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Q4VNC1

- AT134_HUMAN

UniProt

Q4VNC1 - AT134_HUMAN

Protein

Probable cation-transporting ATPase 13A4

Gene

ATP13A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei486 – 48614-aspartylphosphate intermediateBy similarity
    Metal bindingi848 – 8481MagnesiumBy similarity
    Metal bindingi852 – 8521MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cation-transporting ATPase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cation-transporting ATPase 13A4 (EC:3.6.3.-)
    Alternative name(s):
    P5-ATPase isoform 4
    Gene namesi
    Name:ATP13A4
    ORF Names:UNQ3052/PRO9871
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25422. ATP13A4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv3(q25;q29). The inversion produces a disruption of the protein.

    Organism-specific databases

    PharmGKBiPA134979581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11961196Probable cation-transporting ATPase 13A4PRO_0000318675Add
    BLAST

    Proteomic databases

    PaxDbiQ4VNC1.
    PRIDEiQ4VNC1.

    PTM databases

    PhosphoSiteiQ4VNC1.

    Expressioni

    Tissue specificityi

    Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen.1 Publication

    Inductioni

    Decreased by half in the SLI patient lymphoblasts.1 Publication

    Gene expression databases

    ArrayExpressiQ4VNC1.
    BgeeiQ4VNC1.
    CleanExiHS_ATP13A4.
    GenevestigatoriQ4VNC1.

    Organism-specific databases

    HPAiHPA051932.

    Interactioni

    Protein-protein interaction databases

    IntActiQ4VNC1. 1 interaction.
    STRINGi9606.ENSP00000339182.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4VNC1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini53 – 197145ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 2235CytoplasmicSequence Analysis
    Topological domaini245 – 400156ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini422 – 43615CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini458 – 900443ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini922 – 93211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini954 – 97219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini994 – 103542CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1057 – 107014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1092 – 110918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1131 – 119666ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei901 – 92121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei933 – 95321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei973 – 99321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1036 – 105621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1071 – 109121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1110 – 113021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000171813.
    HOVERGENiHBG065757.
    InParanoidiQ4VNC1.
    KOiK14951.
    OMAiINVCGQL.
    PhylomeDBiQ4VNC1.
    TreeFamiTF300331.

    Family and domain databases

    Gene3Di2.70.150.10. 1 hit.
    3.40.1110.10. 1 hit.
    3.40.50.1000. 2 hits.
    InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
    IPR006544. ATPase_P-typ_Cation_typ_V.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF12409. P5-ATPase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01494. ATPase_P-type. 3 hits.
    TIGR01657. P-ATPase-V. 1 hit.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q4VNC1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGHFEKGQHA LLNEGEENEM EIFGYRTQGC RKSLCLAGSI FSFGILPLVF     50
    YWRPAWHVWA HCVPCSLQEA DTVLLRTTDE FQIYSWKKVI WIYLSALNSA 100
    FGLTPDHPLM TDEEYIINRA IRKPDLKVRC IKVQKIRYVW NYLEGQFQKI 150
    GSLEDWLSSA KIHQKFGSGL TREEQEIRRL ICGPNTIDVE VTPIWKLLIK 200
    EVLNPFYIFQ LFSVCLWFSE DYKEYAFAII IMSIISISLT VYDLREQSVK 250
    LHHLVESHNS ITVSVCGRKA GVQELESRVL VPGDLLILTG NKVLMPCDAV 300
    LIEGSCVVDE GMLTGESIPV TKTPLPKMDS SVPWKTQSEA DYKRHVLFCG 350
    TEVIQAKAAC SGTVRAVVLQ TGFNTAKGDL VRSILYPKPV NFQLYRDAIR 400
    FLLCLVGTAT IGMIYTLCVY VLSGEPPEEV VRKALDVITI AVPPALPAAL 450
    TTGIIYAQRR LKKRGIFCIS PQRINVCGQL NLVCFDKTGT LTRDGLDLWG 500
    VVSCDRNGFQ EVHSFASGQA LPWGPLCAAM ASCHSLILLD GTIQGDPLDL 550
    KMFEATTWEM AFSGDDFHIK GVPAHAMVVK PCRTASQVPV EGIAILHQFP 600
    FSSALQRMTV IVQEMGGDRL AFMKGAPERV ASFCQPETVP TSFVSELQIY 650
    TTQGFRVIAL AYKKLENDHH ATTLTRETVE SDLIFLGLLI LENRLKEETK 700
    PVLEELISAR IRTVMITGDN LQTAITVARK SGMVSESQKV ILIEANETTG 750
    SSSASISWTL VEEKKHIMYG NQDNYINIRD EVSDKGREGS YHFALTGKSF 800
    HVISQHFSSL LPKILINGTI FARMSPGQKS SLVEEFQKLD YFVGMCGDGA 850
    NDCGALKMAH VGISLSEQEA SVASPFTSKT PNIECVPHLI KEGRAALVTS 900
    FCMFKYMALY SMIQYVGVLL LYWETNSLSN YQFLFQDLAI TTLIGVTMNL 950
    NGAYPKLVPF RPAGRLISPP LLLSVIFNIL LSLAMHIAGF ILVQRQPWYS 1000
    VEIHSACTVQ NESISELTMS PTAPEKMESN STFTSFENTT VWFLGTINCI 1050
    TVALVFSKGK PFRQPTYTNY IFVLVLIIQL GVCLFILFAD IPELYRRLDL 1100
    LCTPVLWRAS IVIMLSLNFI VSLVAEEAVI ENRALWMMIK RCFGYQSKSQ 1150
    YRIWQRDLAN DPSWPPLNQT SHSDMPECGR GVSYSNPVFE SNEEQL 1196
    Length:1,196
    Mass (Da):133,987
    Last modified:May 18, 2010 - v3
    Checksum:i1D7F81F2BC266663
    GO
    Isoform 2 (identifier: Q4VNC1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         841-1196: Missing.

    Note: Dubious isoform lacking mature mRNA evidence.

    Show »
    Length:840
    Mass (Da):93,942
    Checksum:iDD58938371710B93
    GO
    Isoform 3 (identifier: Q4VNC1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         559-576: EMAFSGDDFHIKGVPAHA → VSLCSSENLRSFFNARAT
         577-1196: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:576
    Mass (Da):64,597
    Checksum:iA878E82DBC38293A
    GO
    Isoform 4 (identifier: Q4VNC1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-984: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:212
    Mass (Da):24,332
    Checksum:i05E159C0B52CB7A1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti840 – 8401D → E in BAC04520. (PubMed:14702039)Curated
    Sequence conflicti840 – 8401D → E in AAI01497. (PubMed:15489334)Curated
    Sequence conflicti975 – 9751V → A in AAX24102. (PubMed:15925480)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti181 – 1811I → M.1 Publication
    Corresponds to variant rs6788448 [ dbSNP | Ensembl ].
    VAR_038849
    Natural varianti353 – 3531V → A.1 Publication
    VAR_038850
    Natural varianti646 – 6461E → D.1 Publication
    Corresponds to variant rs35424709 [ dbSNP | Ensembl ].
    VAR_038851

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 984984Missing in isoform 4. 1 PublicationVSP_031258Add
    BLAST
    Alternative sequencei559 – 57618EMAFS…VPAHA → VSLCSSENLRSFFNARAT in isoform 3. 1 PublicationVSP_031259Add
    BLAST
    Alternative sequencei577 – 1196620Missing in isoform 3. 1 PublicationVSP_031260Add
    BLAST
    Alternative sequencei841 – 1196356Missing in isoform 2. 2 PublicationsVSP_031261Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY823162 mRNA. Translation: AAX24102.1.
    AY358110 mRNA. Translation: AAQ88477.1.
    AK095277 mRNA. Translation: BAC04520.1.
    AC048351 Genomic DNA. No translation available.
    AC092942 Genomic DNA. No translation available.
    AC105057 Genomic DNA. No translation available.
    BC101496 mRNA. Translation: AAI01497.1.
    AL512736 mRNA. Translation: CAC21667.2. Sequence problems.
    CCDSiCCDS3304.2. [Q4VNC1-1]
    RefSeqiNP_115655.2. NM_032279.2. [Q4VNC1-1]
    UniGeneiHs.674423.

    Genome annotation databases

    EnsembliENST00000295548; ENSP00000295548; ENSG00000127249. [Q4VNC1-3]
    ENST00000342695; ENSP00000339182; ENSG00000127249. [Q4VNC1-1]
    ENST00000400270; ENSP00000383129; ENSG00000127249. [Q4VNC1-4]
    GeneIDi84239.
    KEGGihsa:84239.
    UCSCiuc003ftd.3. human. [Q4VNC1-1]

    Polymorphism databases

    DMDMi296439435.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY823162 mRNA. Translation: AAX24102.1 .
    AY358110 mRNA. Translation: AAQ88477.1 .
    AK095277 mRNA. Translation: BAC04520.1 .
    AC048351 Genomic DNA. No translation available.
    AC092942 Genomic DNA. No translation available.
    AC105057 Genomic DNA. No translation available.
    BC101496 mRNA. Translation: AAI01497.1 .
    AL512736 mRNA. Translation: CAC21667.2 . Sequence problems.
    CCDSi CCDS3304.2. [Q4VNC1-1 ]
    RefSeqi NP_115655.2. NM_032279.2. [Q4VNC1-1 ]
    UniGenei Hs.674423.

    3D structure databases

    ProteinModelPortali Q4VNC1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q4VNC1. 1 interaction.
    STRINGi 9606.ENSP00000339182.

    PTM databases

    PhosphoSitei Q4VNC1.

    Polymorphism databases

    DMDMi 296439435.

    Proteomic databases

    PaxDbi Q4VNC1.
    PRIDEi Q4VNC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295548 ; ENSP00000295548 ; ENSG00000127249 . [Q4VNC1-3 ]
    ENST00000342695 ; ENSP00000339182 ; ENSG00000127249 . [Q4VNC1-1 ]
    ENST00000400270 ; ENSP00000383129 ; ENSG00000127249 . [Q4VNC1-4 ]
    GeneIDi 84239.
    KEGGi hsa:84239.
    UCSCi uc003ftd.3. human. [Q4VNC1-1 ]

    Organism-specific databases

    CTDi 84239.
    GeneCardsi GC03M193119.
    HGNCi HGNC:25422. ATP13A4.
    HPAi HPA051932.
    MIMi 609556. gene.
    neXtProti NX_Q4VNC1.
    PharmGKBi PA134979581.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000171813.
    HOVERGENi HBG065757.
    InParanoidi Q4VNC1.
    KOi K14951.
    OMAi INVCGQL.
    PhylomeDBi Q4VNC1.
    TreeFami TF300331.

    Miscellaneous databases

    GenomeRNAii 84239.
    NextBioi 73709.
    PROi Q4VNC1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q4VNC1.
    Bgeei Q4VNC1.
    CleanExi HS_ATP13A4.
    Genevestigatori Q4VNC1.

    Family and domain databases

    Gene3Di 2.70.150.10. 1 hit.
    3.40.1110.10. 1 hit.
    3.40.50.1000. 2 hits.
    InterProi IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR006544. ATPase_P-typ_Cation_typ_V.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF12409. P5-ATPase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01494. ATPase_P-type. 3 hits.
    TIGR01657. P-ATPase-V. 1 hit.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay."
      Kwasnicka-Crawford D.A., Carson A.R., Roberts W., Summers A.M., Rehnstrom K., Jarvela I., Scherer S.W.
      Genomics 86:182-194(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION, CHROMOSOMAL REARRANGEMENT, VARIANTS MET-181; ALA-353 AND ASP-646.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Tongue.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 287-1196 (ISOFORM 3).
      Tissue: Amygdala.

    Entry informationi

    Entry nameiAT134_HUMAN
    AccessioniPrimary (citable) accession number: Q4VNC1
    Secondary accession number(s): B7WPC7
    , Q6UY23, Q8N1Q9, Q9H043
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3