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Q4VWW3 (PYRF_COCPS) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
ORF Names:CPSG_08082
OrganismCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus) [Complete proteome]
Taxonomic identifier443226 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Orotidine 5'-phosphate decarboxylase
PRO_0000134657

Regions

Region62 – 643Substrate binding By similarity
Region93 – 10210Substrate binding By similarity

Sites

Active site951Proton donor By similarity
Binding site401Substrate By similarity
Binding site2271Substrate By similarity
Binding site2451Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4VWW3 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 642F23A5FAC8CC20

FASTA27429,683
        10         20         30         40         50         60 
MASKSQFPYE DRARDHPNPL ARRLFQIATE KQSNVVVSAD VTTTKELLDL ADRLGPYMVV 

        70         80         90        100        110        120 
LKTHIDILAD FSAETITGLQ SLSQKHNFLI FEDRKFVDIG NTVQKQYHGG ALHISEWAHI 

       130        140        150        160        170        180 
VNATVLPGPG IIDALAQVAS APDFPHASDR GLLILATMTS KGSLATGQYT ELSVELARKY 

       190        200        210        220        230        240 
KGFVLGFVAS RSLEGVETAG KADDEDFVLF TTGVNLASKG DALGQQYQTP ESAIGGGADF 

       250        260        270 
IISGRGIYAA PDPVDAARRY QKAGWDAYLK RVGR 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and confirmation of function of the Coccidioides posadasii URA3 (orotidine-5'-monophosphate decarboxylase) gene."
Chen X., Hung C.-Y., Cole G.T.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Coccidioides posadasii strain Silveira."
The Broad Institute Genome Sequencing Center for Infectious Disease
Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J., Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E. expand/collapse author list , Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.
Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RMSCC 757 / Silveira.
[3]"Concordance of gene genealogies reveals reproductive isolation in the pathogenic fungus Coccidioides immitis."
Koufopanou V., Burt A., Taylor J.W.
Proc. Natl. Acad. Sci. U.S.A. 94:5478-5482(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-201.
Strain: RMSCC 2233 / TX2, RMSCC 2343 / MX1 and RMSCC 757 / Silveira.
[4]Erratum
Koufopanou V., Burt A., Taylor J.W.
Proc. Natl. Acad. Sci. U.S.A. 95:8414-8414(1998)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY282521 Genomic DNA. Translation: AAQ16206.1.
GL636500 Genomic DNA. Translation: EFW15645.1.
AJ292100 Genomic DNA. Translation: CAC35044.1.
AJ292101 Genomic DNA. Translation: CAC35045.1.
AJ292102 Genomic DNA. Translation: CAC35046.1.

3D structure databases

ProteinModelPortalQ4VWW3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG7CVQ76.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_COCPS
AccessionPrimary (citable) accession number: Q4VWW3
Secondary accession number(s): E9DDC0, Q9C0T0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2005
Last modified: November 13, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways