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Protein

Probable cation-transporting ATPase 13A5

Gene

ATP13A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei486 – 48614-aspartylphosphate intermediateBy similarity
Metal bindingi850 – 8501MagnesiumBy similarity
Metal bindingi854 – 8541MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A5 (EC:3.6.3.-)
Alternative name(s):
P5-ATPase isoform 5
Gene namesi
Name:ATP13A5
ORF Names:UNQ488/PRO1004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31789. ATP13A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei401 – 42121HelicalSequence analysisAdd
BLAST
Transmembranei433 – 45321HelicalSequence analysisAdd
BLAST
Transmembranei903 – 92321HelicalSequence analysisAdd
BLAST
Transmembranei940 – 95617HelicalSequence analysisAdd
BLAST
Transmembranei973 – 99321HelicalSequence analysisAdd
BLAST
Transmembranei1042 – 106221HelicalSequence analysisAdd
BLAST
Transmembranei1077 – 109721HelicalSequence analysisAdd
BLAST
Transmembranei1115 – 113521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134952038.

Polymorphism and mutation databases

BioMutaiATP13A5.
DMDMi74753861.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12181218Probable cation-transporting ATPase 13A5PRO_0000337122Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi540 – 5401N-linked (GlcNAc...)Sequence analysis
Glycosylationi669 – 6691N-linked (GlcNAc...)Sequence analysis
Glycosylationi819 – 8191N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4VNC0.
PRIDEiQ4VNC0.

PTM databases

iPTMnetiQ4VNC0.
PhosphoSiteiQ4VNC0.

Expressioni

Gene expression databases

BgeeiQ4VNC0.
CleanExiHS_ATP13A5.
ExpressionAtlasiQ4VNC0. baseline and differential.
GenevisibleiQ4VNC0. HS.

Organism-specific databases

HPAiHPA031771.
HPA031774.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341942.

Structurei

3D structure databases

ProteinModelPortaliQ4VNC0.
SMRiQ4VNC0. Positions 144-922.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi462 – 4654Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ4VNC0.
KOiK14951.
OMAiTTEQHFW.
OrthoDBiEOG7B5WV2.
PhylomeDBiQ4VNC0.
TreeFamiTF300331.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4VNC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEENSKKDHR ALLNQGEEDE LEVFGYRDHN VRKAFCLVAS VLTCGGLLLV
60 70 80 90 100
FYWRPQWRVW ANCIPCPLQE ADTVLLRTTD EFQRYMRKKV FCLYLSTLKF
110 120 130 140 150
PVSKKWEESL VADRHSVINQ ALIKPELKLR CMEVQKIRYV WNDLEKRFQK
160 170 180 190 200
VGLLEDSNSC SDIHQTFGLG LTSEEQEVRR LVCGPNAIEV EIQPIWKLLV
210 220 230 240 250
KQVLNPFYVF QAFTLTLWLS QGYIEYSVAI IILTVISIVL SVYDLRQQSV
260 270 280 290 300
KLHNLVEDHN KVQVTIIVKD KGLEELESRL LVPGDILILP GKFSLPCDAV
310 320 330 340 350
LIDGSCVVNE GMLTGESIPV TKTPLPQMEN TMPWKCHSLE DYRKHVLFCG
360 370 380 390 400
TEVIQVKPSG QGPVRAVVLQ TGYNTAKGDL VRSILYPRPL NFKLYSDAFK
410 420 430 440 450
FIVFLACLGV MGFFYALGVY MYHGVPPKDT VTMALILLTV TVPPVLPAAL
460 470 480 490 500
TIGNVYAQKR LKKKKIFCIS PQRINMCGQI NLVCFDKTGT LTEDGLDLWG
510 520 530 540 550
TVPTADNCFQ EAHSFASGQA VPWSPLCAAM ASCHSLILLN GTIQGDPLDL
560 570 580 590 600
KMFEGTAWKM EDCIVDSCKF GTSVSNIIKP GPKASKSPVE AIITLCQFPF
610 620 630 640 650
SSSLQRMSVI AQLAGENHFH VYMKGAPEMV ARFCRSETVP KNFPQELRSY
660 670 680 690 700
TVQGFRVIAL AHKTLKMGNL SEVEHLAREK VESELTFLGL LIMENRLKKE
710 720 730 740 750
TKLVLKELSE ARIRTVMITG DNLQTAITVA KNSEMIPPGS QVIIVEADEP
760 770 780 790 800
EEFVPASVTW QLVENQETGP GKKEIYMHTG NSSTPRGEGG SCYHFAMSGK
810 820 830 840 850
SYQVIFQHFN SLLPKILVNG TVFARMSPGQ KSSLIEEFQK LNYYVGMCGD
860 870 880 890 900
GANDCGALKA AHAGISLSEQ EASVASPFTS KTTNIQCVPH LIREGRAALV
910 920 930 940 950
SSFGVFKYLT MYGIIQFISA LLLYWQLQLF GNYQYLMQDV AITLMVCLTM
960 970 980 990 1000
SSTHAYPKLA PYRPAGQLLS PPLLLSIFLN SCFSCIVQIS AFLYVKQQPW
1010 1020 1030 1040 1050
YCEVYQYSEC FLANQSNFST NVSLERNWTG NATLIPGSIL SFETTTLWPI
1060 1070 1080 1090 1100
TTINYITVAF IFSKGKPFRK PIYTNYIFSF LLLAALGLTI FILFSDFQVI
1110 1120 1130 1140 1150
YRGMELIPTI TSWRVLILVV ALTQFCVAFF VEDSILQNHE LWLLIKREFG
1160 1170 1180 1190 1200
FYSKSQYRTW QKKLAEDSTW PPINRTDYSG DGKNGFYING GYESHEQIPK
1210
RKLKLGGQPT EQHFWARL
Length:1,218
Mass (Da):137,327
Last modified:July 5, 2005 - v1
Checksum:i70A58A83549DEE31
GO

Sequence cautioni

The sequence AAQ89030.1 differs from that shown. Reason: Frameshift at positions 1126 and 1135. Curated
The sequence AAQ89030.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85490.1 differs from that shown.Unlikely isoform. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti357 – 3571K → E in BAC85490 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961S → Y.1 Publication
Corresponds to variant rs12637558 [ dbSNP | Ensembl ].
VAR_061039
Natural varianti133 – 1331E → Q.
Corresponds to variant rs6797429 [ dbSNP | Ensembl ].
VAR_043614
Natural varianti739 – 7391G → S.
Corresponds to variant rs2280268 [ dbSNP | Ensembl ].
VAR_043615
Natural varianti1053 – 10531I → V.
Corresponds to variant rs6787746 [ dbSNP | Ensembl ].
VAR_043616
Natural varianti1131 – 11311V → A.1 Publication
Corresponds to variant rs2271791 [ dbSNP | Ensembl ].
VAR_043617
Natural varianti1204 – 12041K → Q.
Corresponds to variant rs7428010 [ dbSNP | Ensembl ].
VAR_043618

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823163 mRNA. Translation: AAX24103.1.
AK122613 mRNA. Translation: BAC85490.1. Sequence problems.
AY358667 mRNA. Translation: AAQ89030.1. Sequence problems.
CCDSiCCDS33914.1.
RefSeqiNP_940907.2. NM_198505.2.
UniGeneiHs.658032.

Genome annotation databases

EnsembliENST00000342358; ENSP00000341942; ENSG00000187527.
GeneIDi344905.
KEGGihsa:344905.
UCSCiuc011bsq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823163 mRNA. Translation: AAX24103.1.
AK122613 mRNA. Translation: BAC85490.1. Sequence problems.
AY358667 mRNA. Translation: AAQ89030.1. Sequence problems.
CCDSiCCDS33914.1.
RefSeqiNP_940907.2. NM_198505.2.
UniGeneiHs.658032.

3D structure databases

ProteinModelPortaliQ4VNC0.
SMRiQ4VNC0. Positions 144-922.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341942.

PTM databases

iPTMnetiQ4VNC0.
PhosphoSiteiQ4VNC0.

Polymorphism and mutation databases

BioMutaiATP13A5.
DMDMi74753861.

Proteomic databases

PaxDbiQ4VNC0.
PRIDEiQ4VNC0.

Protocols and materials databases

DNASUi344905.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342358; ENSP00000341942; ENSG00000187527.
GeneIDi344905.
KEGGihsa:344905.
UCSCiuc011bsq.3. human.

Organism-specific databases

CTDi344905.
GeneCardsiATP13A5.
HGNCiHGNC:31789. ATP13A5.
HPAiHPA031771.
HPA031774.
neXtProtiNX_Q4VNC0.
PharmGKBiPA134952038.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
GeneTreeiENSGT00530000063001.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ4VNC0.
KOiK14951.
OMAiTTEQHFW.
OrthoDBiEOG7B5WV2.
PhylomeDBiQ4VNC0.
TreeFamiTF300331.

Enzyme and pathway databases

ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

GenomeRNAii344905.
NextBioi98797.
PROiQ4VNC0.

Gene expression databases

BgeeiQ4VNC0.
CleanExiHS_ATP13A5.
ExpressionAtlasiQ4VNC0. baseline and differential.
GenevisibleiQ4VNC0. HS.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 1 hit.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay."
    Kwasnicka-Crawford D.A., Carson A.R., Roberts W., Summers A.M., Rehnstrom K., Jarvela I., Scherer S.W.
    Genomics 86:182-194(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1016, VARIANT TYR-96.
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1065-1218, VARIANT ALA-1131.

Entry informationi

Entry nameiAT135_HUMAN
AccessioniPrimary (citable) accession number: Q4VNC0
Secondary accession number(s): Q6UWS4, Q6ZWL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2005
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.