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Q4VSN1 (DUSTY_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dual serine/threonine and tyrosine protein kinase
EC=2.7.12.1
Alternative name(s):
Dusty protein kinase
Short name=Dusty PK
Receptor-interacting serine/threonine-protein kinase 5
Gene names
Name:dstyk
Synonyms:ripk5
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q4VSN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q4VSN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     483-510: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 885885Dual serine/threonine and tyrosine protein kinase
PRO_0000233123

Regions

Domain614 – 868255Protein kinase
Nucleotide binding620 – 6289ATP By similarity
Compositional bias252 – 2565Poly-Gly

Sites

Active site7391Proton acceptor By similarity
Binding site6431ATP By similarity

Natural variations

Alternative sequence483 – 51028Missing in isoform 2.
VSP_018040

Experimental info

Sequence conflict4671P → L in AAP42423. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 86F5AF552ABEA160

FASTA88599,548
        10         20         30         40         50         60 
MENPQKPREL TRAFNHYNKH SGFLKKNLKE TILFFREIRQ NHSNTCAAAE PGQLSCISFP 

        70         80         90        100        110        120 
RQDEEYLQNV VSSAPYILIL GQDCSARYQL LNCLLGERLL PLGPEAGGAC GAEGGACRRR 

       130        140        150        160        170        180 
KLCFTHGRQT RLSLALPGQY ELVHQLAAHC GRWDTVPRQD LEIQECEDPA QRLAELEITL 

       190        200        210        220        230        240 
HHTLLQEVKI MVLPCRNVQP LEEALEDCKR GILPIVLYAV SRESLSAQQL EDLQTLRESL 

       250        260        270        280        290        300 
PFPVCFIRVS DGGGGGALFT QLASLQLISA SAGNCACGAP AAQSAGRMQG VLCDSLERLQ 

       310        320        330        340        350        360 
RVLVPFTRQV LQNQQVEAAT LLNTIHCRCL DLFIIQAFDM QRDLQITPRR LEYTREKEGE 

       370        380        390        400        410        420 
LFCSLMAIAN RKQEEMKEMI VETLSSMKEQ LLEDAQNLDF TDIIMSSNGE PVSSKDIKVC 

       430        440        450        460        470        480 
ISQIQDLIVN RLNQAVANKL TNSVDYLRES FVGTLERCLG SLEKSTPESC AHNVTSNHLK 

       490        500        510        520        530        540 
QILNAAYHVE VTFHSGSSVT RLFWEQIKQI IHRITWVNPP AITAEWKRKV AQDAIESLSA 

       550        560        570        580        590        600 
AKLAKSICSQ FRTRLNSSHE AFAASLRQLE EGHTGRLERT EDLWLRVRKD HAPRLARLSL 

       610        620        630        640        650        660 
ESRSLRDILL HGKPKLGREL GRGQYGVVYL CDSWAGRHPC ALKSVVPPDD KHWNDLALEF 

       670        680        690        700        710        720 
HYTRSLPKHE RLVNLHGSVI DHSYSGGSSI AVLLIMERLH RDLYTGLKAG LSLKERLLIA 

       730        740        750        760        770        780 
LDVVEGIRFL HSQGLLHRDI KLKNVLLDKQ NRAKITDLGF CKPEAMMSGS IVGTPIHMAP 

       790        800        810        820        830        840 
ELFTGKYDNS VDVYAFGILF WYLCSGSVKL PEAFEKCASK DQLWTNVKKG CRPERLPVFD 

       850        860        870        880 
EECWQLMEAC WNGDPSQRPL LGIVQPGLQS IMERLCGEKS LEDSN

« Hide

Isoform 2 [UniParc].

Checksum: D016FCF6BB12BC40
Show »

FASTA85796,305

References

« Hide 'large scale' references
[1]"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain."
Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H.
Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY208855 mRNA. Translation: AAP42423.1.
AY429681 mRNA. Translation: AAS55397.1.
AY641096 mRNA. Translation: AAV40862.1.
BC067573 mRNA. Translation: AAH67573.1.
BC118677 mRNA. Translation: AAI18678.1.
IPIIPI00482647.
IPI00488458.
RefSeqNP_991190.2. NM_205627.2.
UniGeneDr.76381.

3D structure databases

ProteinModelPortalQ4VSN1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ4VSN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000067637; ENSDARP00000067636; ENSDARG00000000853.
ENSDART00000106645; ENSDARP00000097423; ENSDARG00000000853.
GeneID402922.
KEGGdre:402922.

Organism-specific databases

CTD25778.
ZFINZDB-GENE-040826-2. dstyk.

Phylogenomic databases

eggNOGfiNOG12756.
GeneTreeENSGT00600000084126.
InParanoidQ4VSN1.
OMAFDMARDM.
OrthoDBEOG4CNQQC.

Gene expression databases

BgeeQ4VSN1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
KOK08282.
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUSTY_DANRE
AccessionPrimary (citable) accession number: Q4VSN1
Secondary accession number(s): Q0VFW4 expand/collapse secondary AC list , Q5VJL5, Q6NWI9, Q6XUW8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2005
Last modified: November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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