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Protein
Submitted name:

Hexokinase

Gene

HK

Organism
Leishmania major
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
HexokinaseImported
Submitted name:
Putative hexokinaseImported (EC:2.7.1.1Imported)
Gene namesi
Name:HKImported
ORF Names:LMJF_21_0240Imported
OrganismiLeishmania majorImported
Taxonomic identifieri5664 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000000542: Chromosome 21

Structurei

3D structure databases

ProteinModelPortaliQ4VT70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000162670.
InParanoidiQ4VT70.
KOiK00844.
OMAiCALAANQ.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4VT70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAARVNNLLS HIAIRDSDSE EMRYIKQRLA LASLATQFTM SSEKMKQLTM
60 70 80 90 100
YMIHEMVEGL EGRPSTVRML PSFVYTSDPA KATGVYYALD LGGTNFRVLR
110 120 130 140 150
VSLRGGKVDD RTDSKFVIPK SALVGDATDL FDFIAQSVKK MMSENAPDDL
160 170 180 190 200
EKRVPLGFTF SFPVDQKAVN KGLLIKWTKG FSTKNVEGND VVELLQASLR
210 220 230 240 250
RVRVNVNVVA LCNDTVGTLV ARYFVDTDVQ VGVIIGTGSN ACYFERASAV
260 270 280 290 300
TKDPAVSARG NAVTPINMEC GNFDSKYKYA LPITVYDDEM DAITPNRENQ
310 320 330 340 350
RQEKLVSGMY LGEISRRLIV HLAQLGCLPR GLVDGLCRPW AFESKHMGMI
360 370 380 390 400
AADQMPGLQF TRELIKRIAG VDMADISDLH TIRETCCLVR NRAAQQGAVF
410 420 430 440 450
TAAPMLKTRT QGLATVAVDG SVYEKTPSFQ RLYQECITSI LGSTSNVKVV
460 470
LQRDGSGVGA AMICALAANT K
Length:471
Mass (Da):51,720
Last modified:July 5, 2005 - v1
Checksum:i5938CBED6934FC51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY632239 Genomic DNA. Translation: AAV32454.1.
FR796417 Genomic DNA. Translation: CAJ03833.1.
RefSeqiXP_001682957.1. XM_001682905.1.

Genome annotation databases

EnsemblProtistsiLmjF.21.0240:mRNA; LmjF.21.0240:pep; LmjF.21.0240.
GeneIDi5651558.
KEGGilma:LMJF_21_0240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY632239 Genomic DNA. Translation: AAV32454.1.
FR796417 Genomic DNA. Translation: CAJ03833.1.
RefSeqiXP_001682957.1. XM_001682905.1.

3D structure databases

ProteinModelPortaliQ4VT70.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiLmjF.21.0240:mRNA; LmjF.21.0240:pep; LmjF.21.0240.
GeneIDi5651558.
KEGGilma:LMJF_21_0240.

Phylogenomic databases

HOGENOMiHOG000162670.
InParanoidiQ4VT70.
KOiK00844.
OMAiCALAANQ.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the hexokinase gene from Leishmania major."
    Umasankar P.K., Jayakumar P.C., Shouche Y.S., Patole M.S.
    J. Parasitol. 91:1504-1509(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 309:436-442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported and MHOM/IL/81/FriedlinImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FriedlinImported.
  4. Aslett M.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: FriedlinImported.

Entry informationi

Entry nameiQ4VT70_LEIMA
AccessioniPrimary (citable) accession number: Q4VT70
Secondary accession number(s): Q4QCJ1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: February 4, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.