Q4VSN3 (DUSTY_TETNG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dual serine/threonine and tyrosine protein kinase
EC=2.7.12.1

Alternative name(s):
Dusty protein kinase
Short name=Dusty PK
Receptor-interacting serine/threonine-protein kinase 5

Gene names

Name:	dstyk
Synonyms:	ripk5

Organism

Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)

Taxonomic identifier

99883 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Tetraodontiformes › Tetradontoidea › Tetraodontidae › Tetraodon

Protein attributes

Sequence length	922 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity. UniProtKB Q6XUX3
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB P16879
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine/tyrosine kinase activity Inferred from electronic annotation. Source: EC protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 922	922	Dual serine/threonine and tyrosine protein kinase		PRO_0000374058
Regions
	Domain	645 – 899	255	Protein kinase
	Nucleotide binding	651 – 659	9	ATP By similarity
Sites
	Active site	770	1	Proton acceptor By similarity
	Binding site	674	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4VSN3 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 63A04B6409935998	FASTA	922	103,531
	10 20 30 40 50 60 MEGHGAQRSS PLARDLTRAF TSYNKHTVLL KKNLKETHAF FREMRQNYSN TCASSTLSSD 70 80 90 100 110 120 SSSQETGQFS CISFPSHEEE FLRNTVGAAP YILVLGQDCA ARYQLLNCLL GDRLLPLGPE 130 140 150 160 170 180 AGQACHGGQG NVCKRRKLCF THGRQTRLSL ALPGQYELVH QLAANCGRWE TVPREDLEIL 190 200 210 220 230 240 DECEDPAHRQ AELEITLHHP LLQEAKVMVV PCPSVQPIEE ALEDCTRSVI PIILYAVNRD 250 260 270 280 290 300 SLSSEQVADL RKVKEILSFP VCYVRLPDAS AASAELGQRC EKDKSKLQKQ LLSRGLLGSL 310 320 330 340 350 360 SGNCSCGAPA QTAAPGAKPQ SVVGENFEKL HRILVPFTRQ VLQNQQVEAA SLLNGLHCRC 370 380 390 400 410 420 LDLFINQAFD MQRDLQITPR RLEYTREKEG ELFTSLMTIA NRKQEEMKDM IVETLGSMKE 430 440 450 460 470 480 QLLEDAANLE FTDIIVTTNG DPVTSKEIKS CIQQIQDLIV VRLNQAVANK LISSVDYLRE 490 500 510 520 530 540 SFVGTLERCL SSLEKSHIES SVHNITSNHL KQLLNAAYHV EVTFHSGSSV TRLFWEQIKQ 550 560 570 580 590 600 IIHRITFVNP PAITPEWKRK VAQDAIESLS AAKLARSICS QFRTRLYSSH EAFAASLRQL 610 620 630 640 650 660 EERHTGRLER TEDLWLRVRK DHAPRLARLS LESRSLRDVV LHGKPKLGRE LGRGQYGVVY 670 680 690 700 710 720 LCDSWGGHNP CALKSVVPPD DKHWNDLALE FHYTRTLPKH ERLVDLHGSV IDHTYAGGSS 730 740 750 760 770 780 IAVLLIMERL HRDLYTGLKA GLSLQERLQI ALDVVEGIRF LHSQGLLHRD IKLKNVLLDK 790 800 810 820 830 840 QNRAKITDLG FCKPEAMMSG SIVGTPIHMA PELFTGKYDN SVDVYAFGIL FWYLCAGSVK 850 860 870 880 890 900 LPEAFEKCSS KDQLWNNVRK GARPERLPCF DEECWQLMEA CWNGDPSQRP LLGIVEPSLE 910 920 SITVRMCNCG SEQKSSSLED SC

References

[1]

"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain." Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H. Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY641094 mRNA. Translation: AAV40860.1.
3D structure databases
ProteinModelPortal	Q4VSN3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSTNIT00000002065; ENSTNIP00000000837; ENSTNIG00000014651.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSTY_TETNG

Accession

Primary (citable) accession number: Q4VSN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	July 5, 2005
Last modified:	October 19, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program