Q4VXU2 (PAP1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polyadenylate-binding protein 1-like

Gene names

Name:	PABPC1L
Synonyms:	C20orf119

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	614 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the polyadenylate-binding protein type-1 family. Contains 1 PABC domain. Contains 4 RRM (RNA recognition motif) domains.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	RNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 614	614	Polyadenylate-binding protein 1-like		PRO_0000277879
Regions
	Domain	11 – 89	79	RRM 1
	Domain	99 – 175	77	RRM 2
	Domain	191 – 268	78	RRM 3
	Domain	294 – 370	77	RRM 4
	Domain	528 – 605	78	PABC
	Compositional bias	409 – 458	50	Pro-rich
Natural variations
	Natural variant	212	1	S → A. Corresponds to variant rs2075960 [ dbSNP | Ensembl ].		VAR_054047
	Natural variant	492	1	S → G. Corresponds to variant rs6513956 [ dbSNP | Ensembl ].		VAR_060184

Sequences

	Sequence		Length	Mass (Da)
	Q4VXU2 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 3A809F527CE688FF	FASTA	614	68,392
	10 20 30 40 50 60 MNASGSGYPL ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDVATRR SLGYAYINFQ 70 80 90 100 110 120 QPADAERALD TMNFEMLKGQ PIRIMWSQRD PGLRKSGVGN IFIKNLEDSI DNKALYDTFS 130 140 150 160 170 180 TFGNILSCKV ACDEHGSRGF GFVHFETHEA AQQAINTMNG MLLNDRKVFV GHFKSRRERE 190 200 210 220 230 240 AELGARALEF TNIYVKNLPV DVDEQGLQDL FSQFGKMLSV KVMRDNSGHS RCFGFVNFEK 250 260 270 280 290 300 HEEAQKAVVH MNGKEVSGRL LYAGRAQKRV ERQNELKRRF EQMKQDRLRR YQGVNLYVKN 310 320 330 340 350 360 LDDSIDDDKL RKEFSPYGVI TSAKVMTEGG HSKGFGFVCF SSPEEATKAV TEMNGRIVGT 370 380 390 400 410 420 KPLYVALAQR KEERKAILTN QYMQRLSTMR TLSNPLLGSF QQPSSYFLPA MPQPPAQAAY 430 440 450 460 470 480 YGCGPVTPTQ PAPRWTSQPP RPSCASMVRP PVVPRRPPAH ISSVRQASTQ VPRTVPHTQR 490 500 510 520 530 540 VANIGTQTTG PSGVGCCTPG RPLLPCKCSS AAHSTYRVQE PAVHIPGQEP LTASMLAAAP 550 560 570 580 590 600 LHEQKQMIGE RLYPLIHDVH TQLAGKITGM LLEIDNSELL LMLESPESLH AKIDEAVAVL 610 QAHQAMEQPK AYMH

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL109839, AL008725 Genomic DNA. Translation: CAI95631.1. AL008725, AL109839 Genomic DNA. Translation: CAI95662.1.
IPI	IPI00556259.
RefSeq	NP_001118228.1. NM_001124756.1.
UniGene	Hs.641481.
3D structure databases
HSSP	HSSP built from PDB template 1CVJ based on UniProtKB P11940.
ProteinModelPortal	Q4VXU2.
SMR	Q4VXU2. Positions 9-385, 530-605.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q4VXU2. 1 interaction.
STRING	Q4VXU2.
PTM databases
PhosphoSite	Q4VXU2.
Polymorphism databases
DMDM	74754038.
Proteomic databases
PRIDE	Q4VXU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000217073; ENSP00000217073; ENSG00000101104. ENST00000255136; ENSP00000255136; ENSG00000101104.
GeneID	80336.
KEGG	hsa:80336.
UCSC	uc010ggv.1. human.
Organism-specific databases
CTD	80336.
GeneCards	GC20P043538.
HGNC	HGNC:15797. PABPC1L.
neXtProt	NX_Q4VXU2.
PharmGKB	PA162398552.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00590000082738.
HOGENOM	HBG756718.
HOVERGEN	HBG002295.
InParanoid	Q4VXU2.
OMA	DTMNFEM.
OrthoDB	EOG4K6G3V.
PhylomeDB	Q4VXU2.
Gene expression databases
ArrayExpress	Q4VXU2.
Bgee	Q4VXU2.
CleanEx	HS_PABPC1L.
Genevestigator	Q4VXU2.
Family and domain databases
InterPro	IPR012677. Nucleotide-bd_a/b_plait. IPR006515. PABP_1234. IPR002004. PABP_HYD. IPR000504. RRM_dom. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 4 hits. G3DSA:1.10.1900.10. PABP_HYD. 1 hit.
KO	K13126.
Pfam	PF00658. PABP. 1 hit. PF00076. RRM_1. 4 hits. [Graphical view]
SMART	SM00517. PolyA. 1 hit. SM00360. RRM. 4 hits. [Graphical view]
SUPFAM	SSF63570. PABP_HYD. 1 hit.
TIGRFAMs	TIGR01628. PABP-1234. 1 hit.
PROSITE	PS51309. PABC. 1 hit. PS50102. RRM. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	70904.

Entry information

Entry name

PAP1L_HUMAN

Accession

Primary (citable) accession number: Q4VXU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.