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Protein

Coiled-coil domain-containing protein 58

Gene

CCDC58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 58
Gene namesi
Name:CCDC58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31136. CCDC58.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485410.

Polymorphism and mutation databases

BioMutaiCCDC58.
DMDMi74754617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 144143Coiled-coil domain-containing protein 58PRO_0000239441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei100 – 1001N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ4VC31.
MaxQBiQ4VC31.
PaxDbiQ4VC31.
PeptideAtlasiQ4VC31.
PRIDEiQ4VC31.
TopDownProteomicsiQ4VC31.

PTM databases

iPTMnetiQ4VC31.
PhosphoSiteiQ4VC31.

Expressioni

Gene expression databases

BgeeiQ4VC31.
CleanExiHS_CCDC58.
ExpressionAtlasiQ4VC31. baseline and differential.
GenevisibleiQ4VC31. HS.

Organism-specific databases

HPAiHPA047777.
HPA051965.

Interactioni

Protein-protein interaction databases

BioGridi126270. 10 interactions.
STRINGi9606.ENSP00000291458.

Structurei

3D structure databases

ProteinModelPortaliQ4VC31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili82 – 12039Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC58 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4613. Eukaryota.
ENOG4111KXF. LUCA.
GeneTreeiENSGT00390000011053.
HOGENOMiHOG000007601.
HOVERGENiHBG061586.
InParanoidiQ4VC31.
OMAiNSESTCR.
OrthoDBiEOG74N5JF.
PhylomeDBiQ4VC31.
TreeFamiTF324875.

Family and domain databases

InterProiIPR019171. Caffeine_induced_death_Cid2.
[Graphical view]
PfamiPF09774. Cid2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4VC31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGGVNC EEFAEFQELL KVMRTIDDRI VHELNTTVPT ASFAGKIDAS
60 70 80 90 100
QTCKQLYESL MAAHASRDRV IKNCIAQTSA VVKNLREERE KNLDDLTLLK
110 120 130 140
QLRKEQTKLK WMQSELNVEE VVNDRSWKVF NERCRIHFKP PKNE
Length:144
Mass (Da):16,620
Last modified:July 5, 2005 - v1
Checksum:iA78EE047DDD458C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 52PS → GG in AAI09379 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062725 mRNA. Translation: AAH62725.1.
BC109378 mRNA. Translation: AAI09379.1.
CCDSiCCDS33838.1.
RefSeqiNP_001017928.1. NM_001017928.3.
NP_001295255.1. NM_001308326.1.
UniGeneiHs.220594.

Genome annotation databases

EnsembliENST00000291458; ENSP00000291458; ENSG00000160124.
GeneIDi131076.
KEGGihsa:131076.
UCSCiuc003eey.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062725 mRNA. Translation: AAH62725.1.
BC109378 mRNA. Translation: AAI09379.1.
CCDSiCCDS33838.1.
RefSeqiNP_001017928.1. NM_001017928.3.
NP_001295255.1. NM_001308326.1.
UniGeneiHs.220594.

3D structure databases

ProteinModelPortaliQ4VC31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126270. 10 interactions.
STRINGi9606.ENSP00000291458.

PTM databases

iPTMnetiQ4VC31.
PhosphoSiteiQ4VC31.

Polymorphism and mutation databases

BioMutaiCCDC58.
DMDMi74754617.

Proteomic databases

EPDiQ4VC31.
MaxQBiQ4VC31.
PaxDbiQ4VC31.
PeptideAtlasiQ4VC31.
PRIDEiQ4VC31.
TopDownProteomicsiQ4VC31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291458; ENSP00000291458; ENSG00000160124.
GeneIDi131076.
KEGGihsa:131076.
UCSCiuc003eey.4. human.

Organism-specific databases

CTDi131076.
GeneCardsiCCDC58.
HGNCiHGNC:31136. CCDC58.
HPAiHPA047777.
HPA051965.
neXtProtiNX_Q4VC31.
PharmGKBiPA143485410.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4613. Eukaryota.
ENOG4111KXF. LUCA.
GeneTreeiENSGT00390000011053.
HOGENOMiHOG000007601.
HOVERGENiHBG061586.
InParanoidiQ4VC31.
OMAiNSESTCR.
OrthoDBiEOG74N5JF.
PhylomeDBiQ4VC31.
TreeFamiTF324875.

Miscellaneous databases

ChiTaRSiCCDC58. human.
GenomeRNAii131076.
PROiQ4VC31.

Gene expression databases

BgeeiQ4VC31.
CleanExiHS_CCDC58.
ExpressionAtlasiQ4VC31. baseline and differential.
GenevisibleiQ4VC31. HS.

Family and domain databases

InterProiIPR019171. Caffeine_induced_death_Cid2.
[Graphical view]
PfamiPF09774. Cid2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-100, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCD58_HUMAN
AccessioniPrimary (citable) accession number: Q4VC31
Secondary accession number(s): Q32LY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2005
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.