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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 18

Gene

Adamts18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Zinc; catalyticPROSITE-ProRule annotation
Active sitei437 – 4371PROSITE-ProRule annotation
Metal bindingi440 – 4401Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi446 – 4461Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • eye development Source: MGI
  • negative regulation of platelet aggregation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.030.

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 18 (EC:3.4.24.-)
Short name:
ADAM-TS 18
Short name:
ADAM-TS18
Short name:
ADAMTS-18
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2442600. Adamts18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4747Sequence analysisAdd
BLAST
Chaini48 – 12191172A disintegrin and metalloproteinase with thrombospondin motifs 18PRO_0000042164Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Disulfide bondi369 ↔ 420By similarity
Disulfide bondi395 ↔ 402By similarity
Disulfide bondi414 ↔ 493By similarity
Disulfide bondi453 ↔ 477By similarity
Disulfide bondi521 ↔ 546By similarity
Disulfide bondi532 ↔ 553By similarity
Disulfide bondi541 ↔ 572By similarity
Disulfide bondi566 ↔ 577By similarity
Disulfide bondi601 ↔ 638By similarity
Disulfide bondi605 ↔ 643By similarity
Disulfide bondi616 ↔ 628By similarity
Glycosylationi745 – 7451N-linked (GlcNAc...)Sequence analysis
Glycosylationi838 – 8381N-linked (GlcNAc...)Sequence analysis
Glycosylationi865 – 8651N-linked (GlcNAc...)Sequence analysis
Glycosylationi909 – 9091N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ4VC17.
PRIDEiQ4VC17.

PTM databases

PhosphoSiteiQ4VC17.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053399.
GenevisibleiQ4VC17. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090801.

Structurei

3D structure databases

ProteinModelPortaliQ4VC17.
SMRiQ4VC17. Positions 295-806, 998-1085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini293 – 498206Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini589 – 64456TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini931 – 99060TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini991 – 104959TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini1052 – 111665TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini1121 – 117656TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini1182 – 121938PLACPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi153 – 1564Poly-Ser

Sequence similaritiesi

Contains 1 disintegrin domain.Curated
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation
Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 5 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
GeneTreeiENSGT00760000118880.
HOGENOMiHOG000004800.
HOVERGENiHBG004315.
InParanoidiQ4VC17.
KOiK08632.
OMAiGCLVDEP.
OrthoDBiEOG091G14M8.
TreeFamiTF313537.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF08686. PLAC. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 5 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4VC17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECALLCLCA LRAAGPGPPW GPAGLGRLAK ALQLCCFCCA SVAVALASDS
60 70 80 90 100
GSSGGSGLND DYVFVVPVEV DSGGSYISHD ILHHRKRRSA HGASNSLHYR
110 120 130 140 150
VSAFGQDLHL ELKPSAILSS HFRVQVLGKD GASETREPEV PQCLYQGFIR
160 170 180 190 200
NDSSSSVAVS TCAGLSGLIR TRDNEFLISP LPQLLAQEHN YSSPAGHHPH
210 220 230 240 250
VLYKRTAEKR VRWYQDYPGS QRTYPGHSPS HTPPASQSQE PEYSHRRWQK
260 270 280 290 300
RHFCGRRKKY APKPPAEDAY LRFDEYGGTG RPRRSAGKSQ NGLNVETLVV
310 320 330 340 350
ADAKMVEKHG KDDVTTYILT VMNMVSSLFK DGTIGSDINI VVVSLILLEE
360 370 380 390 400
EPEGLLINHH ADQSLNSFCQ WQSALVGKNG KRHDHAILLT GFDICSWKNE
410 420 430 440 450
PCDTLGFAPI SGMCSKYRSC TINEDTGLGL AFTIAHESGH NFGMVHDGEG
460 470 480 490 500
NPCRKAEGNI MSPTLTGNNG VFSWSSCSRQ YLKKFLSTPQ AGCLVDEPKQ
510 520 530 540 550
TGQYKYPDKL PGQIYDADMQ CKWQFGAKAK LCSLGVMKDI CKSLWCHRVG
560 570 580 590 600
HRCETKFMPA AEGTACGLSM WCRQGQCVKL GELGPRPIHG QWSAWSKWSE
610 620 630 640 650
CSRTCGGGVK FQERHCSNPK PQYGGKYCPG SSRIYKLCNI NPCPENSLDF
660 670 680 690 700
RAQQCAEYNN KPFRGWLYRW KPYTKVEEED RCKLYCKAEN FEFFFAMSGK
710 720 730 740 750
VKDGTPCSPH RNDVCIDGIC ELVGCDHELG SKAVSDACGV CKGDNSTCKF
760 770 780 790 800
YKGLYLSQHK ANEYYPVVTI PAGARSIEIQ ELQLSSSYLA VRSLSQKYYL
810 820 830 840 850
TGGWSIDWPG DFTFAGTTFE YQRSFNRPER LYAPGPTNET LVFEILTQGK
860 870 880 890 900
NPGIAWKYAL PKVMNVTQPA TKRYHHTWRT VQSDCSVTCG GGYISIKAIC
910 920 930 940 950
LRDQHTQVNS SFCSVRTKPA TEPKICNAFS CPAYWLPGEW SACSKSCAGG
960 970 980 990 1000
QQSRKIRCVQ KKPFQKEEAV LHSLCPVSTP TQVQVCNSHA CPPEWSPSPW
1010 1020 1030 1040 1050
SQCSKTCGRG VRRREVLCKS PAAETLPESL CSSSPRPEAQ EGCVLGRCPK
1060 1070 1080 1090 1100
NNRLQWIASA WSECSATCGL GVRKRELKCV EKTLQGKLIT FPERRCRNIK
1110 1120 1130 1140 1150
KPSLELEEAC NQRTCPVYSM AVASWYSSPW QQCTVTCGGG VQTRSVHCMQ
1160 1170 1180 1190 1200
QGRPSSSCLL HQKPPVLRAC NTNFCPAPEK KDDPSCVDFF SWCHLVPQHG
1210
VCNHKFYGKQ CCRSCTRKS
Length:1,219
Mass (Da):135,244
Last modified:July 27, 2011 - v2
Checksum:i22D0A535E55553A2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961S → P in AAH94674 (PubMed:15489334).Curated
Sequence conflicti189 – 1891H → L in AAH94674 (PubMed:15489334).Curated
Sequence conflicti487 – 49711STPQAGCLVDE → RTPRCIAFLTG in BAC29190 (PubMed:16141072).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108856 Genomic DNA. No translation available.
AC125463 Genomic DNA. No translation available.
BC094674 mRNA. Translation: AAH94674.1.
AK035797 mRNA. Translation: BAC29190.1.
CCDSiCCDS40485.1.
RefSeqiNP_766054.2. NM_172466.2.
UniGeneiMm.167471.

Genome annotation databases

EnsembliENSMUST00000093113; ENSMUSP00000090801; ENSMUSG00000053399.
GeneIDi208936.
KEGGimmu:208936.
UCSCiuc009nnr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108856 Genomic DNA. No translation available.
AC125463 Genomic DNA. No translation available.
BC094674 mRNA. Translation: AAH94674.1.
AK035797 mRNA. Translation: BAC29190.1.
CCDSiCCDS40485.1.
RefSeqiNP_766054.2. NM_172466.2.
UniGeneiMm.167471.

3D structure databases

ProteinModelPortaliQ4VC17.
SMRiQ4VC17. Positions 295-806, 998-1085.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090801.

Protein family/group databases

MEROPSiM12.030.

PTM databases

PhosphoSiteiQ4VC17.

Proteomic databases

PaxDbiQ4VC17.
PRIDEiQ4VC17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093113; ENSMUSP00000090801; ENSMUSG00000053399.
GeneIDi208936.
KEGGimmu:208936.
UCSCiuc009nnr.1. mouse.

Organism-specific databases

CTDi170692.
MGIiMGI:2442600. Adamts18.

Phylogenomic databases

eggNOGiKOG3538. Eukaryota.
ENOG410XPKZ. LUCA.
GeneTreeiENSGT00760000118880.
HOGENOMiHOG000004800.
HOVERGENiHBG004315.
InParanoidiQ4VC17.
KOiK08632.
OMAiGCLVDEP.
OrthoDBiEOG091G14M8.
TreeFamiTF313537.

Miscellaneous databases

PROiQ4VC17.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053399.
GenevisibleiQ4VC17. MM.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR002870. Peptidase_M12B_N.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF08686. PLAC. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 6 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 5 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATS18_MOUSE
AccessioniPrimary (citable) accession number: Q4VC17
Secondary accession number(s): E9QNK0, Q8BZD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.