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Protein

Polyadenylate-binding protein 1-like

Gene

PABPC1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 1-like
Gene namesi
Name:PABPC1L
Synonyms:C20orf119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15797. PABPC1L.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398552.

Polymorphism and mutation databases

BioMutaiPABPC1L.
DMDMi74754038.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Polyadenylate-binding protein 1-likePRO_0000277879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei299 – 2991N6-methyllysineBy similarity
Modified residuei315 – 3151PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ4VXU2.
MaxQBiQ4VXU2.
PaxDbiQ4VXU2.
PeptideAtlasiQ4VXU2.
PRIDEiQ4VXU2.

PTM databases

iPTMnetiQ4VXU2.
PhosphoSiteiQ4VXU2.
SwissPalmiQ4VXU2.

Expressioni

Gene expression databases

BgeeiQ4VXU2.
CleanExiHS_PABPC1L.
ExpressionAtlasiQ4VXU2. baseline and differential.
GenevisibleiQ4VXU2. HS.

Interactioni

Protein-protein interaction databases

BioGridi123246. 3 interactions.
IntActiQ4VXU2. 3 interactions.
STRINGi9606.ENSP00000217073.

Structurei

3D structure databases

ProteinModelPortaliQ4VXU2.
SMRiQ4VXU2. Positions 11-376, 530-605.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8979RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini99 – 17577RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini191 – 26878RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 37077RRM 4PROSITE-ProRule annotationAdd
BLAST
Domaini528 – 60578PABCPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi409 – 45850Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 PABC domain.PROSITE-ProRule annotation
Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123. Eukaryota.
ENOG410XR5X. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.
InParanoidiQ4VXU2.
KOiK13126.
OMAiIRAPPHE.
OrthoDBiEOG7RV9FP.
PhylomeDBiQ4VXU2.
TreeFamiTF300458.

Family and domain databases

Gene3Di1.10.1900.10. 1 hit.
3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
SM00361. RRM_1. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF63570. SSF63570. 1 hit.
TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
PROSITEiPS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4VXU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNASGSGYPL ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDVATRR
60 70 80 90 100
SLGYAYINFQ QPADAERALD TMNFEMLKGQ PIRIMWSQRD PGLRKSGVGN
110 120 130 140 150
IFIKNLEDSI DNKALYDTFS TFGNILSCKV ACDEHGSRGF GFVHFETHEA
160 170 180 190 200
AQQAINTMNG MLLNDRKVFV GHFKSRRERE AELGARALEF TNIYVKNLPV
210 220 230 240 250
DVDEQGLQDL FSQFGKMLSV KVMRDNSGHS RCFGFVNFEK HEEAQKAVVH
260 270 280 290 300
MNGKEVSGRL LYAGRAQKRV ERQNELKRRF EQMKQDRLRR YQGVNLYVKN
310 320 330 340 350
LDDSIDDDKL RKEFSPYGVI TSAKVMTEGG HSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVGT KPLYVALAQR KEERKAILTN QYMQRLSTMR TLSNPLLGSF
410 420 430 440 450
QQPSSYFLPA MPQPPAQAAY YGCGPVTPTQ PAPRWTSQPP RPSCASMVRP
460 470 480 490 500
PVVPRRPPAH ISSVRQASTQ VPRTVPHTQR VANIGTQTTG PSGVGCCTPG
510 520 530 540 550
RPLLPCKCSS AAHSTYRVQE PAVHIPGQEP LTASMLAAAP LHEQKQMIGE
560 570 580 590 600
RLYPLIHDVH TQLAGKITGM LLEIDNSELL LMLESPESLH AKIDEAVAVL
610
QAHQAMEQPK AYMH
Length:614
Mass (Da):68,392
Last modified:July 5, 2005 - v1
Checksum:i3A809F527CE688FF
GO
Isoform 2 (identifier: Q4VXU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-330: VMTEGG → KRRQRP
     331-614: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):37,737
Checksum:iF32E4B65B9890FB5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti212 – 2121S → A.
Corresponds to variant rs2075960 [ dbSNP | Ensembl ].
VAR_054047
Natural varianti492 – 4921S → G.
Corresponds to variant rs6513956 [ dbSNP | Ensembl ].
VAR_060184

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 3306VMTEGG → KRRQRP in isoform 2. 1 PublicationVSP_057071
Alternative sequencei331 – 614284Missing in isoform 2. 1 PublicationVSP_057072Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU190483 mRNA. Translation: ABY64766.1.
AL109839, AL008725 Genomic DNA. Translation: CAI95631.1.
AL008725, AL109839 Genomic DNA. Translation: CAI95662.1.
CCDSiCCDS42878.1. [Q4VXU2-1]
RefSeqiNP_001118228.1. NM_001124756.2. [Q4VXU2-1]
XP_011527358.1. XM_011529056.1. [Q4VXU2-1]
UniGeneiHs.641481.

Genome annotation databases

EnsembliENST00000217073; ENSP00000217073; ENSG00000101104. [Q4VXU2-1]
ENST00000217074; ENSP00000217074; ENSG00000101104. [Q4VXU2-2]
ENST00000255136; ENSP00000255136; ENSG00000101104. [Q4VXU2-1]
ENST00000537323; ENSP00000445661; ENSG00000101104. [Q4VXU2-2]
GeneIDi80336.
KEGGihsa:80336.
UCSCiuc010ggv.1. human. [Q4VXU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU190483 mRNA. Translation: ABY64766.1.
AL109839, AL008725 Genomic DNA. Translation: CAI95631.1.
AL008725, AL109839 Genomic DNA. Translation: CAI95662.1.
CCDSiCCDS42878.1. [Q4VXU2-1]
RefSeqiNP_001118228.1. NM_001124756.2. [Q4VXU2-1]
XP_011527358.1. XM_011529056.1. [Q4VXU2-1]
UniGeneiHs.641481.

3D structure databases

ProteinModelPortaliQ4VXU2.
SMRiQ4VXU2. Positions 11-376, 530-605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123246. 3 interactions.
IntActiQ4VXU2. 3 interactions.
STRINGi9606.ENSP00000217073.

PTM databases

iPTMnetiQ4VXU2.
PhosphoSiteiQ4VXU2.
SwissPalmiQ4VXU2.

Polymorphism and mutation databases

BioMutaiPABPC1L.
DMDMi74754038.

Proteomic databases

EPDiQ4VXU2.
MaxQBiQ4VXU2.
PaxDbiQ4VXU2.
PeptideAtlasiQ4VXU2.
PRIDEiQ4VXU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217073; ENSP00000217073; ENSG00000101104. [Q4VXU2-1]
ENST00000217074; ENSP00000217074; ENSG00000101104. [Q4VXU2-2]
ENST00000255136; ENSP00000255136; ENSG00000101104. [Q4VXU2-1]
ENST00000537323; ENSP00000445661; ENSG00000101104. [Q4VXU2-2]
GeneIDi80336.
KEGGihsa:80336.
UCSCiuc010ggv.1. human. [Q4VXU2-1]

Organism-specific databases

CTDi80336.
GeneCardsiPABPC1L.
HGNCiHGNC:15797. PABPC1L.
neXtProtiNX_Q4VXU2.
PharmGKBiPA162398552.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0123. Eukaryota.
ENOG410XR5X. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000217922.
HOVERGENiHBG002295.
InParanoidiQ4VXU2.
KOiK13126.
OMAiIRAPPHE.
OrthoDBiEOG7RV9FP.
PhylomeDBiQ4VXU2.
TreeFamiTF300458.

Miscellaneous databases

ChiTaRSiPABPC1L. human.
GenomeRNAii80336.
PROiQ4VXU2.

Gene expression databases

BgeeiQ4VXU2.
CleanExiHS_PABPC1L.
ExpressionAtlasiQ4VXU2. baseline and differential.
GenevisibleiQ4VXU2. HS.

Family and domain databases

Gene3Di1.10.1900.10. 1 hit.
3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR000504. RRM_dom.
IPR003954. RRM_dom_euk.
[Graphical view]
PfamiPF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
[Graphical view]
SMARTiSM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
SM00361. RRM_1. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF63570. SSF63570. 1 hit.
TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
PROSITEiPS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Sakugawa N.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPAP1L_HUMAN
AccessioniPrimary (citable) accession number: Q4VXU2
Secondary accession number(s): Q4VY17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.