Reviewed, UniProtKB/Swiss-Prot Q4VK78 (ARGI2_RABIT)

Names and origin

Protein names

Recommended name:
    Arginase-2, mitochondrial
    EC=3.5.3.1
Alternative name(s):
    Type II arginase

Gene names

Name:

ARG2

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis By similarity.
Catalytic activity	L-arginine + H2O = L-ornithine + urea.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Pathway	Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Subunit structure	Homotrimer By similarity.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the arginase family.

Ontologies

Keywords
Biological process	Arginine metabolism Urea cycle
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW urea cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginase activity Inferred from electronic annotation. Source: EC manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 22	22	Mitochondrion Potential
	Chain	23 – 354	332	Arginase-2, mitochondrial		PRO_0000044614
Regions
	Region	145 – 149	5	Substrate binding By similarity
	Region	156 – 158	3	Substrate binding By similarity
Sites
	Metal binding	120	1	Manganese 1 By similarity
	Metal binding	143	1	Manganese 1 By similarity
	Metal binding	143	1	Manganese 2 By similarity
	Metal binding	145	1	Manganese 2 By similarity
	Metal binding	147	1	Manganese 1 By similarity
	Metal binding	251	1	Manganese 1 By similarity
	Metal binding	251	1	Manganese 2 By similarity
	Metal binding	253	1	Manganese 2 By similarity
	Binding site	202	1	Substrate By similarity
	Binding site	296	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4VK78-1 [UniParc]. Last modified July 5, 2005. Version 1. Checksum: 23313E232A8B6E8E	FASTA	354	38,393
	10 20 30 40 50 60 MSYGSCVSRL LRTRVQSVLK KSVHSVAVIG APFSQGQKRK GVECGPAAIR DAGLVKRLSD 70 80 90 100 110 120 LGCRLKDYGD LSFTPVPKDD LYNNLIVNPR SVGLANQELA EVVNRAVSGG YSCVTVGGDH 130 140 150 160 170 180 SLAIGTISGH ARHCPDLCVV WVDAHADINT PLTTSSGNLH GQPVSFLLRE LQDKVPQLPG 190 200 210 220 230 240 FSWIKPCISS PSIVYIGLRD VDPPEHFILK KYDIQYFSMR DIDRLGIQKV MEQTFDLLIG 250 260 270 280 290 300 KKQRPIHLSF DIDAFDPTLA PATGTPGCGG ADLSRRMYIS EEIHNTGLLS ALDLVEVNPR 310 320 330 340 350 LAASDEEAKA TASLAVDVIA SSFGQTREGG HTVYEQLPPP SSPHESENAE RVRI

References

[1]	"Chondrocyte phenotype-specific gene." Ah-Ra K., Yun Hyun H., Jang-Soo C. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY864853 mRNA. Translation: AAX58119.1.
RefSeq	NP_001075650.1.
UniGene	Ocu.3304
3D structure databases
SMR	Q4VK78. Positions 24-329.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4VK78.
Genome annotation databases
Ensembl	ENSOCUT00000000584; ENSOCUP00000000507; ENSOCUG00000000584; Oryctolagus cuniculus. [Genome view]
GeneID	100008967.
Phylogenomic databases
HOVERGEN	Q4VK78.
Enzyme and pathway databases
BRENDA	3.5.3.1. 255.
Family and domain databases
InterPro	IPR005924. Arginase. IPR014033. Arginase_sub. IPR006035. Ureohydrolase. IPR020855. Ureohydrolase_Mn_BS. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHER	PTHR11358:SF2. Arginase_sub. 1 hit. PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
PRINTS	PR00116. ARGINASE.
TIGRFAMs	TIGR01229. rocF_arginase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGI2_RABIT

Accession

Primary (citable) accession number: Q4VK78

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 5, 2005
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)