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Q4VK74

- IFNL2_MOUSE

UniProt

Q4VK74 - IFNL2_MOUSE

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Protein

Interferon lambda-2

Gene

Ifnl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.4 Publications

GO - Biological processi

  1. defense response to virus Source: UniProtKB
  2. JAK-STAT cascade Source: InterPro
  3. mucosal immune response Source: UniProtKB
  4. positive regulation of immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-21 Publication
Short name:
IFN-lambda-21 Publication
Alternative name(s):
Interleukin-28AImported
Short name:
IL-28ABy similarity
Gene namesi
Name:Ifnl2
Synonyms:Il28a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:3647279. Ifnl2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 193174Interferon lambda-2PRO_0000345632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ4VK74.

PTM databases

PhosphoSiteiQ4VK74.

Expressioni

Gene expression databases

GenevestigatoriQ4VK74.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077473.

Structurei

3D structure databases

ProteinModelPortaliQ4VK74.
SMRiQ4VK74. Positions 35-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40189.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ4VK74.
KOiK05447.
OMAiNWSCSSP.
OrthoDBiEOG7F24V6.
PhylomeDBiQ4VK74.
TreeFamiTF336172.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4VK74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA
60 70 80 90 100
FKKAKDAIEK RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL
110 120 130 140 150
KVWENMTDSA LATILGQPLH TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR
160 170 180 190
WLHRLQEAQS KETPGCLEAS VTSNLFRLLT RDLKCVANGD QCV
Length:193
Mass (Da):21,740
Last modified:October 3, 2012 - v2
Checksum:i42D7858FE245CC12
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671L → M in AAX58714. (PubMed:15914836)Curated
Sequence conflicti74 – 752FP → IS in AAX58714. (PubMed:15914836)Curated
Sequence conflicti142 – 1432RS → KP in AAX58714. (PubMed:15914836)Curated
Sequence conflicti169 – 1691A → D in AAX58714. (PubMed:15914836)Curated
Sequence conflicti188 – 1881N → S in AAX58714. (PubMed:15914836)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY869695 mRNA. Translation: AAX58714.1.
AC149606 Genomic DNA. No translation available.
CCDSiCCDS39861.1.
RefSeqiNP_001019844.2. NM_001024673.2.
UniGeneiMm.454510.

Genome annotation databases

EnsembliENSMUST00000081684; ENSMUSP00000080384; ENSMUSG00000059128.
GeneIDi330496.
KEGGimmu:330496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY869695 mRNA. Translation: AAX58714.1 .
AC149606 Genomic DNA. No translation available.
CCDSi CCDS39861.1.
RefSeqi NP_001019844.2. NM_001024673.2.
UniGenei Mm.454510.

3D structure databases

ProteinModelPortali Q4VK74.
SMRi Q4VK74. Positions 35-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077473.

PTM databases

PhosphoSitei Q4VK74.

Proteomic databases

PRIDEi Q4VK74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081684 ; ENSMUSP00000080384 ; ENSMUSG00000059128 .
GeneIDi 330496.
KEGGi mmu:330496.

Organism-specific databases

CTDi 282616.
MGIi MGI:3647279. Ifnl2.

Phylogenomic databases

eggNOGi NOG40189.
GeneTreei ENSGT00390000014310.
HOGENOMi HOG000232074.
HOVERGENi HBG052108.
InParanoidi Q4VK74.
KOi K05447.
OMAi NWSCSSP.
OrthoDBi EOG7F24V6.
PhylomeDBi Q4VK74.
TreeFami TF336172.

Miscellaneous databases

NextBioi 399419.
PROi Q4VK74.
SOURCEi Search...

Gene expression databases

Genevestigatori Q4VK74.

Family and domain databases

InterProi IPR029177. INF_lambda.
[Graphical view ]
Pfami PF15177. IL28A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model."
    Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.
    J. Gen. Virol. 86:1589-1596(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: 129/SvImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma."
    Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B., Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E., Kotenko S.V.
    Cancer Res. 66:4468-4477(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity."
    Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., Paludan S.R.
    J. Immunol. 180:2474-2485(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Interferon-lambda: a new addition to an old family."
    Donnelly R.P., Kotenko S.V.
    J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. Cited for: FUNCTION.
  7. "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
    Hermant P., Michiels T.
    J. Innate Immun. 6:563-574(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiIFNL2_MOUSE
AccessioniPrimary (citable) accession number: Q4VK74
Secondary accession number(s): E9Q2S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3