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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Active sitei95 – 951Proton donorPROSITE-ProRule annotation
Binding sitei227 – 2271SubstrateBy similarity
Binding sitei245 – 2451SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
ORF Names:CPSG_08082
OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Taxonomic identifieri443226 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000002497: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_0000134657Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ4VWW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 643Substrate bindingBy similarity
Regioni93 – 10210Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

OrthoDBiEOG7CVQ76.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4VWW3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKSQFPYE DRARDHPNPL ARRLFQIATE KQSNVVVSAD VTTTKELLDL
60 70 80 90 100
ADRLGPYMVV LKTHIDILAD FSAETITGLQ SLSQKHNFLI FEDRKFVDIG
110 120 130 140 150
NTVQKQYHGG ALHISEWAHI VNATVLPGPG IIDALAQVAS APDFPHASDR
160 170 180 190 200
GLLILATMTS KGSLATGQYT ELSVELARKY KGFVLGFVAS RSLEGVETAG
210 220 230 240 250
KADDEDFVLF TTGVNLASKG DALGQQYQTP ESAIGGGADF IISGRGIYAA
260 270
PDPVDAARRY QKAGWDAYLK RVGR
Length:274
Mass (Da):29,683
Last modified:July 5, 2005 - v1
Checksum:i642F23A5FAC8CC20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY282521 Genomic DNA. Translation: AAQ16206.1.
GL636500 Genomic DNA. Translation: EFW15645.1.
AJ292100 Genomic DNA. Translation: CAC35044.1.
AJ292101 Genomic DNA. Translation: CAC35045.1.
AJ292102 Genomic DNA. Translation: CAC35046.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY282521 Genomic DNA. Translation: AAQ16206.1.
GL636500 Genomic DNA. Translation: EFW15645.1.
AJ292100 Genomic DNA. Translation: CAC35044.1.
AJ292101 Genomic DNA. Translation: CAC35045.1.
AJ292102 Genomic DNA. Translation: CAC35046.1.

3D structure databases

ProteinModelPortaliQ4VWW3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiEOG7CVQ76.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and confirmation of function of the Coccidioides posadasii URA3 (orotidine-5'-monophosphate decarboxylase) gene."
    Chen X., Hung C.-Y., Cole G.T.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RMSCC 757 / Silveira.
  3. "Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis."
    Koufopanou V., Burt A., Taylor J.W.
    Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-201.
    Strain: RMSCC 2233 / TX2, RMSCC 2343 / MX1 and RMSCC 757 / Silveira.
  4. Erratum
    Koufopanou V., Burt A., Taylor J.W.
    Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)

Entry informationi

Entry nameiPYRF_COCPS
AccessioniPrimary (citable) accession number: Q4VWW3
Secondary accession number(s): E9DDC0, Q9C0T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: January 7, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.