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Protein

Interferon lambda-2

Gene

Ifnl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.4 Publications

GO - Molecular functioni

GO - Biological processi

  • defense response to virus Source: UniProtKB
  • innate immune response Source: GO_Central
  • JAK-STAT cascade Source: InterPro
  • mucosal immune response Source: UniProtKB
  • positive regulation of immune response Source: InterPro
  • regulation of T cell activation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-21 Publication
Short name:
IFN-lambda-21 Publication
Alternative name(s):
Interleukin-28AImported
Short name:
IL-28ABy similarity
Gene namesi
Name:Ifnl2
Synonyms:Il28a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3647279. Ifnl2.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000034563220 – 193Interferon lambda-2Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4VK74.
PRIDEiQ4VK74.

PTM databases

iPTMnetiQ4VK74.
PhosphoSitePlusiQ4VK74.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080384.

Structurei

3D structure databases

ProteinModelPortaliQ4VK74.
SMRiQ4VK74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0IH. Eukaryota.
ENOG410ZDRD. LUCA.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ4VK74.
KOiK05447.
OMAiFPRPWDL.
OrthoDBiEOG091G0RUH.
PhylomeDBiQ4VK74.
TreeFamiTF336172.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4VK74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA
60 70 80 90 100
FKKAKDAIEK RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL
110 120 130 140 150
KVWENMTDSA LATILGQPLH TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR
160 170 180 190
WLHRLQEAQS KETPGCLEAS VTSNLFRLLT RDLKCVANGD QCV
Length:193
Mass (Da):21,740
Last modified:October 3, 2012 - v2
Checksum:i42D7858FE245CC12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67L → M in AAX58714 (PubMed:15914836).Curated1
Sequence conflicti74 – 75FP → IS in AAX58714 (PubMed:15914836).Curated2
Sequence conflicti142 – 143RS → KP in AAX58714 (PubMed:15914836).Curated2
Sequence conflicti169A → D in AAX58714 (PubMed:15914836).Curated1
Sequence conflicti188N → S in AAX58714 (PubMed:15914836).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY869695 mRNA. Translation: AAX58714.1.
AC149606 Genomic DNA. No translation available.
CCDSiCCDS39861.1.
RefSeqiNP_001019844.2. NM_001024673.2.
UniGeneiMm.454510.

Genome annotation databases

EnsembliENSMUST00000081684; ENSMUSP00000080384; ENSMUSG00000059128.
GeneIDi330496.
KEGGimmu:330496.
UCSCiuc009fzd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY869695 mRNA. Translation: AAX58714.1.
AC149606 Genomic DNA. No translation available.
CCDSiCCDS39861.1.
RefSeqiNP_001019844.2. NM_001024673.2.
UniGeneiMm.454510.

3D structure databases

ProteinModelPortaliQ4VK74.
SMRiQ4VK74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080384.

PTM databases

iPTMnetiQ4VK74.
PhosphoSitePlusiQ4VK74.

Proteomic databases

PaxDbiQ4VK74.
PRIDEiQ4VK74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081684; ENSMUSP00000080384; ENSMUSG00000059128.
GeneIDi330496.
KEGGimmu:330496.
UCSCiuc009fzd.1. mouse.

Organism-specific databases

CTDi282616.
MGIiMGI:3647279. Ifnl2.

Phylogenomic databases

eggNOGiENOG410J0IH. Eukaryota.
ENOG410ZDRD. LUCA.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ4VK74.
KOiK05447.
OMAiFPRPWDL.
OrthoDBiEOG091G0RUH.
PhylomeDBiQ4VK74.
TreeFamiTF336172.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiQ4VK74.
SOURCEiSearch...

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFNL2_MOUSE
AccessioniPrimary (citable) accession number: Q4VK74
Secondary accession number(s): E9Q2S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.