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Q4VWW3

- PYRF_COCPS

UniProt

Q4VWW3 - PYRF_COCPS

Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA3

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401SubstrateBy similarity
    Active sitei95 – 951Proton donorPROSITE-ProRule annotation
    Binding sitei227 – 2271SubstrateBy similarity
    Binding sitei245 – 2451SubstrateBy similarity

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
    Alternative name(s):
    OMP decarboxylase
    Short name:
    OMPDCase
    Short name:
    OMPdecase
    Uridine 5'-monophosphate synthase
    Short name:
    UMP synthase
    Gene namesi
    Name:URA3
    ORF Names:CPSG_08082
    OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
    Taxonomic identifieri443226 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000002497: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 274274Orotidine 5'-phosphate decarboxylasePRO_0000134657Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ4VWW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 643Substrate bindingBy similarity
    Regioni93 – 10210Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family.Curated

    Phylogenomic databases

    OrthoDBiEOG7CVQ76.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4VWW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKSQFPYE DRARDHPNPL ARRLFQIATE KQSNVVVSAD VTTTKELLDL    50
    ADRLGPYMVV LKTHIDILAD FSAETITGLQ SLSQKHNFLI FEDRKFVDIG 100
    NTVQKQYHGG ALHISEWAHI VNATVLPGPG IIDALAQVAS APDFPHASDR 150
    GLLILATMTS KGSLATGQYT ELSVELARKY KGFVLGFVAS RSLEGVETAG 200
    KADDEDFVLF TTGVNLASKG DALGQQYQTP ESAIGGGADF IISGRGIYAA 250
    PDPVDAARRY QKAGWDAYLK RVGR 274
    Length:274
    Mass (Da):29,683
    Last modified:July 5, 2005 - v1
    Checksum:i642F23A5FAC8CC20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY282521 Genomic DNA. Translation: AAQ16206.1.
    GL636500 Genomic DNA. Translation: EFW15645.1.
    AJ292100 Genomic DNA. Translation: CAC35044.1.
    AJ292101 Genomic DNA. Translation: CAC35045.1.
    AJ292102 Genomic DNA. Translation: CAC35046.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY282521 Genomic DNA. Translation: AAQ16206.1 .
    GL636500 Genomic DNA. Translation: EFW15645.1 .
    AJ292100 Genomic DNA. Translation: CAC35044.1 .
    AJ292101 Genomic DNA. Translation: CAC35045.1 .
    AJ292102 Genomic DNA. Translation: CAC35046.1 .

    3D structure databases

    ProteinModelPortali Q4VWW3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7CVQ76.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and confirmation of function of the Coccidioides posadasii URA3 (orotidine-5'-monophosphate decarboxylase) gene."
      Chen X., Hung C.-Y., Cole G.T.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RMSCC 757 / Silveira.
    3. "Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis."
      Koufopanou V., Burt A., Taylor J.W.
      Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-201.
      Strain: RMSCC 2233 / TX2, RMSCC 2343 / MX1 and RMSCC 757 / Silveira.
    4. Erratum
      Koufopanou V., Burt A., Taylor J.W.
      Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)

    Entry informationi

    Entry nameiPYRF_COCPS
    AccessioniPrimary (citable) accession number: Q4VWW3
    Secondary accession number(s): E9DDC0, Q9C0T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3