Q4VSN4 (DUSTY_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual serine/threonine and tyrosine protein kinase
EC=2.7.12.1

Alternative name(s):
Dusty protein kinase
Short name=Dusty PK
Receptor-interacting serine/threonine-protein kinase 5

Gene names

Name:	DSTYK
Synonyms:	RIPK5

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	931 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine/tyrosine kinase activity Inferred from electronic annotation. Source: EC protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 931	931	Dual serine/threonine and tyrosine protein kinase		PRO_0000233117
Regions
	Domain	654 – 908	255	Protein kinase
	Nucleotide binding	660 – 668	9	ATP By similarity
	Coiled coil	397 – 424	28	Potential
	Compositional bias	15 – 24	10	Poly-Gly
Sites
	Active site	779	1	Proton acceptor By similarity
	Binding site	683	1	ATP By similarity
Amino acid modifications
	Modified residue	930	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4VSN4 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 3C413FE8EE1C8725	FASTA	931	105,010
	10 20 30 40 50 60 MEGDAPQRVS ERVSGPGPGG GGGGMIRELC RGFGRHRRYL GQLRQNLRET QKFFRDIKCS 70 80 90 100 110 120 HSHSCPSSPA GGGAAELGPA GDVAEAPLPA GQLSCIAFPP KEEKYLQQIV DCLPCILILG 130 140 150 160 170 180 QDCNVKCQLL NLLLGVQVLP TTRLGSEENC KLRRLRFTYG TQTRVSLALP GQYELVHTLV 190 200 210 220 230 240 AHQGNWDTIP EEDLEVQEDS EDAAHVLAEL EVTMHHALLQ DVDIVVAPCQ GLRPAVDVLG 250 260 270 280 290 300 DLVNDFLPVI TYALHKDELS ERDEQELQEI RKYFSFPIFF FKVPKLGSEI IASSTRRTEN 310 320 330 340 350 360 ERSPLHHQLM DLGYLSSSHC NCGVPGQDTK AQSMLVEQSE KLRHLSTFSH QVLQTHLVDA 370 380 390 400 410 420 AKALNRVHCH CLDIFINQAF DMQRDLQITP KRLEYTRKKE NELYESLMNI ANRKQEEMKD 430 440 450 460 470 480 MICETLNTMK GELLDDAANM EFKDVIVPEN GEAVGTRELK CCIRQIQELI ISRLNQAVAN 490 500 510 520 530 540 KLISSVDYLR ESFVGTLERC LQSLEKSQDV SIHITSNYLK QILNAAYHVE VTFHSGSSVT 550 560 570 580 590 600 RMLWEQIKQI IQRITWVNPP TITLEWKRKV AQEAIDSLSA SKLAKSICSQ FRTRLNSSHE 610 620 630 640 650 660 AFAASLRQLE AGHSGRLENT EDLWLKVRKD HAPRLARLSL ESRSLQDVLL HRKPKLGQEL 670 680 690 700 710 720 GRGQYGVVYL CDNWGGHFPC ALKSVVPPDE KHWNDLALEF HYMRSLPKHE RLVDLHGSVI 730 740 750 760 770 780 DYNYGGGSSI AVLLIMERLH RDLYTGLKAG LTLETRLQIA LDVVEGIRFL HSQGLVHRDI 790 800 810 820 830 840 KLKNVLLDKQ NRAKITDLGF CKPEAMMSGS IVGTPIHMAP ELFTGKYDNS VDVYAFGILF 850 860 870 880 890 900 WYICSGSVKL PEAFERCASK DHLWNNVRRG ARPERLPVFD EECWQLMEAC WDGDPSQRPL 910 920 930 LGIVQPMLQG IMERLCKSNS ERPNTGLDDS T

References

[1]

"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain." Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H. Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY641093 mRNA. Translation: AAV40859.1.
RefSeq	NP_001020439.1. NM_001025268.1.
UniGene	Cfa.24101.
3D structure databases
ProteinModelPortal	Q4VSN4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	478942.
KEGG	cfa:478942.
Organism-specific databases
CTD	25778.
Phylogenomic databases
eggNOG	maNOG10451.
GeneTree	ENSGT00600000084126.
InParanoid	Q4VSN4.
OrthoDB	EOG4CNQQC.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
KO	K08282.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSTY_CANFA

Accession

Primary (citable) accession number: Q4VSN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	July 5, 2005
Last modified:	November 16, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program