ID   Q4VHE4_HUMAN            Unreviewed;       139 AA.
AC   Q4VHE4;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   RecName: Full=hyaluronan synthase {ECO:0000256|ARBA:ARBA00012207};
DE            EC=2.4.1.212 {ECO:0000256|ARBA:ARBA00012207};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAY52132.1};
RN   [1] {ECO:0000313|EMBL:AAY52132.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15731173; DOI=10.1182/blood-2004-10-3825;
RA   Adamia S., Reiman T., Crainie M., Mant M.J., Belch A.R., Pilarski L.M.;
RT   "Intronic splicing of hyaluronan synthase 1 (HAS1): a biologically relevant
RT   indicator of poor outcome in multiple myeloma.";
RL   Blood 105:4836-4844(2005).
CC   -!- PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004698}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the NodC/HAS family.
CC       {ECO:0000256|ARBA:ARBA00006782}.
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DR   EMBL; AY916556; AAY52132.1; -; mRNA.
DR   AlphaFoldDB; Q4VHE4; -.
DR   PeptideAtlas; Q4VHE4; -.
DR   OMA; CILRRDM; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006024; P:glycosaminoglycan biosynthetic process; IEA:UniProt.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR22913; HYALURONAN SYNTHASE; 1.
DR   PANTHER; PTHR22913:SF4; HYALURONAN SYNTHASE 1; 1.
DR   Pfam; PF03142; Chitin_synth_2; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   2: Evidence at transcript level;
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAY52132.1"
SQ   SEQUENCE   139 AA;  15884 MW;  C2D3E84CDE42A98A CRC64;
     REVMYTAFKA LGDSVDYVQV CDSDTRLDPM ALLELVRVLD EDPRVGAVGG DVRILNPLDS
     WVSFLSSLRY WVAFNVERAC QSYFHCVSCI SGPLGLYRNN LLQQFLEAWY NQKFLGTHCT
     FGDDRHLTNR MLSMGYATK
//