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Protein

Putative protein MSS51 homolog, mitochondrial

Gene

MSS51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri105 – 14945MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • social behavior Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein MSS51 homolog, mitochondrial
Alternative name(s):
Zinc finger MYND domain-containing protein 17
Gene namesi
Name:MSS51
Synonyms:ZMYND17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21000. MSS51.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134886837.

Polymorphism and mutation databases

BioMutaiMSS51.
DMDMi152143027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Putative protein MSS51 homolog, mitochondrialPRO_0000289109Add
BLAST

Proteomic databases

PaxDbiQ4VC12.
PRIDEiQ4VC12.

Expressioni

Gene expression databases

BgeeiQ4VC12.
CleanExiHS_ZMYND17.
ExpressionAtlasiQ4VC12. baseline and differential.
GenevisibleiQ4VC12. HS.

Organism-specific databases

HPAiHPA038564.

Interactioni

Protein-protein interaction databases

BioGridi125613. 2 interactions.
IntActiQ4VC12. 1 interaction.
STRINGi9606.ENSP00000299432.

Structurei

3D structure databases

ProteinModelPortaliQ4VC12.
SMRiQ4VC12. Positions 105-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri105 – 14945MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFJH. Eukaryota.
ENOG410YYNB. LUCA.
GeneTreeiENSGT00390000014824.
HOGENOMiHOG000155788.
HOVERGENiHBG055520.
InParanoidiQ4VC12.
KOiK17656.
OMAiNKQPVYC.
PhylomeDBiQ4VC12.
TreeFamiTF330829.

Family and domain databases

InterProiIPR002893. Znf_MYND.
[Graphical view]
PfamiPF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4VC12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRSRRRRH KKPPSSVAPI IMAPTTIVTP VPLTPSKPGP SIDTLGFFSL
60 70 80 90 100
DDNVPGLSQL ILQKLNMKSY EEYKLVVDGG TPVSGFGFRC PQEMFQRMED
110 120 130 140 150
TFRFCAHCRA LPSGLSDSKV LRHCKRCRNV YYCGPECQKS DWPAHRRVCQ
160 170 180 190 200
ELRLVAVDRL MEWLLVTGDF VLPSGPWPWP PEAVQDWDSW FSMKGLHLDA
210 220 230 240 250
TLDAVLVSHA VTTLWASVGR PRPDPDVLQG SLKRLLTDVL SRPLTLGLGL
260 270 280 290 300
RALGIDVRRT GGSTVHVVGA SHVETFLTRP GDYDELGYMF PGHLGLRVVM
310 320 330 340 350
VGVDVATGFS QSTSTSPLEP GTIQLSAHRG LYHDFWEEQV ETGQTHHPDL
360 370 380 390 400
VAAFHPGFHS SPDLMEAWLP TLLLLRDYKI PTLITVYSHQ ELVSSLQILV
410 420 430 440 450
ELDTHITAFG SNPFMSLKPE QVYSSPNKQP VYCSAYYIMF LGSSCQLDNR
460
QLEEKVDGGI
Length:460
Mass (Da):51,289
Last modified:May 29, 2007 - v2
Checksum:i045C9C9CAE0FD639
GO
Isoform 2 (identifier: Q4VC12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-221: Missing.
     222-309: RPDPDVLQGS...MVGVDVATGF → MGVPPYQALD...LWTVSWNGFW

Note: No experimental confirmation available.
Show »
Length:239
Mass (Da):26,851
Checksum:iF7B5B5832D780065
GO
Isoform 3 (identifier: Q4VC12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-221: Missing.
     222-309: RPDPDVLQGS...MVGVDVATGF → MGVPPYQALD...LWTVSWNGFW
     310-316: SQSTSTS → SQVEWWC
     317-460: Missing.

Note: No experimental confirmation available.
Show »
Length:95
Mass (Da):10,796
Checksum:i1BA2446A4B9A0FBF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti409 – 4091F → V in AAH94693 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti417 – 4171L → P.
Corresponds to variant rs11591720 [ dbSNP | Ensembl ].
VAR_052993

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 221221Missing in isoform 2 and isoform 3. 2 PublicationsVSP_025898Add
BLAST
Alternative sequencei222 – 30988RPDPD…VATGF → MGVPPYQALDFDVLKKCSRG WKTHFDSVLTVEHSLVGFQT PRFSGTVRGAEMSITVVQSA RSQTGPHTGGFVKSFVLWLW TVSWNGFW in isoform 2 and isoform 3. 2 PublicationsVSP_025899Add
BLAST
Alternative sequencei310 – 3167SQSTSTS → SQVEWWC in isoform 3. 1 PublicationVSP_025900
Alternative sequencei317 – 460144Missing in isoform 3. 1 PublicationVSP_025901Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096884 mRNA. Translation: BAC04883.1.
BX537678 mRNA. Translation: CAD97808.1.
AL353731 Genomic DNA. Translation: CAI52491.1.
BC094693 mRNA. Translation: AAH94693.1.
BC109255 mRNA. Translation: AAI09256.1.
BC109256 mRNA. Translation: AAI09257.1.
CCDSiCCDS31221.1. [Q4VC12-1]
RefSeqiNP_001019764.1. NM_001024593.1. [Q4VC12-1]
UniGeneiHs.631823.

Genome annotation databases

EnsembliENST00000299432; ENSP00000299432; ENSG00000166343. [Q4VC12-1]
ENST00000372912; ENSP00000362003; ENSG00000166343. [Q4VC12-1]
GeneIDi118490.
KEGGihsa:118490.
UCSCiuc001jud.4. human. [Q4VC12-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096884 mRNA. Translation: BAC04883.1.
BX537678 mRNA. Translation: CAD97808.1.
AL353731 Genomic DNA. Translation: CAI52491.1.
BC094693 mRNA. Translation: AAH94693.1.
BC109255 mRNA. Translation: AAI09256.1.
BC109256 mRNA. Translation: AAI09257.1.
CCDSiCCDS31221.1. [Q4VC12-1]
RefSeqiNP_001019764.1. NM_001024593.1. [Q4VC12-1]
UniGeneiHs.631823.

3D structure databases

ProteinModelPortaliQ4VC12.
SMRiQ4VC12. Positions 105-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125613. 2 interactions.
IntActiQ4VC12. 1 interaction.
STRINGi9606.ENSP00000299432.

Polymorphism and mutation databases

BioMutaiMSS51.
DMDMi152143027.

Proteomic databases

PaxDbiQ4VC12.
PRIDEiQ4VC12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299432; ENSP00000299432; ENSG00000166343. [Q4VC12-1]
ENST00000372912; ENSP00000362003; ENSG00000166343. [Q4VC12-1]
GeneIDi118490.
KEGGihsa:118490.
UCSCiuc001jud.4. human. [Q4VC12-1]

Organism-specific databases

CTDi118490.
GeneCardsiMSS51.
H-InvDBHIX0008925.
HGNCiHGNC:21000. MSS51.
HPAiHPA038564.
MIMi614773. gene.
neXtProtiNX_Q4VC12.
PharmGKBiPA134886837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJH. Eukaryota.
ENOG410YYNB. LUCA.
GeneTreeiENSGT00390000014824.
HOGENOMiHOG000155788.
HOVERGENiHBG055520.
InParanoidiQ4VC12.
KOiK17656.
OMAiNKQPVYC.
PhylomeDBiQ4VC12.
TreeFamiTF330829.

Miscellaneous databases

ChiTaRSiMSS51. human.
GenomeRNAii118490.
NextBioi80312.
PROiQ4VC12.
SOURCEiSearch...

Gene expression databases

BgeeiQ4VC12.
CleanExiHS_ZMYND17.
ExpressionAtlasiQ4VC12. baseline and differential.
GenevisibleiQ4VC12. HS.

Family and domain databases

InterProiIPR002893. Znf_MYND.
[Graphical view]
PfamiPF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skeletal muscle.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Fetal brain.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSS51_HUMAN
AccessioniPrimary (citable) accession number: Q4VC12
Secondary accession number(s): A6NGH6
, Q2VP95, Q5F2H5, Q7Z3M9, Q8N8G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 11, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although no clear MSS51 ortholog is encoded in mammalian genomes, the mammalian MSS51/ZMYND17 protein is significantly similar. Considered by a number of resources to be the ortholog of yeast MSS51.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.