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Q4VK74 (IFNL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon lambda-2

Short name=IFN-lambda-2
Alternative name(s):
Interleukin-28A
Short name=IL-28A
Gene names
Name:Ifnl2
Synonyms:Il28a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Ref.1 Ref.3 Ref.4 Ref.5

Subcellular location

Secreted By similarity UniProtKB Q8IZJ0.

Sequence similarities

Belongs to the lambda interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to virus

Inferred from direct assay Ref.5. Source: UniProtKB

mucosal immune response

Inferred from direct assay Ref.5. Source: UniProtKB

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 193174Interferon lambda-2
PRO_0000345632

Amino acid modifications

Glycosylation1051N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict671L → M in AAX58714. Ref.1
Sequence conflict74 – 752FP → IS in AAX58714. Ref.1
Sequence conflict142 – 1432RS → KP in AAX58714. Ref.1
Sequence conflict1691A → D in AAX58714. Ref.1
Sequence conflict1881N → S in AAX58714. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q4VK74 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 42D7858FE245CC12

FASTA19321,740
        10         20         30         40         50         60 
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKDAIEK 

        70         80         90        100        110        120 
RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL KVWENMTDSA LATILGQPLH 

       130        140        150        160        170        180 
TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR WLHRLQEAQS KETPGCLEAS VTSNLFRLLT 

       190 
RDLKCVANGD QCV 

« Hide

References

« Hide 'large scale' references
[1]"Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model."
Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.
J. Gen. Virol. 86:1589-1596(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: 129/Sv.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma."
Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B., Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E., Kotenko S.V.
Cancer Res. 66:4468-4477(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity."
Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., Paludan S.R.
J. Immunol. 180:2474-2485(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"IFN-lambda determines the intestinal epithelial antiviral host defense."
Pott J., Mahlakoiv T., Mordstein M., Duerr C.U., Michiels T., Stockinger S., Staeheli P., Hornef M.W.
Proc. Natl. Acad. Sci. U.S.A. 108:7944-7949(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY869695 mRNA. Translation: AAX58714.1.
AC149606 Genomic DNA. No translation available.
CCDSCCDS39861.1.
RefSeqNP_001019844.2. NM_001024673.2.
UniGeneMm.454510.

3D structure databases

ProteinModelPortalQ4VK74.
SMRQ4VK74. Positions 35-193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000077473.

PTM databases

PhosphoSiteQ4VK74.

Proteomic databases

PRIDEQ4VK74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000081684; ENSMUSP00000080384; ENSMUSG00000059128.
GeneID330496.
KEGGmmu:330496.

Organism-specific databases

CTD282616.
MGIMGI:3647279. Ifnl2.

Phylogenomic databases

eggNOGNOG40189.
GeneTreeENSGT00390000014310.
HOGENOMHOG000232074.
HOVERGENHBG052108.
InParanoidQ4VK74.
KOK05447.
OMANWSCSSP.
OrthoDBEOG7F24V6.
PhylomeDBQ4VK74.
TreeFamTF336172.

Gene expression databases

GenevestigatorQ4VK74.

Family and domain databases

InterProIPR029177. INF_lambda.
[Graphical view]
PfamPF15177. IL28A. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio399419.
PROQ4VK74.
SOURCESearch...

Entry information

Entry nameIFNL2_MOUSE
AccessionPrimary (citable) accession number: Q4VK74
Secondary accession number(s): E9Q2S2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot