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Q4VK74

- IFNL2_MOUSE

UniProt

Q4VK74 - IFNL2_MOUSE

Protein

Interferon lambda-2

Gene

Ifnl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.4 Publications

    GO - Biological processi

    1. defense response to virus Source: UniProtKB
    2. JAK-STAT cascade Source: InterPro
    3. mucosal immune response Source: UniProtKB
    4. positive regulation of immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon lambda-21 Publication
    Short name:
    IFN-lambda-21 Publication
    Alternative name(s):
    Interleukin-28AImported
    Short name:
    IL-28ABy similarity
    Gene namesi
    Name:Ifnl2
    Synonyms:Il28a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:3647279. Ifnl2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 193174Interferon lambda-2PRO_0000345632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ4VK74.

    PTM databases

    PhosphoSiteiQ4VK74.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4VK74.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000077473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4VK74.
    SMRiQ4VK74. Positions 35-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the lambda interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40189.
    GeneTreeiENSGT00390000014310.
    HOGENOMiHOG000232074.
    HOVERGENiHBG052108.
    InParanoidiQ4VK74.
    KOiK05447.
    OMAiNWSCSSP.
    OrthoDBiEOG7F24V6.
    PhylomeDBiQ4VK74.
    TreeFamiTF336172.

    Family and domain databases

    InterProiIPR029177. INF_lambda.
    [Graphical view]
    PfamiPF15177. IL28A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4VK74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLLLPLLL AAVLTRTQAD PVPRATRLPV EAKDCHIAQF KSLSPKELQA    50
    FKKAKDAIEK RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL 100
    KVWENMTDSA LATILGQPLH TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR 150
    WLHRLQEAQS KETPGCLEAS VTSNLFRLLT RDLKCVANGD QCV 193
    Length:193
    Mass (Da):21,740
    Last modified:October 3, 2012 - v2
    Checksum:i42D7858FE245CC12
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671L → M in AAX58714. (PubMed:15914836)Curated
    Sequence conflicti74 – 752FP → IS in AAX58714. (PubMed:15914836)Curated
    Sequence conflicti142 – 1432RS → KP in AAX58714. (PubMed:15914836)Curated
    Sequence conflicti169 – 1691A → D in AAX58714. (PubMed:15914836)Curated
    Sequence conflicti188 – 1881N → S in AAX58714. (PubMed:15914836)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY869695 mRNA. Translation: AAX58714.1.
    AC149606 Genomic DNA. No translation available.
    CCDSiCCDS39861.1.
    RefSeqiNP_001019844.2. NM_001024673.2.
    UniGeneiMm.454510.

    Genome annotation databases

    EnsembliENSMUST00000081684; ENSMUSP00000080384; ENSMUSG00000059128.
    GeneIDi330496.
    KEGGimmu:330496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY869695 mRNA. Translation: AAX58714.1 .
    AC149606 Genomic DNA. No translation available.
    CCDSi CCDS39861.1.
    RefSeqi NP_001019844.2. NM_001024673.2.
    UniGenei Mm.454510.

    3D structure databases

    ProteinModelPortali Q4VK74.
    SMRi Q4VK74. Positions 35-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000077473.

    PTM databases

    PhosphoSitei Q4VK74.

    Proteomic databases

    PRIDEi Q4VK74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081684 ; ENSMUSP00000080384 ; ENSMUSG00000059128 .
    GeneIDi 330496.
    KEGGi mmu:330496.

    Organism-specific databases

    CTDi 282616.
    MGIi MGI:3647279. Ifnl2.

    Phylogenomic databases

    eggNOGi NOG40189.
    GeneTreei ENSGT00390000014310.
    HOGENOMi HOG000232074.
    HOVERGENi HBG052108.
    InParanoidi Q4VK74.
    KOi K05447.
    OMAi NWSCSSP.
    OrthoDBi EOG7F24V6.
    PhylomeDBi Q4VK74.
    TreeFami TF336172.

    Miscellaneous databases

    NextBioi 399419.
    PROi Q4VK74.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q4VK74.

    Family and domain databases

    InterProi IPR029177. INF_lambda.
    [Graphical view ]
    Pfami PF15177. IL28A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model."
      Bartlett N.W., Buttigieg K., Kotenko S.V., Smith G.L.
      J. Gen. Virol. 86:1589-1596(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: 129/SvImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma."
      Lasfar A., Lewis-Antes A., Smirnov S.V., Anantha S., Abushahba W., Tian B., Reuhl K., Dickensheets H., Sheikh F., Donnelly R.P., Raveche E., Kotenko S.V.
      Cancer Res. 66:4468-4477(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity."
      Ank N., Iversen M.B., Bartholdy C., Staeheli P., Hartmann R., Jensen U.B., Dagnaes-Hansen F., Thomsen A.R., Chen Z., Haugen H., Klucher K., Paludan S.R.
      J. Immunol. 180:2474-2485(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Interferon-lambda: a new addition to an old family."
      Donnelly R.P., Kotenko S.V.
      J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. Cited for: FUNCTION.
    7. "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
      Hermant P., Michiels T.
      J. Innate Immun. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiIFNL2_MOUSE
    AccessioniPrimary (citable) accession number: Q4VK74
    Secondary accession number(s): E9Q2S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 57 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3