ID   IFNL2_MOUSE             Reviewed;         193 AA.
AC   Q4VK74; E9Q2S2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   24-JAN-2024, entry version 106.
DE   RecName: Full=Interferon lambda-2 {ECO:0000303|PubMed:15914836};
DE            Short=IFN-lambda-2 {ECO:0000303|PubMed:15914836};
DE   AltName: Full=Interleukin-28A {ECO:0000312|MGI:MGI:3647279};
DE            Short=IL-28A {ECO:0000250|UniProtKB:Q8IZJ0};
DE   Flags: Precursor;
GN   Name=Ifnl2; Synonyms=Il28a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAX58714.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=129/Sv {ECO:0000312|EMBL:AAX58714.1};
RX   PubMed=15914836; DOI=10.1099/vir.0.80904-0;
RA   Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.;
RT   "Murine interferon lambdas (type III interferons) exhibit potent antiviral
RT   activity in vivo in a poxvirus infection model.";
RL   J. Gen. Virol. 86:1589-1596(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=16618774; DOI=10.1158/0008-5472.can-05-3653;
RA   Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B.,
RA   Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E.,
RA   Kotenko S.V.;
RT   "Characterization of the mouse IFN-lambda ligand-receptor system: IFN-
RT   lambdas exhibit antitumor activity against B16 melanoma.";
RL   Cancer Res. 66:4468-4477(2006).
RN   [4]
RP   FUNCTION.
RX   PubMed=18250457; DOI=10.4049/jimmunol.180.4.2474;
RA   Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B.,
RA   Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K.,
RA   Paludan S.R.;
RT   "An important role for type III interferon (IFN-lambda/IL-28) in TLR-
RT   induced antiviral activity.";
RL   J. Immunol. 180:2474-2485(2008).
RN   [5]
RP   REVIEW.
RX   PubMed=20712453; DOI=10.1089/jir.2010.0078;
RA   Donnelly R.P., Kotenko S.V.;
RT   "Interferon-lambda: a new addition to an old family.";
RL   J. Interferon Cytokine Res. 30:555-564(2010).
RN   [6]
RP   FUNCTION.
RX   PubMed=21518880; DOI=10.1073/pnas.1100552108;
RA   Pott J., Mahlakoiv T., Mordstein M., Duerr C.U., Michiels T.,
RA   Stockinger S., Staeheli P., Hornef M.W.;
RT   "IFN-lambda determines the intestinal epithelial antiviral host defense.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:7944-7949(2011).
RN   [7]
RP   REVIEW.
RX   PubMed=24751921; DOI=10.1159/000360084;
RA   Hermant P., Michiels T.;
RT   "Interferon-lambda in the context of viral infections: production, response
RT   and therapeutic implications.";
RL   J. Innate Immun. 6:563-574(2014).
CC   -!- FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory
CC       activities. Plays a critical role in the antiviral host defense,
CC       predominantly in the epithelial tissues. Acts as a ligand for the
CC       heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1,
CC       and receptor engagement leads to the activation of the JAK/STAT
CC       signaling pathway resulting in the expression of IFN-stimulated genes
CC       (ISG), which mediate the antiviral state. Has a restricted receptor
CC       distribution and therefore restricted targets: is primarily active in
CC       epithelial cells and this cell type-selective action is because of the
CC       epithelial cell-specific expression of its receptor IFNLR1. Seems not
CC       to be essential for early virus-activated host defense in vaginal
CC       infection, but plays an important role in Toll-like receptor (TLR)-
CC       induced antiviral defense. Plays a significant role in the antiviral
CC       immune defense in the intestinal epithelium. Exerts an immunomodulatory
CC       effect by up-regulating MHC class I antigen expression.
CC       {ECO:0000269|PubMed:15914836, ECO:0000269|PubMed:16618774,
CC       ECO:0000269|PubMed:18250457, ECO:0000269|PubMed:21518880}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IZJ0}.
CC   -!- SIMILARITY: Belongs to the lambda interferon family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY869695; AAX58714.1; -; mRNA.
DR   EMBL; AC149606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS39861.1; -.
DR   RefSeq; NP_001019844.2; NM_001024673.2.
DR   AlphaFoldDB; Q4VK74; -.
DR   SMR; Q4VK74; -.
DR   STRING; 10090.ENSMUSP00000080384; -.
DR   GlyCosmos; Q4VK74; 1 site, No reported glycans.
DR   GlyGen; Q4VK74; 1 site.
DR   iPTMnet; Q4VK74; -.
DR   PhosphoSitePlus; Q4VK74; -.
DR   PaxDb; 10090-ENSMUSP00000080384; -.
DR   DNASU; 330496; -.
DR   Ensembl; ENSMUST00000081684.3; ENSMUSP00000080384.3; ENSMUSG00000059128.4.
DR   GeneID; 330496; -.
DR   KEGG; mmu:330496; -.
DR   UCSC; uc009fzd.1; mouse.
DR   AGR; MGI:3647279; -.
DR   CTD; 282616; -.
DR   MGI; MGI:3647279; Ifnl2.
DR   VEuPathDB; HostDB:ENSMUSG00000059128; -.
DR   eggNOG; ENOG502SSDC; Eukaryota.
DR   GeneTree; ENSGT00390000014310; -.
DR   HOGENOM; CLU_120266_0_0_1; -.
DR   InParanoid; Q4VK74; -.
DR   OMA; HWLQKLE; -.
DR   OrthoDB; 4612062at2759; -.
DR   PhylomeDB; Q4VK74; -.
DR   TreeFam; TF336172; -.
DR   Reactome; R-MMU-8854691; Interleukin-20 family signaling.
DR   BioGRID-ORCS; 330496; 4 hits in 76 CRISPR screens.
DR   PRO; PR:Q4VK74; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q4VK74; Protein.
DR   Bgee; ENSMUSG00000059128; Expressed in thymus and 1 other cell type or tissue.
DR   GO; GO:0005576; C:extracellular region; ISO:MGI.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0032002; C:interleukin-28 receptor complex; ISO:MGI.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0032003; F:interleukin-28 receptor binding; ISO:MGI.
DR   GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR   GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0002385; P:mucosal immune response; IDA:UniProtKB.
DR   GO; GO:0050778; P:positive regulation of immune response; IEA:InterPro.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:InterPro.
DR   Gene3D; 1.20.1250.60; Interferon lambda; 1.
DR   InterPro; IPR038326; IFN-lambda_sf.
DR   InterPro; IPR029177; INF_lambda.
DR   PANTHER; PTHR31943:SF1; INTERFERON LAMBDA-2-RELATED; 1.
DR   PANTHER; PTHR31943; INTERLEUKIN-28 AND 29; 1.
DR   Pfam; PF15177; IL28A; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..193
FT                   /note="Interferon lambda-2"
FT                   /id="PRO_0000345632"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        67
FT                   /note="L -> M (in Ref. 1; AAX58714)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        74..75
FT                   /note="FP -> IS (in Ref. 1; AAX58714)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        142..143
FT                   /note="RS -> KP (in Ref. 1; AAX58714)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        169
FT                   /note="A -> D (in Ref. 1; AAX58714)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        188
FT                   /note="N -> S (in Ref. 1; AAX58714)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   193 AA;  21740 MW;  42D7858FE245CC12 CRC64;
     MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKDAIEK
     RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL KVWENMTDSA LATILGQPLH
     TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR WLHRLQEAQS KETPGCLEAS VTSNLFRLLT
     RDLKCVANGD QCV
//