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Protein

Interferon lambda-2

Gene

Ifnl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.4 Publications

GO - Molecular functioni

GO - Biological processi

  • defense response to virus Source: UniProtKB
  • innate immune response Source: GO_Central
  • JAK-STAT cascade Source: InterPro
  • mucosal immune response Source: UniProtKB
  • positive regulation of immune response Source: InterPro
  • regulation of T cell activation Source: GO_Central

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-MMU-8854691 Interleukin-20 family signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-21 Publication
Short name:
IFN-lambda-21 Publication
Alternative name(s):
Interleukin-28AImported
Short name:
IL-28ABy similarity
Gene namesi
Name:Ifnl2
Synonyms:Il28a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3647279 Ifnl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000034563220 – 193Interferon lambda-2Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4VK74
PRIDEiQ4VK74

PTM databases

iPTMnetiQ4VK74
PhosphoSitePlusiQ4VK74

Expressioni

Gene expression databases

BgeeiENSMUSG00000059128

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080384

Structurei

3D structure databases

ProteinModelPortaliQ4VK74
SMRiQ4VK74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0IH Eukaryota
ENOG410ZDRD LUCA
GeneTreeiENSGT00390000014310
HOGENOMiHOG000232074
HOVERGENiHBG052108
InParanoidiQ4VK74
KOiK05447
OMAiSKPTTTW
OrthoDBiEOG091G0RUH
PhylomeDBiQ4VK74
TreeFamiTF336172

Family and domain databases

Gene3Di1.20.1250.60, 1 hit
InterProiView protein in InterPro
IPR038326 IFN-lambda_sf
IPR029177 INF_lambda
PANTHERiPTHR31943 PTHR31943, 1 hit
PfamiView protein in Pfam
PF15177 IL28A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4VK74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA
60 70 80 90 100
FKKAKDAIEK RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL
110 120 130 140 150
KVWENMTDSA LATILGQPLH TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR
160 170 180 190
WLHRLQEAQS KETPGCLEAS VTSNLFRLLT RDLKCVANGD QCV
Length:193
Mass (Da):21,740
Last modified:October 3, 2012 - v2
Checksum:i42D7858FE245CC12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67L → M in AAX58714 (PubMed:15914836).Curated1
Sequence conflicti74 – 75FP → IS in AAX58714 (PubMed:15914836).Curated2
Sequence conflicti142 – 143RS → KP in AAX58714 (PubMed:15914836).Curated2
Sequence conflicti169A → D in AAX58714 (PubMed:15914836).Curated1
Sequence conflicti188N → S in AAX58714 (PubMed:15914836).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY869695 mRNA Translation: AAX58714.1
AC149606 Genomic DNA No translation available.
CCDSiCCDS39861.1
RefSeqiNP_001019844.2, NM_001024673.2
UniGeneiMm.454510

Genome annotation databases

EnsembliENSMUST00000081684; ENSMUSP00000080384; ENSMUSG00000059128
GeneIDi330496
KEGGimmu:330496
UCSCiuc009fzd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIFNL2_MOUSE
AccessioniPrimary (citable) accession number: Q4VK74
Secondary accession number(s): E9Q2S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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