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Protein

Taste receptor type 2 member 38

Gene

T2r38

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative taste receptor which may play a role in the perception of bitterness.Curated

Miscellaneous

Several bitter taste receptors are expressed in a single taste receptor cell.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 38
Short name:
T2R38
Alternative name(s):
Taste receptor type 2 member 26
Short name:
T2R26
Gene namesi
Name:T2r38Imported
Synonyms:Tas2r26
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560649. T2R38.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 54CytoplasmicSequence analysisAdd BLAST16
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 94ExtracellularSequence analysisAdd BLAST19
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 142CytoplasmicSequence analysisAdd BLAST27
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 198ExtracellularSequence analysisAdd BLAST35
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 243CytoplasmicSequence analysisAdd BLAST24
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 276ExtracellularSequence analysisAdd BLAST12
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 331CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002476571 – 331Taste receptor type 2 member 38Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4VHE7.

PTM databases

PhosphoSitePlusiQ4VHE7.

Expressioni

Tissue specificityi

Expressed in tongue, stomach and duodenum.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028969.

Structurei

3D structure databases

ProteinModelPortaliQ4VHE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor T2R family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH9N. Eukaryota.
ENOG410Z3YE. LUCA.
HOGENOMiHOG000041379.
HOVERGENiHBG098741.
InParanoidiQ4VHE7.
KOiK08474.
PhylomeDBiQ4VHE7.
TreeFamiTF335891.

Family and domain databases

CDDicd15025. 7tm_TAS2R38. 1 hit.
InterProiView protein in InterPro
IPR007960. T2R.
IPR030050. TAS2R38.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PTHR11394:SF86. PTHR11394:SF86. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4VHE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTLTPVLTV SYEAKISFLF LSVVEFAVGI MANAFIVLVN FWDMVKKQPL
60 70 80 90 100
NNCDIALLCL SITRLFLQGL LLLDAIQLAC FQQMKDPLSH NYQAILTLWM
110 120 130 140 150
SANQVSLWLA ACLSLLYCAK IVRFSHTFPL HLASWVSRRF LQMLLVALLF
160 170 180 190 200
SGVCTALCLW DFFSRSHTVV TSMLHMNNTE FNLQIEKLNF FYSFVFCNVG
210 220 230 240 250
SVPPSLVFLI SSGVLVISLG NHMRTMKSQT RGSRDPSLEA HVRAIIFLVS
260 270 280 290 300
FLCFYVVSFC AALISIPLLV LWHNKGGVMV CIGMMAACPS GHAAILISGN
310 320 330
AKLKKVIVTI LFWFQSRQKV RRVHKVLPRI L
Length:331
Mass (Da):37,233
Last modified:July 5, 2005 - v1
Checksum:iE435EDCB9AC664B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101S → I in AAR13355 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY916512 mRNA. Translation: AAX99135.1.
AY362746 Genomic DNA. Translation: AAR13355.1.
RefSeqiNP_001019856.1. NM_001024685.1.
UniGeneiRn.156466.

Genome annotation databases

GeneIDi500091.
KEGGirno:500091.
UCSCiRGD:1560649. rat.

Similar proteinsi

Entry informationi

Entry nameiT2R38_RAT
AccessioniPrimary (citable) accession number: Q4VHE7
Secondary accession number(s): Q67ES4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2005
Last modified: August 30, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families