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Protein

Polyadenylate-binding protein 1-like

Gene

PABPC1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 1-like
Gene namesi
Name:PABPC1L
Synonyms:C20orf119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101104.12.
HGNCiHGNC:15797. PABPC1L.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101104.
PharmGKBiPA162398552.

Polymorphism and mutation databases

BioMutaiPABPC1L.
DMDMi74754038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778791 – 614Polyadenylate-binding protein 1-likeAdd BLAST614

Proteomic databases

EPDiQ4VXU2.
MaxQBiQ4VXU2.
PaxDbiQ4VXU2.
PeptideAtlasiQ4VXU2.
PRIDEiQ4VXU2.

PTM databases

iPTMnetiQ4VXU2.
PhosphoSitePlusiQ4VXU2.
SwissPalmiQ4VXU2.

Expressioni

Gene expression databases

BgeeiENSG00000101104.
CleanExiHS_PABPC1L.
ExpressionAtlasiQ4VXU2. baseline and differential.
GenevisibleiQ4VXU2. HS.

Organism-specific databases

HPAiHPA066650.

Interactioni

Protein-protein interaction databases

BioGridi123246. 3 interactors.
IntActiQ4VXU2. 4 interactors.
STRINGi9606.ENSP00000217073.

Structurei

3D structure databases

ProteinModelPortaliQ4VXU2.
SMRiQ4VXU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini99 – 175RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 370RRM 4PROSITE-ProRule annotationAdd BLAST77
Domaini528 – 605PABCPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi409 – 458Pro-richAdd BLAST50

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123. Eukaryota.
ENOG410XR5X. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.
InParanoidiQ4VXU2.
KOiK13126.
OMAiPIMSIRV.
OrthoDBiEOG091G03ZE.
PhylomeDBiQ4VXU2.
TreeFamiTF300458.

Family and domain databases

InterProiView protein in InterPro
IPR036053. PABP-dom.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR035979. RBD_domain_sf.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
PfamiView protein in Pfam
PF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
SMARTiView protein in SMART
SM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
SM00361. RRM_1. 3 hits.
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF63570. SSF63570. 1 hit.
TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
PROSITEiView protein in PROSITE
PS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4VXU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNASGSGYPL ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDVATRR
60 70 80 90 100
SLGYAYINFQ QPADAERALD TMNFEMLKGQ PIRIMWSQRD PGLRKSGVGN
110 120 130 140 150
IFIKNLEDSI DNKALYDTFS TFGNILSCKV ACDEHGSRGF GFVHFETHEA
160 170 180 190 200
AQQAINTMNG MLLNDRKVFV GHFKSRRERE AELGARALEF TNIYVKNLPV
210 220 230 240 250
DVDEQGLQDL FSQFGKMLSV KVMRDNSGHS RCFGFVNFEK HEEAQKAVVH
260 270 280 290 300
MNGKEVSGRL LYAGRAQKRV ERQNELKRRF EQMKQDRLRR YQGVNLYVKN
310 320 330 340 350
LDDSIDDDKL RKEFSPYGVI TSAKVMTEGG HSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVGT KPLYVALAQR KEERKAILTN QYMQRLSTMR TLSNPLLGSF
410 420 430 440 450
QQPSSYFLPA MPQPPAQAAY YGCGPVTPTQ PAPRWTSQPP RPSCASMVRP
460 470 480 490 500
PVVPRRPPAH ISSVRQASTQ VPRTVPHTQR VANIGTQTTG PSGVGCCTPG
510 520 530 540 550
RPLLPCKCSS AAHSTYRVQE PAVHIPGQEP LTASMLAAAP LHEQKQMIGE
560 570 580 590 600
RLYPLIHDVH TQLAGKITGM LLEIDNSELL LMLESPESLH AKIDEAVAVL
610
QAHQAMEQPK AYMH
Length:614
Mass (Da):68,392
Last modified:July 5, 2005 - v1
Checksum:i3A809F527CE688FF
GO
Isoform 2 (identifier: Q4VXU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-330: VMTEGG → KRRQRP
     331-614: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):37,737
Checksum:iF32E4B65B9890FB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054047212S → A. Corresponds to variant dbSNP:rs2075960Ensembl.1
Natural variantiVAR_060184492S → G. Corresponds to variant dbSNP:rs6513956Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057071325 – 330VMTEGG → KRRQRP in isoform 2. 1 Publication6
Alternative sequenceiVSP_057072331 – 614Missing in isoform 2. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU190483 mRNA. Translation: ABY64766.1.
AL109839 Genomic DNA. No translation available.
AL008725 Genomic DNA. No translation available.
CCDSiCCDS42878.1. [Q4VXU2-1]
RefSeqiNP_001118228.1. NM_001124756.2. [Q4VXU2-1]
UniGeneiHs.641481.

Genome annotation databases

EnsembliENST00000217073; ENSP00000217073; ENSG00000101104. [Q4VXU2-1]
ENST00000217074; ENSP00000217074; ENSG00000101104. [Q4VXU2-2]
ENST00000255136; ENSP00000255136; ENSG00000101104. [Q4VXU2-1]
ENST00000537323; ENSP00000445661; ENSG00000101104. [Q4VXU2-2]
GeneIDi80336.
KEGGihsa:80336.
UCSCiuc010ggv.1. human. [Q4VXU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPAP1L_HUMAN
AccessioniPrimary (citable) accession number: Q4VXU2
Secondary accession number(s): Q4VY17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: November 22, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families