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Protein
Submitted name:

Adrenergic, alpha-2C-, receptor

Gene

ADRA2C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Adrenergic, alpha-2C-, receptorImported
Gene namesi
Name:ADRA2CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000184160.7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 76HelicalSequence analysisAdd BLAST27
Transmembranei88 – 109HelicalSequence analysisAdd BLAST22
Transmembranei115 – 147HelicalSequence analysisAdd BLAST33
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Transmembranei208 – 231HelicalSequence analysisAdd BLAST24
Transmembranei380 – 401HelicalSequence analysisAdd BLAST22
Transmembranei421 – 440HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37

Expressioni

Gene expression databases

BgeeiENSG00000184160
ExpressionAtlasiQ4W594 baseline and differential

Interactioni

Chemistry databases

BindingDBiQ4W594

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 437G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST370

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOVERGENiHBG106962
KOiK04140
OMAiELMNYWY
OrthoDBiEOG091G06VI

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000735 ADRA2C_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF25 PTHR24248:SF25, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00560 ADRENRGCA2CR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4W594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPALAAAL AVAAAAGPNA SGAGERGSGG VANASGASWG PPRGQYSAGA
60 70 80 90 100
VAGLAAVVGF LIVFTVVGNV LVVIAVLTSR ALRAPQNLFL VSLASADILV
110 120 130 140 150
ATLVMPFSLA NELMAYWYFG QVWCGVYLAL DVLFCTSSIV HLCAISLDRY
160 170 180 190 200
WSVTQAVEYN LKRTPRRVKA TIVAVWLISA VISFPPLVSL YRQPDGAAYP
210 220 230 240 250
QCGLNDETWY ILSSCIGSFF APCLIMGLVY ARIYRVAKLR TRTLSEKRAP
260 270 280 290 300
VGPDGASPTT ENGLGAAAGA GENGHCAPPP ADVEPDESSA AAERRRRRGA
310 320 330 340 350
LRRGGRRRAG AEGGAGGADG QGAGPGAAES GALTASRSPG PGGRLSRASS
360 370 380 390 400
RSVEFFLSRR RRARSSVCRR KVAQAREKRF TFVLAVVMGV FVLCWFPFFF
410 420 430 440 450
SYSLYGICRE ACQVPGPLFK FFFWIGYCNS SLNPVIYTVF NQDFRRSFKH
460
ILFRRRRRGF RQ
Length:462
Mass (Da):49,522
Last modified:July 5, 2005 - v1
Checksum:iE1EF9CA21E7F6EDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142625 mRNA Translation: AAI42626.1
AC141928 Genomic DNA Translation: AAY41059.1
EU332833 Genomic DNA Translation: ABY87522.1
RefSeqiNP_000674.2, NM_000683.3
UniGeneiHs.123022

Genome annotation databases

GeneIDi152
KEGGihsa:152
UCSCiuc003ghm.4 human

Similar proteinsi

Entry informationi

Entry nameiQ4W594_HUMAN
AccessioniPrimary (citable) accession number: Q4W594
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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