Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FLYWCH-type zinc finger-containing protein 1

Gene

FLYWCH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri116 – 174FLYWCH-type 1Add BLAST59
Zinc fingeri273 – 331FLYWCH-type 2Add BLAST59
Zinc fingeri421 – 479FLYWCH-type 3Add BLAST59
Zinc fingeri509 – 567FLYWCH-type 4Add BLAST59
Zinc fingeri600 – 658FLYWCH-type 5Add BLAST59

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FLYWCH-type zinc finger-containing protein 1
Gene namesi
Name:FLYWCH1
Synonyms:KIAA1552
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25404. FLYWCH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84256.
OpenTargetsiENSG00000059122.
PharmGKBiPA142671760.

Polymorphism and mutation databases

BioMutaiFLYWCH1.
DMDMi166217021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003144601 – 716FLYWCH-type zinc finger-containing protein 1Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Cross-linki393Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei503PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei696PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ4VC44.
PaxDbiQ4VC44.
PeptideAtlasiQ4VC44.
PRIDEiQ4VC44.

PTM databases

iPTMnetiQ4VC44.
PhosphoSitePlusiQ4VC44.

Expressioni

Gene expression databases

BgeeiENSG00000059122.
CleanExiHS_FLYWCH1.
ExpressionAtlasiQ4VC44. baseline and differential.
GenevisibleiQ4VC44. HS.

Organism-specific databases

HPAiHPA040753.
HPA041001.

Interactioni

Protein-protein interaction databases

BioGridi123983. 11 interactors.
IntActiQ4VC44. 21 interactors.
MINTiMINT-4937620.
STRINGi9606.ENSP00000399938.

Structurei

Secondary structure

1716
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi599 – 603Combined sources5
Turni604 – 606Combined sources3
Beta strandi607 – 612Combined sources6
Beta strandi615 – 622Combined sources8
Beta strandi627 – 631Combined sources5
Helixi632 – 634Combined sources3
Beta strandi642 – 646Combined sources5
Beta strandi649 – 652Combined sources4
Helixi662 – 670Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RPRNMR-A595-674[»]
ProteinModelPortaliQ4VC44.
SMRiQ4VC44.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ4VC44.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 245Poly-Glu4

Sequence similaritiesi

Contains 5 FLYWCH-type zinc fingers.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri116 – 174FLYWCH-type 1Add BLAST59
Zinc fingeri273 – 331FLYWCH-type 2Add BLAST59
Zinc fingeri421 – 479FLYWCH-type 3Add BLAST59
Zinc fingeri509 – 567FLYWCH-type 4Add BLAST59
Zinc fingeri600 – 658FLYWCH-type 5Add BLAST59

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J2VB. Eukaryota.
ENOG410YYIU. LUCA.
GeneTreeiENSGT00530000064166.
HOVERGENiHBG098123.
InParanoidiQ4VC44.
OMAiCVLSLEM.
OrthoDBiEOG091G0PRI.
PhylomeDBiQ4VC44.
TreeFamiTF337169.

Family and domain databases

InterProiIPR029279. FLYWCH_N.
IPR007588. Znf_FLYWCH.
[Graphical view]
PfamiPF04500. FLYWCH. 5 hits.
PF15423. FLYWCH_N. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4VC44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLPEPSEQE GESVKAGQEP SPKPGTDVIP AAPRKPREFS KLVLLTASDQ
60 70 80 90 100
DEDGVGSKPQ EVHCVLSLEM AGPATLASTL QILPVEEQGG VVQPALEMPE
110 120 130 140 150
QKCSKLDAAA PQSLEFLRTP FGGRLLVLES FLYKQEKAVG DKVYWKCRQH
160 170 180 190 200
AELGCRGRAI TRGLRATVMR GHCHAPDEQG LEARRQREKL PSLALPEGLG
210 220 230 240 250
EPQGPEGPGG RVEEPLEGVG PWQCPEEPEP TPGLVLSKPA LEEEEAPRAL
260 270 280 290 300
SLLSLPPKKR SILGLGQARP LEFLRTCYGG SFLVHESFLY KREKAVGDKV
310 320 330 340 350
YWTCRDHALH GCRSRAITQG QRVTVMRGHC HQPDMEGLEA RRQQEKAVET
360 370 380 390 400
LQAGQDGPGS QVDTLLRGVD SLLYRRGPGP LTLTRPRPRK RAKVEDQELP
410 420 430 440 450
TQPEAPDEHQ DMDADPGGPE FLKTPLGGSF LVYESFLYRR EKAAGEKVYW
460 470 480 490 500
TCRDQARMGC RSRAITQGRR VTVMRGHCHP PDLGGLEALR QREKRPNTAQ
510 520 530 540 550
RGSPGGPEFL KTPLGGSFLV YESFLYRREK AAGEKVYWTC RDQARMGCRS
560 570 580 590 600
RAITQGRRVM VMRRHCHPPD LGGLEALRQR EHFPNLAQWD SPDPLRPLEF
610 620 630 640 650
LRTSLGGRFL VHESFLYRKE KAAGEKVYWM CRDQARLGCR SRAITQGHRI
660 670 680 690 700
MVMRSHCHQP DLAGLEALRQ RERLPTTAQQ EDPEKIQVQL CFKTCSPESQ
710
QIYGDIKDVR LDGESQ
Length:716
Mass (Da):80,108
Last modified:January 15, 2008 - v2
Checksum:iBC1DD372CA925A72
GO
Isoform 2 (identifier: Q4VC44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-108: Missing.

Show »
Length:715
Mass (Da):80,037
Checksum:iFF6024A5B29CADBA
GO
Isoform 3 (identifier: Q4VC44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     504-504: P → PGAGLSFQWLFRILQLLGHAPVLLCPSGSSCLPSLPAPHGPCPALSIPLE

Show »
Length:765
Mass (Da):85,153
Checksum:iDF6068B9CB520511
GO
Isoform 4 (identifier: Q4VC44-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.

Show »
Length:391
Mass (Da):44,665
Checksum:iBC4C192159B5CD98
GO
Isoform 5 (identifier: Q4VC44-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-388: Missing.
     389-504: RKRAKVEDQE...RPNTAQRGSP → MPQATSPPLW...ADTASLKAWQ

Show »
Length:328
Mass (Da):36,821
Checksum:i96BE5A7C2B247109
GO

Sequence cautioni

The sequence BAB13378 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti666E → G in AAH28572 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0302771 – 388Missing in isoform 5. 1 PublicationAdd BLAST388
Alternative sequenceiVSP_0302781 – 325Missing in isoform 4. 1 PublicationAdd BLAST325
Alternative sequenceiVSP_030279108Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_030280389 – 504RKRAK…QRGSP → MPQATSPPLWPLSLHGGKGI LWARHSHPPGPPSHHIQDSG RCSLPLPQSPGVTPLPARLS GATPLSPIRLLSSFVPRGPR VIPLTNQARRTLHASLGGCW GRTSDAADTASLKAWQ in isoform 5. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_030281504P → PGAGLSFQWLFRILQLLGHA PVLLCPSGSSCLPSLPAPHG PCPALSIPLE in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046772 mRNA. Translation: BAB13378.1. Different initiation.
AK127235 mRNA. Translation: BAC86896.1.
CH471112 Genomic DNA. Translation: EAW85450.1.
CH471112 Genomic DNA. Translation: EAW85451.1.
BC001973 mRNA. Translation: AAH01973.1.
BC018712 mRNA. Translation: AAH18712.1.
BC028572 mRNA. Translation: AAH28572.1.
AL136585 mRNA. Translation: CAB66520.2.
CCDSiCCDS45390.1. [Q4VC44-2]
CCDS76809.1. [Q4VC44-1]
RefSeqiNP_001294997.1. NM_001308068.1. [Q4VC44-1]
NP_065963.1. NM_020912.1.
NP_115672.2. NM_032296.2. [Q4VC44-2]
XP_006721025.1. XM_006720962.3. [Q4VC44-3]
UniGeneiHs.655321.

Genome annotation databases

EnsembliENST00000253928; ENSP00000253928; ENSG00000059122. [Q4VC44-1]
ENST00000416288; ENSP00000399938; ENSG00000059122. [Q4VC44-2]
GeneIDi84256.
KEGGihsa:84256.
UCSCiuc002csc.4. human. [Q4VC44-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046772 mRNA. Translation: BAB13378.1. Different initiation.
AK127235 mRNA. Translation: BAC86896.1.
CH471112 Genomic DNA. Translation: EAW85450.1.
CH471112 Genomic DNA. Translation: EAW85451.1.
BC001973 mRNA. Translation: AAH01973.1.
BC018712 mRNA. Translation: AAH18712.1.
BC028572 mRNA. Translation: AAH28572.1.
AL136585 mRNA. Translation: CAB66520.2.
CCDSiCCDS45390.1. [Q4VC44-2]
CCDS76809.1. [Q4VC44-1]
RefSeqiNP_001294997.1. NM_001308068.1. [Q4VC44-1]
NP_065963.1. NM_020912.1.
NP_115672.2. NM_032296.2. [Q4VC44-2]
XP_006721025.1. XM_006720962.3. [Q4VC44-3]
UniGeneiHs.655321.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RPRNMR-A595-674[»]
ProteinModelPortaliQ4VC44.
SMRiQ4VC44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123983. 11 interactors.
IntActiQ4VC44. 21 interactors.
MINTiMINT-4937620.
STRINGi9606.ENSP00000399938.

PTM databases

iPTMnetiQ4VC44.
PhosphoSitePlusiQ4VC44.

Polymorphism and mutation databases

BioMutaiFLYWCH1.
DMDMi166217021.

Proteomic databases

MaxQBiQ4VC44.
PaxDbiQ4VC44.
PeptideAtlasiQ4VC44.
PRIDEiQ4VC44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253928; ENSP00000253928; ENSG00000059122. [Q4VC44-1]
ENST00000416288; ENSP00000399938; ENSG00000059122. [Q4VC44-2]
GeneIDi84256.
KEGGihsa:84256.
UCSCiuc002csc.4. human. [Q4VC44-1]

Organism-specific databases

CTDi84256.
DisGeNETi84256.
GeneCardsiFLYWCH1.
H-InvDBHIX0202242.
HGNCiHGNC:25404. FLYWCH1.
HPAiHPA040753.
HPA041001.
neXtProtiNX_Q4VC44.
OpenTargetsiENSG00000059122.
PharmGKBiPA142671760.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2VB. Eukaryota.
ENOG410YYIU. LUCA.
GeneTreeiENSGT00530000064166.
HOVERGENiHBG098123.
InParanoidiQ4VC44.
OMAiCVLSLEM.
OrthoDBiEOG091G0PRI.
PhylomeDBiQ4VC44.
TreeFamiTF337169.

Miscellaneous databases

EvolutionaryTraceiQ4VC44.
GenomeRNAii84256.
PROiQ4VC44.

Gene expression databases

BgeeiENSG00000059122.
CleanExiHS_FLYWCH1.
ExpressionAtlasiQ4VC44. baseline and differential.
GenevisibleiQ4VC44. HS.

Family and domain databases

InterProiIPR029279. FLYWCH_N.
IPR007588. Znf_FLYWCH.
[Graphical view]
PfamiPF04500. FLYWCH. 5 hits.
PF15423. FLYWCH_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFWCH1_HUMAN
AccessioniPrimary (citable) accession number: Q4VC44
Secondary accession number(s): D3DUA1
, Q6ZSQ1, Q8WV62, Q9BQG6, Q9BUS5, Q9HCM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.