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Protein

Synaptotagmin-like protein 3

Gene

SYTL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 3
Alternative name(s):
Exophilin-6
Gene namesi
Name:SYTL3
Synonyms:SLP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:15587. SYTL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37986.

Polymorphism and mutation databases

BioMutaiSYTL3.
DMDMi259016380.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Synaptotagmin-like protein 3PRO_0000311116Add
BLAST

Proteomic databases

EPDiQ4VX76.
PaxDbiQ4VX76.
PeptideAtlasiQ4VX76.
PRIDEiQ4VX76.

PTM databases

iPTMnetiQ4VX76.
PhosphoSiteiQ4VX76.

Expressioni

Gene expression databases

BgeeiQ4VX76.
CleanExiHS_SYTL3.
GenevisibleiQ4VX76. HS.

Organism-specific databases

HPAiHPA030584.
HPA030585.
HPA030586.

Interactioni

Subunit structurei

Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125119. 4 interactions.
IntActiQ4VX76. 2 interactions.
MINTiMINT-7969198.
STRINGi9606.ENSP00000297239.

Structurei

3D structure databases

ProteinModelPortaliQ4VX76.
SMRiQ4VX76. Positions 5-137, 306-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 123120RabBDPROSITE-ProRule annotationAdd
BLAST
Domaini308 – 412105C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini467 – 571105C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00810000125376.
HOGENOMiHOG000231332.
HOVERGENiHBG103087.
InParanoidiQ4VX76.
KOiK17598.
OMAiFVKGCLT.
OrthoDBiEOG7P02HG.
PhylomeDBiQ4VX76.
TreeFamiTF341184.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR010911. Rab_BD.
IPR028704. SYTL3.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF222. PTHR10024:SF222. 1 hit.
PfamiPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4VX76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQEIDLSAL KELEREAILQ VLYRDQAVQN TEEERTRKLK THLQHLRWKG
60 70 80 90 100
AKNTDWEHKE KCCARCQQVL GFLLHRGAVC RGCSHRVCAQ CRVFLRGTHA
110 120 130 140 150
WKCTVCFEDR NVKIKTGEWF YEERAKKFPT GGKHETVGGQ LLQSYQKLSK
160 170 180 190 200
ISVVPPTPPP VSESQCSRSP GRLQEFGQFR GFNKSVENLF LSLATHVKKL
210 220 230 240 250
SKSQNDMTSE KHLLATGPRQ CVGQTERRSQ SDTAVNVTTR KVSAPDILKP
260 270 280 290 300
LNQEDPKCST NPILKQQNLP SSPAPSTIFS GGFRHGSLIS IDSTCTEMGN
310 320 330 340 350
FDNANVTGEI EFAIHYCFKT HSLEICIKAC KNLAYGEEKK KKCNPYVKTY
360 370 380 390 400
LLPDRSSQGK RKTGVQRNTV DPTFQETLKY QVAPAQLVTR QLQVSVWHLG
410 420 430 440 450
TLARRVFLGE VIIPLATWDF EDSTTQSFRW HPLRAKAEKY EDSVPQSNGE
460 470 480 490 500
LTVRAKLVLP SRPRKLQEAQ EGTDQPSLHG QLCLVVLGAK NLPVRPDGTL
510 520 530 540 550
NSFVKGCLTL PDQQKLRLKS PVLRKQACPQ WKHSFVFSGV TPAQLRQSSL
560 570 580 590 600
ELTVWDQALF GMNDRLLGGT RLGSKGDTAV GGDACSLSKL QWQKVLSSPN
610
LWTDMTLVLH
Length:610
Mass (Da):68,560
Last modified:September 22, 2009 - v3
Checksum:iAFD69AFE759AC3C2
GO
Isoform 2 (identifier: Q4VX76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-239: Missing.

Show »
Length:542
Mass (Da):60,925
Checksum:i3163454EAC6E4C58
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti414 – 4141P → S.
Corresponds to variant rs901363 [ dbSNP | Ensembl ].
VAR_037137
Natural varianti540 – 5401V → I.
Corresponds to variant rs2291388 [ dbSNP | Ensembl ].
VAR_037138
Natural varianti587 – 5871L → Q.2 Publications
Corresponds to variant rs3123101 [ dbSNP | Ensembl ].
VAR_037139

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei172 – 23968Missing in isoform 2. 1 PublicationVSP_029403Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589931 Genomic DNA. Translation: CAI95305.1.
CH471051 Genomic DNA. Translation: EAW47653.1.
BC085612 mRNA. Translation: AAH85612.1.
BC100830 mRNA. Translation: AAI00831.1.
BC100831 mRNA. Translation: AAI00832.1.
CCDSiCCDS34563.1. [Q4VX76-2]
CCDS56458.1. [Q4VX76-1]
RefSeqiNP_001009991.2. NM_001009991.3. [Q4VX76-2]
NP_001229313.1. NM_001242384.1. [Q4VX76-1]
NP_001229323.1. NM_001242394.1. [Q4VX76-1]
NP_001305674.1. NM_001318745.1.
XP_005267271.1. XM_005267214.3. [Q4VX76-1]
XP_005267272.1. XM_005267215.3. [Q4VX76-1]
XP_006715668.1. XM_006715605.2. [Q4VX76-1]
XP_006715669.1. XM_006715606.2. [Q4VX76-1]
XP_006715671.1. XM_006715608.2. [Q4VX76-2]
XP_011534556.1. XM_011536254.1. [Q4VX76-1]
UniGeneiHs.436977.
Hs.733155.

Genome annotation databases

EnsembliENST00000297239; ENSP00000297239; ENSG00000164674. [Q4VX76-1]
ENST00000360448; ENSP00000353631; ENSG00000164674. [Q4VX76-1]
ENST00000367081; ENSP00000356048; ENSG00000164674. [Q4VX76-2]
ENST00000611299; ENSP00000483936; ENSG00000164674. [Q4VX76-1]
GeneIDi94120.
KEGGihsa:94120.
UCSCiuc003qrp.3. human. [Q4VX76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589931 Genomic DNA. Translation: CAI95305.1.
CH471051 Genomic DNA. Translation: EAW47653.1.
BC085612 mRNA. Translation: AAH85612.1.
BC100830 mRNA. Translation: AAI00831.1.
BC100831 mRNA. Translation: AAI00832.1.
CCDSiCCDS34563.1. [Q4VX76-2]
CCDS56458.1. [Q4VX76-1]
RefSeqiNP_001009991.2. NM_001009991.3. [Q4VX76-2]
NP_001229313.1. NM_001242384.1. [Q4VX76-1]
NP_001229323.1. NM_001242394.1. [Q4VX76-1]
NP_001305674.1. NM_001318745.1.
XP_005267271.1. XM_005267214.3. [Q4VX76-1]
XP_005267272.1. XM_005267215.3. [Q4VX76-1]
XP_006715668.1. XM_006715605.2. [Q4VX76-1]
XP_006715669.1. XM_006715606.2. [Q4VX76-1]
XP_006715671.1. XM_006715608.2. [Q4VX76-2]
XP_011534556.1. XM_011536254.1. [Q4VX76-1]
UniGeneiHs.436977.
Hs.733155.

3D structure databases

ProteinModelPortaliQ4VX76.
SMRiQ4VX76. Positions 5-137, 306-599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125119. 4 interactions.
IntActiQ4VX76. 2 interactions.
MINTiMINT-7969198.
STRINGi9606.ENSP00000297239.

PTM databases

iPTMnetiQ4VX76.
PhosphoSiteiQ4VX76.

Polymorphism and mutation databases

BioMutaiSYTL3.
DMDMi259016380.

Proteomic databases

EPDiQ4VX76.
PaxDbiQ4VX76.
PeptideAtlasiQ4VX76.
PRIDEiQ4VX76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297239; ENSP00000297239; ENSG00000164674. [Q4VX76-1]
ENST00000360448; ENSP00000353631; ENSG00000164674. [Q4VX76-1]
ENST00000367081; ENSP00000356048; ENSG00000164674. [Q4VX76-2]
ENST00000611299; ENSP00000483936; ENSG00000164674. [Q4VX76-1]
GeneIDi94120.
KEGGihsa:94120.
UCSCiuc003qrp.3. human. [Q4VX76-1]

Organism-specific databases

CTDi94120.
GeneCardsiSYTL3.
HGNCiHGNC:15587. SYTL3.
HPAiHPA030584.
HPA030585.
HPA030586.
neXtProtiNX_Q4VX76.
PharmGKBiPA37986.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00810000125376.
HOGENOMiHOG000231332.
HOVERGENiHBG103087.
InParanoidiQ4VX76.
KOiK17598.
OMAiFVKGCLT.
OrthoDBiEOG7P02HG.
PhylomeDBiQ4VX76.
TreeFamiTF341184.

Miscellaneous databases

ChiTaRSiSYTL3. human.
GenomeRNAii94120.
PROiQ4VX76.

Gene expression databases

BgeeiQ4VX76.
CleanExiHS_SYTL3.
GenevisibleiQ4VX76. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR010911. Rab_BD.
IPR028704. SYTL3.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF222. PTHR10024:SF222. 1 hit.
PfamiPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLN-587.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-587.
    Tissue: Chondrosarcoma.

Entry informationi

Entry nameiSYTL3_HUMAN
AccessioniPrimary (citable) accession number: Q4VX76
Secondary accession number(s): Q496J4, Q496J6, Q5U3B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 22, 2009
Last modified: July 6, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.