Q4VSN5 (DUSTY_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual serine/threonine and tyrosine protein kinase
EC=2.7.12.1

Alternative name(s):
Dusty protein kinase
Short name=Dusty PK
Receptor-interacting serine/threonine-protein kinase 5

Gene names

Name:	DSTYK
Synonyms:	RIPK5

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	930 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine/tyrosine kinase activity Inferred from electronic annotation. Source: EC protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 930	930	Dual serine/threonine and tyrosine protein kinase		PRO_0000233120
Regions
	Domain	653 – 907	255	Protein kinase
	Nucleotide binding	659 – 667	9	ATP By similarity
	Coiled coil	190 – 216	27	Potential
	Coiled coil	396 – 432	37	Potential
	Compositional bias	15 – 23	9	Poly-Gly
	Compositional bias	70 – 73	4	Poly-Gly
Sites
	Active site	778	1	Proton acceptor By similarity
	Binding site	682	1	ATP By similarity
Amino acid modifications
	Modified residue	929	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4VSN5 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 347812961CF5F68A	FASTA	930	105,305
	10 20 30 40 50 60 MEGDGVPWGS EPVSGPGPGG GGGMIRELCR GFGRYRRYLG RLRQNLRETQ KFFRDIKCSH 70 80 90 100 110 120 NHTCLSSLTG GGGAERGPAG DVAETGLQAG QLSCISFPPK EEKYLQQIVD CLPCILILGQ 130 140 150 160 170 180 DCNVKCQLLN LLLGVQVLPT TKLGSEESCK LRRLRFTYGT QTRVSLALPG QYELVHTLVA 190 200 210 220 230 240 HQGNWETIPE EDLEVQENNE DAAHVLAELE VTMHHALLQE VDVVVAPCQG LRPTVDVLGD 250 260 270 280 290 300 LVNDFLPVIT YALHKDELSE RDEQELQEIR KYFSFPVFFF KVPKLGSEII DSSTKRMESE 310 320 330 340 350 360 RSLLYRQLID LGYLSSSHWN CGAPGQDTKA QSMLVEQSEK LRHLSTFSHQ VLQTRLVDAA 370 380 390 400 410 420 KALNLVHCHC LDIFINQAFD MQRDLQITPK RLEYTRKKEN ELYESLMNIA NRKQEEMKDM 430 440 450 460 470 480 IVETLNTMKE ELLDDATNME FKDVIVPENG EPVGTREIKC CIRQIQELII SRLNQAVANK 490 500 510 520 530 540 LISSVDYLRE SFVGTLERCL QSLEKSQDVS VHITSNYLKQ ILNAAYHVEV TFHSGSSVTR 550 560 570 580 590 600 MLWEQIKQII QRITWVSPPA ITLEWKRKVA QEAIESLSAS KLAKSICSQF RTRLNSSHEA 610 620 630 640 650 660 FAASLRQLEA GHSGRLEKTE DLWLRVRKDH APRLARLSLE SRSLQDVLLH RKPKLGQELG 670 680 690 700 710 720 RGQYGVVYLC DNWGGHFPCA LKSVVPPDEK HWNDLALEFH YMRSLPKHER LVDLHGSVID 730 740 750 760 770 780 YNYGGGSSIA VLLIMERLHR DLYTGLKAGL TLETRLQIAL DVVEGIRFLH SQGLVHRDIK 790 800 810 820 830 840 LKNVLLDKQN RAKITDLGFC KPEAMMSGSI VGTPIHMAPE LFTGKYDNSV DVYAFGILFW 850 860 870 880 890 900 YICSGSVKLP EAFERCASKD HLWNNVRRGA RPERLPVFDE ECWQLMEACW DGDPLKRPLL 910 920 930 GIVQPMLQGI MDRLCKSNSE QPNRGLDDST

References

[1]

"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain." Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H. Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY641092 mRNA. Translation: AAV40858.1.
RefSeq	NP_001029338.1. NM_001034166.1.
UniGene	Ptr.6204.
3D structure databases
ProteinModelPortal	Q4VSN5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4VSN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000003448; ENSPTRP00000003173; ENSPTRG00000001895.
GeneID	457666.
KEGG	ptr:457666.
Organism-specific databases
CTD	25778.
Phylogenomic databases
eggNOG	prNOG16330.
GeneTree	ENSGT00600000084126.
InParanoid	Q4VSN5.
OMA	AGQLSCI.
OrthoDB	EOG4CNQQC.
PhylomeDB	Q4VSN5.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
KO	K08282.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSTY_PANTR

Accession

Primary (citable) accession number: Q4VSN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	July 5, 2005
Last modified:	November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program