBio88627.
PROQ4W5G0.
SOURCESearch...

Entry information

Entry nameTIGD2_HUMAN
AccessionPrimary (citable) accession number: Q4W5G0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM