Q4VQI2 (Q4VQI2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Potassium channel subfamily K member 2 Ensembl ENSMUSP00000078416

Submitted name:
TREK1 EMBL AAV48996.1

Gene names

Name:

Kcnk2 MGI 109366 Ensembl ENSMUSP00000078416

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification] RuleBase RU003857

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS013099
Molecular function	Ion channel SAAS SAAS013099 RuleBase RU003857
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from direct assay PubMed 11560940. Source: MGI stabilization of membrane potential Traceable author statement PubMed 11560940. Source: MGI
Cellular_component	voltage-gated potassium channel complex Inferred from direct assay PubMed 11560940. Source: MGI
Molecular_function	voltage-gated potassium channel activity Inferred from direct assay PubMed 11560940. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q4VQI2 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 8C298C01F5BDB61A	FASTA	426	46,844
	10 20 30 40 50 60 MLASASRERP GYTAGVAAPD LLDPKSAAQN SKPRLSFSSK PTVLASRVES DSAINVMKWK 70 80 90 100 110 120 TVSTIFLVVV LYLIIGATVF KALEQPQEIS QRTTIVIQKQ TFIAQHACVN STELDELIQQ 130 140 150 160 170 180 IVAAINAGII PLGNSSNQVS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL 190 200 210 220 230 240 GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL 250 260 270 280 290 300 PAVIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF 310 320 330 340 350 360 AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS 370 380 390 400 410 420 VKRKLSAELA GNHNQELTPC RRTLSVNHLT SEREVLPPLL KAESIYLNGL TPHCAGEDIA VIENMK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Desensitization of mechano-gated K2P channels." Honore E., Patel A.J., Chemin J., Suchyna T., Sachs F. Proc. Natl. Acad. Sci. U.S.A. 103:6859-6864(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/c EMBL AAV48996.1.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000078416.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000078416.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC121882 Genomic DNA. No translation available. AC124527 Genomic DNA. No translation available. AY736359 mRNA. Translation: AAV48996.1.
IPI	IPI00312558.
RefSeq	NP_001153322.1. NM_001159850.1.
UniGene	Mm.33304.
3D structure databases
SMR	Q4VQI2. Positions 76-318.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4050407.
STRING	10090.ENSMUSP00000106545.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000079451; ENSMUSP00000078416; ENSMUSG00000037624.
GeneID	16526.
KEGG	mmu:16526.
UCSC	uc007eak.2. mouse.
Organism-specific databases
CTD	3776.
MGI	MGI:109366. Kcnk2.
Phylogenomic databases
GeneTree	ENSGT00650000092968.
HOGENOM	HOG000013106.
HOVERGEN	HBG052234.
KO	K04913.
OMA	AINVMKW.
Gene expression databases
Genevestigator	Q4VQI2.
Family and domain databases
InterPro	IPR003280. 2pore_dom_K_chnl. IPR003976. 2pore_dom_K_chnl_TREK. IPR013099. Ion_trans_2. [Graphical view]
Pfam	PF07885. Ion_trans_2. 2 hits. [Graphical view]
PRINTS	PR01333. 2POREKCHANEL. PR01499. TREKCHANNEL.
ProtoNet	Search...
Other
NextBio	289923.
SOURCE	Search...

Entry information

Entry name

Q4VQI2_MOUSE

Accession

Primary (citable) accession number: Q4VQI2

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)