ID   S31A7_HUMAN             Reviewed;        1347 AA.
AC   Q8IWB4; Q4VX67; Q5TZK4; Q9Y4Q5;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 4.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Spermatogenesis-associated protein 31A7 {ECO:0000305};
DE   AltName: Full=Protein FAM75A7 {ECO:0000305};
GN   Name=SPATA31A7 {ECO:0000312|HGNC:HGNC:32007};
GN   Synonyms=FAM75A4 {ECO:0000312|HGNC:HGNC:32007}, FAM75A7
GN   {ECO:0000312|HGNC:HGNC:32007}, SPATA31A4
GN   {ECO:0000312|HGNC:HGNC:32007};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in spermatogenesis. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8IWB4; P81534: DEFB103B; NbExp=3; IntAct=EBI-1222614, EBI-12074168;
CC       Q8IWB4; A1E959: ODAM; NbExp=3; IntAct=EBI-1222614, EBI-5774125;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SPATA31 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH40528.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL596385; CAI95396.1; -; Genomic_DNA.
DR   EMBL; BX005040; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC040528; AAH40528.1; ALT_INIT; mRNA.
DR   CCDS; CCDS75838.1; -.
DR   PIR; T12532; T12532.
DR   RefSeq; NP_056482.2; NM_015667.2.
DR   AlphaFoldDB; Q8IWB4; -.
DR   BioGRID; 117591; 5.
DR   IntAct; Q8IWB4; 3.
DR   STRING; 9606.ENSP00000484807; -.
DR   iPTMnet; Q8IWB4; -.
DR   PhosphoSitePlus; Q8IWB4; -.
DR   BioMuta; SPATA31A7; -.
DR   DMDM; 166215080; -.
DR   jPOST; Q8IWB4; -.
DR   MassIVE; Q8IWB4; -.
DR   PaxDb; 9606-ENSP00000484807; -.
DR   PeptideAtlas; Q8IWB4; -.
DR   ProteomicsDB; 70834; -.
DR   DNASU; 26165; -.
DR   Ensembl; ENST00000619167.2; ENSP00000484807.1; ENSG00000276040.5.
DR   GeneID; 26165; -.
DR   KEGG; hsa:26165; -.
DR   MANE-Select; ENST00000619167.2; ENSP00000484807.1; NM_015667.2; NP_056482.2.
DR   UCSC; uc033ctg.2; human.
DR   AGR; HGNC:32007; -.
DR   DisGeNET; 26165; -.
DR   GeneCards; SPATA31A7; -.
DR   HGNC; HGNC:32007; SPATA31A7.
DR   HPA; ENSG00000276040; Tissue enriched (testis).
DR   MIM; 616584; gene.
DR   neXtProt; NX_Q8IWB4; -.
DR   PharmGKB; PA162387900; -.
DR   VEuPathDB; HostDB:ENSG00000276040; -.
DR   eggNOG; ENOG502RU0E; Eukaryota.
DR   GeneTree; ENSGT00950000183043; -.
DR   HOGENOM; CLU_005668_2_0_1; -.
DR   InParanoid; Q8IWB4; -.
DR   OMA; MACSHET; -.
DR   OrthoDB; 4838108at2759; -.
DR   PhylomeDB; Q8IWB4; -.
DR   TreeFam; TF338531; -.
DR   PathwayCommons; Q8IWB4; -.
DR   SignaLink; Q8IWB4; -.
DR   BioGRID-ORCS; 26165; 66 hits in 651 CRISPR screens.
DR   GenomeRNAi; 26165; -.
DR   Pharos; Q8IWB4; Tdark.
DR   PRO; PR:Q8IWB4; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q8IWB4; Protein.
DR   Bgee; ENSG00000276040; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 62 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR039509; SPATA31.
DR   InterPro; IPR027970; SPATA31F3-like.
DR   PANTHER; PTHR21859; ACROSOME-SPECIFIC PROTEIN; 1.
DR   PANTHER; PTHR21859:SF55; SPERMATOGENESIS-ASSOCIATED PROTEIN 31A1-RELATED; 1.
DR   Pfam; PF15371; DUF4599; 1.
DR   Pfam; PF14650; FAM75; 1.
DR   Genevisible; Q8IWB4; HS.
PE   1: Evidence at protein level;
KW   Differentiation; Membrane; Reference proteome; Spermatogenesis;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..1347
FT                   /note="Spermatogenesis-associated protein 31A7"
FT                   /id="PRO_0000280245"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          55..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          628..658
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          900..955
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1084..1161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1313..1335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..78
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..226
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..656
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        925..951
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1105..1128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        41
FT                   /note="L -> V (in Ref. 1; CAI95396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        64
FT                   /note="C -> S (in Ref. 2; AAH40528)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88
FT                   /note="P -> R (in Ref. 1; CAI95396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        297
FT                   /note="V -> A (in Ref. 2; AAH40528)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        362
FT                   /note="Y -> S (in Ref. 1; CAI95396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        472
FT                   /note="L -> P (in Ref. 2; AAH40528)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        625
FT                   /note="Q -> R (in Ref. 2; AAH40528)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        749
FT                   /note="C -> R (in Ref. 1; CAI95396)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1199
FT                   /note="V -> A (in Ref. 2; AAH40528)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1219
FT                   /note="E -> K (in Ref. 1; CAI95396)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1347 AA;  148734 MW;  BE571EC6050FF9A9 CRC64;
     MENLPFPLKL LSASSLNAPS STPWVLDIFL TLVFALGFFF LLLPYLSYFR CDDPPSPSPG
     KRKCPVGRRR RPRGRMKNHS LRAGRECPRG LEETSDLLSQ LQSLLGPHLD KGDFGQLSGP
     DPPGEVGERA PDGASQSSHE PMEDAAPILS PLASPDPQAK HPQDLASTPS PGPMTTSVSS
     LSASQPPEPS LPLEHPSPEP PALFPHPPHT PDPLACSLPP PKGFTAPPLR DSTLITPSHC
     DSVAFPLGTV PQSLSPHEDL VASVPAISGL GGSNSHVSAS SRWQETARTS CAFNSSVQQD
     HLSRHPPETC QMEAGSLFLL SSDGQNVVGI QVTETAKVNI WEEKENVGSF TNRMTPEKHL
     NYLRNLAKSL DAEQDTTNPK PFWNMGENSK QLPGPQKLSD PRLWQESFWK NYSQLFWGLP
     SLHSESLVAN AWVTDRSYTL QSPPFLFNEM SNVCPIQRET TMSPLLFQAQ PLSHLGPECQ
     PFISSTPQFR PTPMAQAEAQ AHLQSSFPVL SPAFPSLIQN TGVACPASQN KVQALSLPET
     QHPEWPLLRR QLEGRLALPS RVQKSQDVFS VSTPNLPQES LTSILPENFP VSPELRRQLE
     QHIKKWIIQH WGNLGRIQES LDLMQLRDES PGTSQAKGKP SPWQSSMSTG ESSKEAQKVK
     FQLERDPCPH LGQILGETPQ NLSRDMKSFP RKVLGVTSEE LERNLRKPLR SDSGSDLLRC
     TERTHIENIL KAHMGRNLGQ TNEGLIPVCV RRSWLAVNQA LPVSNTHVKT SNLAAPKSGK
     ACVNTAQVLS FLEPCTQQGL GAHIVRFWAK HRWGLPLRVL KPIQCFKLEK VSSLSLTQLA
     GPSSATCESG AGSEVEVDMF LRKPPMASLR KQVLTKASDH MPESLLASSP AWKQFQRAPR
     GIPSWNDHEP LKPPPAGQEG RWPSKPLTYS LTGSIQQSRS LGAQSSKAGE TREAVPQCRV
     PLETCMLANL QATSEDVHGF EAPGTSKSSL HPRVSVSQDP RKLCLMEEVV NEFEPGMATK
     SETQPQVCAA VVLLPDGQAS VVPHASENLV SQVPQGHLQS MPTGNMRASQ ELHDLMAARR
     SKLVHEEPRN PNCQGSCKSQ RPMFPPIHKS EKSRKPNLEK HEERLEGLRT PQLTPVRKTE
     DTHQDEGVQL LPSKKQPPSV SPFGENIKQI FQWIFSKKKS KPAPVTAESQ KTVKNRSRVY
     SSSAEAQGLM TAVGQMLDEK MSLCHARHAS KVNQHKQKFQ APVCGFPCNH RHLFYSEHGR
     ILSYAASSQQ ATLKSQGCPN RDRQIRNQQP LKSVRCNNEQ WGLRHPQILH PKKAVSPVSP
     PQHWPKTSGA SSHHHHCPRH CLLWEGI
//